Btk Bruton agammaglobulinemia tyrosine kinase [Mus musculus (house mouse)]
| Gene Symbol | Btk |
| Entrez Gene ID | 12229 |
| Full Name | Bruton agammaglobulinemia tyrosine kinase |
| Synonyms | AI528679, xid |
| Gene Type | protein-coding |
| Organism | Mus musculus (house mouse) |
| Genome |
X X E3|X 51.0 cM |
| Summary | |
| Disorder | MIM: |
| mRNA | NM_013482, 161016838 |
| Protein | NP_038510, 161016839 |
| Product | tyrosine-protein kinase BTK |
| RefSeq Status | VALIDATED |
| mmu04380 | Osteoclast differentiation |
| mmu04664 | Fc epsilon RI signaling pathway |
| mmu05340 | Primary immunodeficiency |
| mmu04662 | B cell receptor signaling pathway |
WikiPathways
| WP151 | IL-5 Signaling Pathway |
| WP387 | IL-6 signaling Pathway |
| WP274 | B Cell Receptor Signaling Pathway |
| WP407 | Kit Receptor Signaling Pathway |
| Homo sapiens (human) | BTK | NP_000052.1 |
| Pan troglodytes (chimpanzee) | BTK | XP_001138546.1 |
| Canis lupus familiaris (dog) | BTK | XP_861831.1 |
| Bos taurus (cattle) | BTK | NP_001029761.1 |
| Mus musculus (house mouse) | Btk | NP_038510.1 |
| Rattus norvegicus (Norway rat) | Btk | NP_001007799.1 |
| Gallus gallus (chicken) | BTK | NP_989564.2 |
| Danio rerio (zebrafish) | btk | XP_697087.4 |
| ID | Name | Evidence |
| GO:0000302 | response to reactive oxygen species | ISO |
| GO:0002553 | histamine secretion by mast cell | ISO |
| GO:0006468 | protein phosphorylation | IDA |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | IMP |
| GO:0009607 | response to biotic stimulus | ISO |
| GO:0010033 | response to organic substance | ISO |
| GO:0016310 | phosphorylation | IEA |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IDA |
| GO:0035556 | intracellular signal transduction | IEA |
| GO:0046777 | protein autophosphorylation | ISO |
| GO:0048469 | cell maturation | IMP |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IDA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005829 | cytosol | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0016020 | membrane | IEA |
| GO:0031410 | cytoplasmic vesicle | IDA |
| GO:0045121 | membrane raft | ISO |
| GO:0048471 | perinuclear region of cytoplasm | ISO |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004672 | protein kinase activity | IEA |
| GO:0004713 | protein tyrosine kinase activity | IDA |
| GO:0004713 | protein tyrosine kinase activity | ISO |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | ISO |
| GO:0016301 | kinase activity | IEA |
| GO:0016740 | transferase activity | IEA |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | IEA |
| GO:0042802 | identical protein binding | ISO |
| GO:0046872 | metal ion binding | IEA |
| GeneCards | Btk |
| UniProt | A2BDV9, P35991 |
| MGI | 88216 |
| Ensembl | ENSMUSG00000031264 |
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