Atp6v1b2 ATPase, H transporting, lysosomal V1 subunit B2 [Rattus norvegicus (Norway rat)]
| Gene Symbol | Atp6v1b2 |
| Entrez Gene ID | 117596 |
| Full Name | ATPase, H transporting, lysosomal V1 subunit B2 |
| Synonyms | Atp6b1b2, Atp6b2, Vatb |
| Gene Type | protein-coding |
| Organism | Rattus norvegicus (Norway rat) |
| Genome |
16 16p14 |
| Summary | subunit of vacuolar H(+)-ATPase [RGD]. |
| Disorder | MIM: |
| mRNA | NM_057213, 55742825 |
| Protein | NP_476561, 17105370 |
| Product | V-type proton ATPase subunit B, brain isoform |
| RefSeq Status | PROVISIONAL |
| rno05323 | Rheumatoid arthritis |
| rno01100 | Metabolic pathways |
| rno00190 | Oxidative phosphorylation |
| rno04145 | Phagosome |
| rno04966 | Collecting duct acid secretion |
Reactome
| 1235567 | Insulin receptor recycling |
| 1235564 | Signaling by Insulin receptor |
| Homo sapiens (human) | ATP6V1B2 | NP_001684.2 |
| Pan troglodytes (chimpanzee) | ATP6V1B2 | XP_519638.2 |
| Canis lupus familiaris (dog) | ATP6V1B2 | XP_543263.2 |
| Bos taurus (cattle) | ATP6V1B2 | NP_788844.2 |
| Mus musculus (house mouse) | Atp6v1b2 | NP_031535.2 |
| Rattus norvegicus (Norway rat) | Atp6v1b2 | NP_476561.1 |
| Gallus gallus (chicken) | ATP6V1B2 | XP_424534.2 |
| Danio rerio (zebrafish) | LOC100332756 | XP_002663572.1 |
| Danio rerio (zebrafish) | atp6v1b2 | NP_878299.1 |
| Drosophila melanogaster (fruit fly) | Vha55 | NP_001163597.1 |
| Caenorhabditis elegans | vha-12 | NP_508711.1 |
| Caenorhabditis elegans | tag-300 | NP_491518.1 |
| Arabidopsis thaliana (thale cress) | AT1G76030 | NP_177729.1 |
| Arabidopsis thaliana (thale cress) | AT1G20260 | NP_173451.5 |
| ID | Name | Evidence |
| GO:0006811 | ion transport | IEA |
| GO:0007035 | vacuolar acidification | TAS |
| GO:0015991 | ATP hydrolysis coupled proton transport | IEA |
| GO:0015992 | proton transport | IEA |
| GO:0030641 | regulation of cellular pH | TAS |
| GO:0033572 | transferrin transport | ISO |
| GO:0046034 | ATP metabolic process | IEA |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | ISO |
| GO:0005794 | Golgi apparatus | IEA |
| GO:0005794 | Golgi apparatus | ISO |
| GO:0005829 | cytosol | ISO |
| GO:0005829 | cytosol | ISS |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | ISS |
| GO:0005902 | microvillus | ISO |
| GO:0016021 | integral to membrane | IDA |
| GO:0033180 | proton-transporting V-type ATPase, V1 domain | IEA |
| GO:0042470 | melanosome | IEA |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
Function
| ID | Name | Evidence |
| GO:0005524 | ATP binding | IEA |
| GO:0016787 | hydrolase activity | IEA |
| GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | IEA |
| GO:0046933 | hydrogen ion transporting ATP synthase activity, rotational mechanism | IEA |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | IEA |
| GeneCards | Atp6v1b2 |
| UniProt | P62815 |
| RGD | 620284 |
| Ensembl | ENSRNOG00000011891 |
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