Apc adenomatosis polyposis coli [Mus musculus (house mouse)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	Apc
Entrez Gene ID	11789
Full Name	adenomatosis polyposis coli
Synonyms	AI047805, AU020952, AW124434, CC1, Min, mAPC
Gene Type	protein-coding
Organism	Mus musculus (house mouse)
Genome	Chromosome:18 Map Location:18 B1\|18 15.0 cM
Summary
Disorder	MIM:

mRNA	NM_007462, 158966685
Protein	NP_031488, 110225370
Product	adenomatous polyposis coli protein
RefSeq Status	VALIDATED

KEGG

mmu05217	Basal cell carcinoma
mmu05210	Colorectal cancer
mmu04310	Wnt signaling pathway
mmu05200	Pathways in cancer
mmu04810	Regulation of actin cytoskeleton
mmu05213	Endometrial cancer

WikiPathways

WP339	ESC Pluripotency Pathways
WP523	Regulation of Actin Cytoskeleton
WP723	Wnt Signaling Pathway and Pluripotency
WP1763	PluriNetWork
WP403	Wnt Signaling Pathway
WP475	Irinotecan Pathway
WP539	Wnt Signaling Pathway NetPath

Reactome

1210672	Degradation of beta-catenin by the destruction complex
1210711	Apoptotic cleavage of cellular proteins
1210712	Apoptotic execution phase
1210115	Apoptosis
1210673	Signaling by Wnt
1210674	Beta-catenin phosphorylation cascade

Homo sapiens (human)	APC	NP_000029.2
Pan troglodytes (chimpanzee)	APC	XP_001143366.1
Canis lupus familiaris (dog)	APC	XP_536285.2
Bos taurus (cattle)	APC	XP_001787655.1
Mus musculus (house mouse)	Apc	NP_031488.2
Rattus norvegicus (Norway rat)	Apc	NP_036631.1
Gallus gallus (chicken)	APC	XP_001233411.1
Danio rerio (zebrafish)	apc	NP_001137312.1

Process

ID	Name	Evidence
GO:0000281	cytokinesis after mitosis	IMP
GO:0000281	cytokinesis after mitosis	ISO
GO:0001822	kidney development	IMP
GO:0001942	hair follicle development	IMP
GO:0006461	protein complex assembly	ISO
GO:0006974	response to DNA damage stimulus	ISO
GO:0007026	negative regulation of microtubule depolymerization	IMP
GO:0007026	negative regulation of microtubule depolymerization	ISO
GO:0007050	cell cycle arrest	ISO
GO:0007091	mitotic metaphase/anaphase transition	IGI
GO:0007091	mitotic metaphase/anaphase transition	IMP
GO:0007094	mitotic cell cycle spindle assembly checkpoint	ISO
GO:0007163	establishment or maintenance of cell polarity	ISO
GO:0007389	pattern specification process	IMP
GO:0007409	axonogenesis	IGI
GO:0007409	axonogenesis	IMP
GO:0008285	negative regulation of cell proliferation	IGI
GO:0008285	negative regulation of cell proliferation	IMP
GO:0008285	negative regulation of cell proliferation	ISO
GO:0009798	axis specification	IMP
GO:0009952	anterior/posterior pattern formation	IMP
GO:0009953	dorsal/ventral pattern formation	IMP
GO:0009954	proximal/distal pattern formation	IMP
GO:0016055	Wnt receptor signaling pathway	IDA
GO:0016055	Wnt receptor signaling pathway	IMP
GO:0016477	cell migration	IMP
GO:0016477	cell migration	ISO
GO:0019827	stem cell maintenance	IMP
GO:0030178	negative regulation of Wnt receptor signaling pathway	IGI
GO:0030178	negative regulation of Wnt receptor signaling pathway	IMP
GO:0030334	regulation of cell migration	IGI
GO:0030334	regulation of cell migration	IMP
GO:0030335	positive regulation of cell migration	IMP
GO:0030335	positive regulation of cell migration	ISO
GO:0030856	regulation of epithelial cell differentiation	IMP
GO:0030858	positive regulation of epithelial cell differentiation	IGI
GO:0031116	positive regulation of microtubule polymerization	IMP
GO:0031122	cytoplasmic microtubule organization	IGI
GO:0031175	neuron projection development	ISO
GO:0031274	positive regulation of pseudopodium assembly	ISO
GO:0033077	T cell differentiation in thymus	IMP
GO:0035019	somatic stem cell maintenance	IGI
GO:0035019	somatic stem cell maintenance	IMP
GO:0042483	negative regulation of odontogenesis	IMP
GO:0042981	regulation of apoptosis	IGI
GO:0043065	positive regulation of apoptosis	IMP
GO:0043065	positive regulation of apoptosis	ISO
GO:0043066	negative regulation of apoptosis	IMP
GO:0043409	negative regulation of MAPKKK cascade	IGI
GO:0043409	negative regulation of MAPKKK cascade	IMP
GO:0043588	skin development	IMP
GO:0045595	regulation of cell differentiation	IGI
GO:0045597	positive regulation of cell differentiation	IMP
GO:0045667	regulation of osteoblast differentiation	IMP
GO:0045670	regulation of osteoclast differentiation	IMP
GO:0045732	positive regulation of protein catabolic process	IMP
GO:0045732	positive regulation of protein catabolic process	ISO
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	ISO
GO:0045785	positive regulation of cell adhesion	IMP
GO:0046716	muscle cell homeostasis	IGI
GO:0048538	thymus development	IMP
GO:0050680	negative regulation of epithelial cell proliferation	IGI
GO:0050680	negative regulation of epithelial cell proliferation	IMP
GO:0051171	regulation of nitrogen compound metabolic process	IMP
GO:0051276	chromosome organization	IGI
GO:0051276	chromosome organization	IMP
GO:0051726	regulation of cell cycle	IMP
GO:0051781	positive regulation of cell division	IMP
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	IMP
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	ISO
GO:0060041	retina development in camera-type eye	IMP
GO:0060070	canonical Wnt receptor signaling pathway	IMP
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	IMP
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	ISO

Component

ID	Name	Evidence
GO:0000776	kinetochore	ISO
GO:0005634	nucleus	IDA
GO:0005634	nucleus	ISO
GO:0005737	cytoplasm	IDA
GO:0005737	cytoplasm	ISO
GO:0005813	centrosome	ISO
GO:0005829	cytosol	ISO
GO:0005856	cytoskeleton	IEA
GO:0005874	microtubule	ISO
GO:0005881	cytoplasmic microtubule	IDA
GO:0005923	tight junction	ISO
GO:0016328	lateral plasma membrane	ISO
GO:0030027	lamellipodium	ISO
GO:0030054	cell junction	IEA
GO:0030426	growth cone	IDA
GO:0030426	growth cone	ISO
GO:0030877	beta-catenin destruction complex	ISO
GO:0031253	cell projection membrane	IDA
GO:0032587	ruffle membrane	ISO
GO:0033267	axon part	IDA
GO:0034742	APC-Axin-1-beta-catenin complex	ISO
GO:0034747	Axin-APC-beta-catenin-GSK3B complex	ISO
GO:0034750	Scrib-APC-beta-catenin complex	IDA
GO:0035371	microtubule plus end	IDA
GO:0042995	cell projection	IDA
GO:0043005	neuron projection	ISO
GO:0043025	neuronal cell body	ISO
GO:0044295	axonal growth cone	IDA
GO:0045202	synapse	ISO

Function

ID	Name	Evidence
GO:0005488	binding	IEA
GO:0005515	protein binding	IPI
GO:0008013	beta-catenin binding	IDA
GO:0008013	beta-catenin binding	IPI
GO:0008013	beta-catenin binding	ISO
GO:0008017	microtubule binding	ISO
GO:0019887	protein kinase regulator activity	ISO
GO:0019901	protein kinase binding	ISO
GO:0045295	gamma-catenin binding	ISO
GO:0051010	microtubule plus-end binding	IDA
GO:0051010	microtubule plus-end binding	ISO

GeneCards	Apc
UniProt	B2RUG9, Q8BNP7
MGI	88039
Ensembl	ENSMUSG00000005871

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RefSeq Accession	Definition	Sequence	Price	Select
NM_007462	Mus musculus adenomatosis polyposis coli (Apc), mRNA.	Full Length	Quote
NM_007462	Mus musculus adenomatosis polyposis coli (Apc), mRNA.	ORF Sequence	Quote