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CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000742 Homo sapiens cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol CHRNA2
Entrez Gene ID 1135
Full Name cholinergic receptor, nicotinic, alpha 2 (neuronal)
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009].

MIM: 118502

Epilepsy, nocturnal frontal lobe, type 4, 610353 (3)

mRNA Protein Product Sequence Price Select
NM_000742, 157074211 NP_000733, 153792669 neuronal acetylcholine receptor subunit alpha-2 precursor ORF Sequence $550.00
hsa04080Neuroactive ligand-receptor interaction
REACT_15461Acetylcholine Binding And Downstream Events
REACT_13477Transmission across Chemical Synapses
REACT_13685Neuronal System
REACT_22126Activation of Nicotinic Acetylcholine Receptors
REACT_22352Highly calcium permeable nicotinic acetylcholine receptors
REACT_22303Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_22336Presynaptic nicotinic acetylcholine receptors
REACT_22149Postsynaptic nicotinic acetylcholine receptors
Homo sapiens (human)CHRNA2NP_000733.2
Pan troglodytes (chimpanzee)CHRNA2NP_001029107.1
Macaca mulatta (Rhesus monkey)CHRNA2XP_001109335.1
Canis lupus familiaris (dog)CHRNA2XP_543227.2
Bos taurus (cattle)CHRNA2NP_001179639.1
Mus musculus (house mouse)Chrna2NP_659052.1
Rattus norvegicus (Norway rat)Chrna2NP_596911.1
Gallus gallus (chicken)CHRNA2NP_990146.1
Danio rerio (zebrafish)chrna2bXP_697298.3
Danio rerio (zebrafish)chrna2aNP_001035417.1
Drosophila melanogaster (fruit fly)nAcRalpha-96AbNP_524482.1
GeneCards CHRNA2
UniProt Q15822
MIM 118502
Ensembl ENSG00000120903
HGNC 1956
HPRD 00332

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
neuronal acetylcholine receptor subunit alpha-2
neuronal acetylcholine receptor subunit alpha-2
acetylcholine receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)


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