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Sequence in raw or FASTA format:

Database:

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Btk Bruton agammaglobulinemia tyrosine kinase [Mus musculus (house mouse)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_013482 Mus musculus Bruton agammaglobulinemia tyrosine kinase (Btk), mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006528483 PREDICTED: Mus musculus Bruton agammaglobulinemia tyrosine kinase (Btk), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006528484 PREDICTED: Mus musculus Bruton agammaglobulinemia tyrosine kinase (Btk), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006528485 PREDICTED: Mus musculus Bruton agammaglobulinemia tyrosine kinase (Btk), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

Related Services

Gene Symbol Btk
Entrez Gene ID 12229
Full Name Bruton agammaglobulinemia tyrosine kinase
Synonyms AI528679, xid
General protein information
Preferred Names
tyrosine-protein kinase BTK
Names
tyrosine-protein kinase BTK
ATK
BPK
kinase EMB
bruton tyrosine kinase
B-cell progenitor kinase
Bruton's tyrosine kinase
X-linked immune deficiency
agammaglobulinemia tyrosine kinase
agammaglobulinaemia tyrosine kinase
Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB)
NP_038510.2
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

X

X E3|X 56.18 cM

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_013482, 161016838 NP_038510, 161016839 tyrosine-protein kinase BTK ORF Sequence $700.00
XM_006528483, 569011231 XP_006528546, 569011232 tyrosine-protein kinase BTK isoform X1 ORF Sequence $700.00
XM_006528484, 569011233 XP_006528547, 569011234 tyrosine-protein kinase BTK isoform X2 ORF Sequence $700.00
XM_006528485, 569011235 XP_006528548, 569011236 tyrosine-protein kinase BTK isoform X3 ORF Sequence $700.00
KEGG
mmu04664Fc epsilon RI signaling pathway
mmu04662B cell receptor signaling pathway
mmu05340Primary immunodeficiency
mmu04380Osteoclast differentiation
mmu04064NF-kappa B signaling pathway
mmu04611Platelet activation
WikiPathways
WP151IL-5 Signaling Pathway
WP387IL-6 signaling Pathway
WP274B Cell Receptor Signaling Pathway
WP407Kit Receptor Signaling Pathway
Reactome
5604809FCERI mediated Ca+2 mobilization
5604802Innate Immune System
5604807Signaling by the B Cell Receptor (BCR)
5604806Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
5604803Immune System
5604808Adaptive Immune System
5604801DAP12 interactions
5604800DAP12 signaling
5604810Fc epsilon receptor (FCERI) signaling
Homo sapiens (human)BTKNP_001274273.1
Pan troglodytes (chimpanzee)BTKXP_001139132.2
Macaca mulatta (Rhesus monkey)BTKXP_002806376.1
Canis lupus familiaris (dog)BTKXP_549139.2
Bos taurus (cattle)BTKNP_001029761.1
Mus musculus (house mouse)BtkNP_038510.2
Rattus norvegicus (Norway rat)BtkNP_001007799.1
Gallus gallus (chicken)BTKNP_989564.2
Danio rerio (zebrafish)btkXP_697087.4
Xenopus (Silurana) tropicalis (western clawed frog)btkNP_001123732.1
Process
IDNameEvidence
GO:0002376immune system processIEA
GO:0002553histamine secretion by mast cellISO
GO:0006351transcription, DNA-templatedIEA
GO:0006355regulation of transcription, DNA-templatedIEA
GO:0006468protein phosphorylationIDA
GO:0006915apoptotic processIEA
GO:0007249I-kappaB kinase/NF-kappaB signalingIMP
GO:0010033response to organic substanceISO
GO:0016310phosphorylationIEA
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0018108peptidyl-tyrosine phosphorylationISO
GO:0034614cellular response to reactive oxygen speciesISO
GO:0035556intracellular signal transductionIEA
GO:0045087innate immune responseIEA
GO:0046777protein autophosphorylationISO
GO:0048469cell maturationIMP
GO:0071226cellular response to molecule of fungal originISO
Component
IDNameEvidence
GO:0005622intracellularIMP
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolISO
GO:0005886plasma membraneISO
GO:0016020membraneIEA
GO:0031410cytoplasmic vesicleIDA
GO:0042629mast cell granuleISO
GO:0043231intracellular membrane-bounded organelleISO
GO:0045121membrane raftISO
GO:0048471perinuclear region of cytoplasmISO
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0004672protein kinase activityIEA
GO:0004713protein tyrosine kinase activityIDA
GO:0004713protein tyrosine kinase activityISO
GO:0004715non-membrane spanning protein tyrosine kinase activityIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0005547phosphatidylinositol-3,4,5-trisphosphate bindingISO
GO:0008289lipid bindingIEA
GO:0016301kinase activityIEA
GO:0016740transferase activityIEA
GO:0016772transferase activity, transferring phosphorus-containing groupsIEA
GO:0042802identical protein bindingISO
GO:0046872metal ion bindingIEA
GeneCards Btk
UniProt P35991
MGI 88216
Vega OTTMUSG00000019307
Ensembl ENSMUSG00000031264

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

What is the normal function of the BTK gene?

The BTK gene provides instructions for making a protein called Bruton tyrosine kinase (BTK), which is essential for the development and maturation of B cells. B cells are specialized white blood cells that help protect the body against infection. These cells can mature into cells that produce special proteins called antibodies or immunoglobulins. Antibodies attach to specific foreign particles and germs, marking them for destruction. The BTK protein transmits important chemical signals that instruct B cells to mature and produce antibodies.

Interactant

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