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CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000742 Homo sapiens cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001282455 Homo sapiens cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005273397 PREDICTED: Homo sapiens cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006716282 PREDICTED: Homo sapiens cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006716283 PREDICTED: Homo sapiens cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol CHRNA2
Entrez Gene ID 1135
Full Name cholinergic receptor, nicotinic, alpha 2 (neuronal)
Synonyms
General protein information
Preferred Names
neuronal acetylcholine receptor subunit alpha-2
Names
neuronal acetylcholine receptor subunit alpha-2
acetylcholine receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p21

Summary Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009].
Disorder

MIM: 118502

Epilepsy, nocturnal frontal lobe, type 4, 610353 (3)

mRNA Protein Product Sequence Price Select
NM_000742, 157074211 NP_000733, 153792669 neuronal acetylcholine receptor subunit alpha-2 isoform 1 precursor ORF Sequence $550.00
NM_001282455, 540344545 NP_001269384, 540344546 neuronal acetylcholine receptor subunit alpha-2 isoform 2 precursor ORF Sequence $550.00
XM_005273397, 530387558 XP_005273454, 530387559 neuronal acetylcholine receptor subunit alpha-2 isoform X2 ORF Sequence $400.00
XM_006716282, 578815178 XP_006716345, 578815179 neuronal acetylcholine receptor subunit alpha-2 isoform X3 ORF Sequence $550.00
XM_006716283, 578815180 XP_006716346, 578815181 neuronal acetylcholine receptor subunit alpha-2 isoform X4 ORF Sequence $550.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
Reactome
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_13477Transmission across Chemical Synapses
REACT_15461Acetylcholine Binding And Downstream Events
REACT_13685Neuronal System
REACT_22149Postsynaptic nicotinic acetylcholine receptors
REACT_22303Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
REACT_22126Activation of Nicotinic Acetylcholine Receptors
REACT_22336Presynaptic nicotinic acetylcholine receptors
REACT_22352Highly calcium permeable nicotinic acetylcholine receptors
Homo sapiens (human)CHRNA2NP_000733.2
Pan troglodytes (chimpanzee)CHRNA2NP_001029107.1
Macaca mulatta (Rhesus monkey)CHRNA2XP_001109335.1
Canis lupus familiaris (dog)CHRNA2XP_005635946.1
Bos taurus (cattle)CHRNA2NP_001179639.1
Mus musculus (house mouse)Chrna2NP_659052.1
Rattus norvegicus (Norway rat)Chrna2NP_596911.1
Gallus gallus (chicken)CHRNA2NP_990146.1
Drosophila melanogaster (fruit fly)nAcRalpha-96AbNP_733001.1
Xenopus (Silurana) tropicalis (western clawed frog)chrna2XP_002941292.2
Process
IDNameEvidence
GO:0006811ion transportNAS
GO:0006812cation transportIDA
GO:0006812cation transportIEA
GO:0007165signal transductionIDA
GO:0007268synaptic transmissionTAS
GO:0034220ion transmembrane transportIEA
GO:0051291protein heterooligomerizationIEA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005892acetylcholine-gated channel complexIDA
GO:0016021integral component of membraneNAS
GO:0030054cell junctionIEA
GO:0045211postsynaptic membraneIEA
Function
IDNameEvidence
GO:0004889acetylcholine-activated cation-selective channel activityIDA
GO:0008144drug bindingIEA
GO:0015464acetylcholine receptor activityIDA
GO:0042166acetylcholine bindingIEA
GeneCards CHRNA2
UniProt Q15822
Vega OTTHUMG00000102083
MIM 118502
Ensembl ENSG00000120903
HGNC 1956
HPRD 00332

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CHRNA2 gene?

The CHRNA2 gene provides instructions for making one part (subunit) of a larger protein called a neuronal nicotinic acetylcholine receptor (nAChR). Each nAChR protein is made up of a combination of five subunits, usually two alpha (α) and three beta (β) subunits. Many different combinations are possible, and the characteristics of each nAChR protein depend on which subunits it contains. The CHRNA2 gene is responsible for producing a subunit known as α2. Little is known about the specific function of nAChR proteins made with this subunit.

In the brain, nAChR proteins are widely distributed and play an important role in chemical signaling between nerve cells (neurons). The proteins act as channels, allowing charged atoms (ions) including calcium, sodium, and potassium to cross the cell membrane. These channels open when attached to a brain chemical (neurotransmitter) called acetylcholine. The channels also open in response to nicotine, the addictive substance in tobacco.

Communication between neurons depends on neurotransmitters, which are released from one neuron and taken up by neighboring neurons. The release and uptake of these chemicals are tightly regulated to ensure that signals are passed efficiently and accurately between neurons. Researchers believe that nAChR channels play an important role in controlling the normal release and uptake of neurotransmitters.

A wide range of brain functions depend on nAChR channels, including sleep and arousal, fatigue, anxiety, attention, pain perception, and memory. The channels are also active before birth, which suggests that they are involved in early brain development. At least one drug that targets nAChR channels in the brain has been developed to help people quit smoking; other medications targeting these channels are under study for the treatment of schizophrenia, Alzheimer disease, and pain.

Interactant

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