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CATSPER1 cation channel, sperm associated 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_053054 Homo sapiens cation channel, sperm associated 1 (CATSPER1), mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005273755 PREDICTED: Homo sapiens cation channel, sperm associated 1 (CATSPER1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol CATSPER1
Entrez Gene ID 117144
Full Name cation channel, sperm associated 1
Synonyms CATSPER, SPGF7
General protein information
Preferred Names
cation channel sperm-associated protein 1
Names
cation channel sperm-associated protein 1
hCatSper
sperm ion channel
sperm-associated cation channel 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q12.1

Summary Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008].
Disorder

MIM: 606389

Male infertility, nonsyndromic, autosomal recessive, 612997 (3)

mRNA Protein Product Sequence Price Select
NM_053054, 221316608 NP_444282, 221316609 cation channel sperm-associated protein 1 ORF Sequence $750.00
XM_005273755, 530396282 XP_005273812, 530396283 cation channel sperm-associated protein 1 isoform X1 ORF Sequence $700.00
Reactome
REACT_163914Fertilization
REACT_163875Sperm Motility And Taxes
REACT_163848Reproduction
Homo sapiens (human)CATSPER1NP_444282.3
Pan troglodytes (chimpanzee)CATSPER1XP_003313190.1
Macaca mulatta (Rhesus monkey)CATSPER1XP_001118063.1
Canis lupus familiaris (dog)CATSPER1XP_005631803.1
Bos taurus (cattle)CATSPER1XP_005227286.1
Mus musculus (house mouse)Catsper1NP_647462.1
Rattus norvegicus (Norway rat)Catsper1XP_001070492.2
Process
IDNameEvidence
GO:0001539cilium or flagellum-dependent cell motilityIEA
GO:0007275multicellular organismal developmentIEA
GO:0007283spermatogenesisIEA
GO:0007338single fertilizationTAS
GO:0007342fusion of sperm to egg plasma membraneIEA
GO:0030154cell differentiationIEA
GO:0030317sperm motilityIBA
GO:0032504multicellular organism reproductionTAS
GO:0034765regulation of ion transmembrane transportIEA
GO:0035036sperm-egg recognitionTAS
GO:0051924regulation of calcium ion transportIEA
GO:0070509calcium ion importIBA
GO:0086010membrane depolarization during action potentialIBA
Component
IDNameEvidence
GO:0005886plasma membraneIBA
GO:0005886plasma membraneTAS
GO:0005929ciliumIEA
GO:0036128CatSper complexISS
Function
IDNameEvidence
GO:0005227calcium activated cation channel activityIEA
GO:0005245voltage-gated calcium channel activityIBA
GO:0005515protein bindingIPI
GeneCards CATSPER1
UniProt Q8NEC5
Vega OTTHUMG00000166668
MIM 606389
Ensembl ENSG00000175294
HGNC 17116
HPRD 09396

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CATSPER1 gene?

The CATSPER1 gene provides instructions for producing a protein that is found in the tail (flagellum) of sperm cells. The CATSPER1 protein plays a role in sperm cell movement (motility) and is required for sperm cells to push through the outside membrane of the egg cell during fertilization. The CATSPER1 protein is embedded in the membrane of sperm cells and is necessary for positively charged calcium atoms (calcium cations) to enter the cell. Calcium cations are required for a type of sperm motility called hyperactivation. Hyperactivation is characterized by vigorous movements of the sperm tail, which are necessary for the sperm to push through the membrane of the egg cell during fertilization.

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