Sequence in raw or FASTA format:
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) [
Homo sapiens (human)]
Gene Symbol MAL2
Entrez Gene ID
Full Name mal, T-cell differentiation protein 2 (gene/pseudogene)
General protein information
MAL2 proteolipid protein
MAL proteolipid protein 2
Gene Type protein-coding
Homo sapiens (human)
Chromosome:8 Map Location:8q23
Summary This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008].
Related articles in PubMed Protein phosphatase 1α interacting proteins in the human brain. Esteves SL, et al. OMICS, 2012 Jan-Feb. PMID 22321011. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832. Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG. Bello-Morales R, et al. PLoS One, 2011 May 9. PMID 21573057. MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome. Byrne JA, et al. BMC Cancer, 2010 Sep 17. PMID 20846453. Characterization of the MAL2-positive compartment in oligodendrocytes. Bello-Morales R, et al. Exp Cell Res, 2009 Nov 15. PMID 19683524. See all (21) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Results prove for the first time the interaction of PLP and MAL2 in oligodendrocytic cells, supporting the transcytotic model of PLP transport previously suggested.
Title: Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.
MAL2 overexpression was highest in serous carcinomas relative to other histological subtypes of ovarian cancer.
Title: MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome.
after differentiation, murine oligodendrocyte precursor and human oligodendroglioma derived cell lines up-regulate the expression of MAL2 and accumulate it in an intracellular compartment, exhibiting a peri-centrosomal localization.
Title: Characterization of the MAL2-positive compartment in oligodendrocytes.
a role for MAL2 in regulating tumor-associated protein mucin expression and/or localisation
Title: Mucin 1 (MUC1) is a novel partner for MAL2 in breast carcinoma cells.
The MAL2 gene was shown to effectively separate these two tumor(chromophobe renal cell carcinoma (RCC) and benign oncocytoma) groups by quantitative reverse transcription-PCR using fresh tissue samples, with similar trends seen on formalin-fixed tissues.
Title: Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes.
The results indicate that MAL2 protein genes are not ubiquitously expressed in leukemic bone marrow in children, and that RNA sample parameters may influence measures of gene expression more than commonly appreciated.
Title: Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations.
MAL2 protein mRNA species were detected in the thyroid and immunohistochemical analysis of thyroid follicles indicated that MAL2 distributed to the apical membrane
Title: Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells.
Data show that MAL2 is essential for transcytosis in HepG2 cells.
Title: MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells.
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