Sequence in raw or FASTA format:
MAN1B1 mannosidase, alpha, class 1B, member 1 [Homo sapiens (human)]
| Gene Symbol | MAN1B1 |
| Entrez Gene ID | 11253 |
| Full Name | mannosidase, alpha, class 1B, member 1 |
| Synonyms | ERMan1, MANA-ER |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
9 9q34 |
| Summary | |
| Disorder | MIM: 604346 |
| mRNA | NM_016219, 218749882 |
| Protein | NP_057303, 218749883 |
| Product | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase |
| RefSeq Status | VALIDATED |
| hsa04141 | Protein processing in endoplasmic reticulum |
| hsa00510 | N-Glycan biosynthesis |
| hsa01100 | Metabolic pathways |
Reactome
| REACT_23810 | Calnexin/calreticulin cycle |
| REACT_22426 | Asparagine N-linked glycosylation |
| REACT_23878 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| REACT_25091 | ER Quality Control Compartment (ERQC) |
| REACT_17015 | Metabolism of proteins |
| REACT_22161 | Post-translational protein modification |
| Homo sapiens (human) | MAN1B1 | NP_057303.2 |
| Pan troglodytes (chimpanzee) | MAN1B1 | XP_001135997.1 |
| Canis lupus familiaris (dog) | MAN1B1 | XP_537786.2 |
| Mus musculus (house mouse) | Man1b1 | NP_001025154.1 |
| Rattus norvegicus (Norway rat) | Man1b1 | XP_575086.2 |
| Gallus gallus (chicken) | MAN1B1 | XP_415569.2 |
| Danio rerio (zebrafish) | man1b1 | NP_001093449.1 |
| Danio rerio (zebrafish) | LOC562592 | XP_691064.2 |
| Drosophila melanogaster (fruit fly) | CG11874 | NP_651667.1 |
| Caenorhabditis elegans | man(9)-alpha-mannosidase | NP_508877.1 |
| Caenorhabditis elegans | Man(9)-alpha-mannosidase | NP_501577.1 |
| Arabidopsis thaliana (thale cress) | AT1G30000 | NP_564345.1 |
| ID | Name | Evidence |
| GO:0006457 | protein folding | EXP |
| GO:0006487 | protein N-linked glycosylation | NAS |
| GO:0008152 | metabolic process | IEA |
| GO:0009311 | oligosaccharide metabolic process | TAS |
| GO:0018279 | protein N-linked glycosylation via asparagine | TAS |
| GO:0030433 | ER-associated protein catabolic process | IEA |
| GO:0043687 | post-translational protein modification | TAS |
| GO:0044267 | cellular protein metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005783 | endoplasmic reticulum | IEA |
| GO:0005789 | endoplasmic reticulum membrane | IEA |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | TAS |
| GO:0044322 | endoplasmic reticulum quality control compartment | EXP |
| GO:0044322 | endoplasmic reticulum quality control compartment | TAS |
Function
| ID | Name | Evidence |
| GO:0004559 | alpha-mannosidase activity | EXP |
| GO:0004559 | alpha-mannosidase activity | TAS |
| GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | TAS |
| GO:0005509 | calcium ion binding | TAS |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA |
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