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POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu27038 NM_007055 Homo sapiens polymerase (RNA) III (DNA directed) polypeptide A, 155kDa (POLR3A), mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu43993 XM_006717597 PREDICTED: Homo sapiens polymerase (RNA) III (DNA directed) polypeptide A, 155kDa (POLR3A), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu27038C NM_007055 Homo sapiens polymerase (RNA) III (DNA directed) polypeptide A, 155kDa (POLR3A), mRNA. Customized vector On-demand 25 $1699.00
OHu43993C XM_006717597 PREDICTED: Homo sapiens polymerase (RNA) III (DNA directed) polypeptide A, 155kDa (POLR3A), transcript variant X1, mRNA. Customized vector On-demand 25 $1699.00

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Gene Symbol POLR3A
Entrez Gene ID 11128
Full Name polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Synonyms ADDH, HLD7, RPC1, RPC155, hRPC155
General protein information
Preferred Names
DNA-directed RNA polymerase III subunit RPC1
Names
DNA-directed RNA polymerase III subunit RPC1
RNA polymerase III subunit C1
RNA polymerase III subunit C160
RNA polymerase III 155 kDa subunit
RNA polymerase III subunit RPC155-D
DNA-directed RNA polymerase III subunit A
DNA-directed RNA polymerase III largest subunit
NP_008986.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q22-q23

Summary The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011].
Disorder

MIM: 614258

mRNA Protein Product Sequence Price Select
NM_007055, 296011005 NP_008986, 39725938 DNA-directed RNA polymerase III subunit RPC1 ORF Sequence $1500.00
XM_006717597, 578818841 XP_006717660, 578818842 DNA-directed RNA polymerase III subunit RPC1 isoform X1 ORF Sequence $1500.00
KEGG
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa03020RNA polymerase
hsa04623Cytosolic DNA-sensing pathway
hsa_M00181RNA polymerase III, eukaryotes
hsa05169Epstein-Barr virus infection
Reactome
REACT_71Gene Expression
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_1371RNA Polymerase III Transcription
REACT_281RNA Polymerase III Transcription Initiation
REACT_571RNA Polymerase III Transcription Initiation From Type 3 Promoter
REACT_756RNA Polymerase III Chain Elongation
REACT_347RNA Polymerase III Transcription Initiation From Type 1 Promoter
REACT_1036RNA Polymerase III Transcription Initiation From Type 2 Promoter
REACT_63RNA Polymerase III Transcription Termination
REACT_22339RNA Polymerase III Abortive And Retractive Initiation
REACT_21352RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
REACT_118823Cytosolic sensors of pathogen-associated DNA
Homo sapiens (human)POLR3ANP_008986.2
Pan troglodytes (chimpanzee)POLR3AXP_507865.4
Macaca mulatta (Rhesus monkey)POLR3AXP_002805710.1
Canis lupus familiaris (dog)POLR3AXP_536399.2
Bos taurus (cattle)POLR3ANP_001077219.1
Mus musculus (house mouse)Polr3aNP_001074716.1
Rattus norvegicus (Norway rat)Polr3aXP_341389.5
Gallus gallus (chicken)POLR3ANP_001006500.1
Danio rerio (zebrafish)polr3aNP_001263425.1
Drosophila melanogaster (fruit fly)CG17209NP_001096987.2
Caenorhabditis elegansrpc-1NP_501127.2
Arabidopsis thaliana (thale cress)NRPC1NP_200812.2
Xenopus (Silurana) tropicalis (western clawed frog)polr3aNP_001096178.1
Process
IDNameEvidence
GO:0006351transcription, DNA-templatedNAS
GO:0006383transcription from RNA polymerase III promoterTAS
GO:0006385transcription elongation from RNA polymerase III promoterTAS
GO:0006386termination of RNA polymerase III transcriptionTAS
GO:0010467gene expressionTAS
GO:0032481positive regulation of type I interferon productionTAS
GO:0032728positive regulation of interferon-beta productionIMP
GO:0045087innate immune responseIMP
GO:0045087innate immune responseTAS
GO:0051607defense response to virusIEA
Component
IDNameEvidence
GO:0005654nucleoplasmTAS
GO:0005666DNA-directed RNA polymerase III complexIDA
GO:0005829cytosolTAS
GO:0016020membraneIDA
Function
IDNameEvidence
GO:0001056RNA polymerase III activityIBA
GO:0003677DNA bindingIEA
GO:0003682chromatin bindingIEA
GO:0003899DNA-directed RNA polymerase activityNAS
GO:0008270zinc ion bindingIEA
GO:0032549ribonucleoside bindingIEA
GeneCards POLR3A
UniProt O14802
Vega OTTHUMG00000018550
MIM 614258
Ensembl ENSG00000148606
HGNC 30074
HPRD 17879

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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