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COL9A2 collagen, type IX, alpha 2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001852 Homo sapiens collagen, type IX, alpha 2 (COL9A2), mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005270480 PREDICTED: Homo sapiens collagen, type IX, alpha 2 (COL9A2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006710365 PREDICTED: Homo sapiens collagen, type IX, alpha 2 (COL9A2), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol COL9A2
Entrez Gene ID 1298
Full Name collagen, type IX, alpha 2
Synonyms DJ39G22.4, EDM2, MED, STL5
General protein information
Preferred Names
collagen alpha-2(IX) chain
collagen alpha-2(IX) chain
alpha 2 type IX collagen
collagen IX, alpha-2 polypeptide
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. This chain is unusual in that, unlike the other two type IX alpha chains, it contains a covalently attached glycosaminoglycan side chain. Mutations in this gene are associated with multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008].

MIM: 120260

Epiphyseal dysplasia, multiple, 2, 600204 (3); {Intervertebral

mRNA Protein Product Sequence Price Select
NM_001852, 31083125 NP_001843, 11386161 collagen alpha-2(IX) chain precursor ORF Sequence $700.00
XM_005270480, 530361822 XP_005270537, 530361823 collagen alpha-2(IX) chain isoform X1 ORF Sequence $700.00
XM_006710365, 578798413 XP_006710428, 578798414 collagen alpha-2(IX) chain isoform X2 ORF Sequence $700.00
hsa04974Protein digestion and absorption
REACT_18266Axon guidance
REACT_18334NCAM signaling for neurite out-growth
REACT_18312NCAM1 interactions
REACT_13552Integrin cell surface interactions
REACT_16888Signaling by PDGF
REACT_111102Signal Transduction
REACT_111045Developmental Biology
REACT_118572Degradation of the extracellular matrix
REACT_118779Extracellular matrix organization
REACT_120729Collagen formation
REACT_121139Collagen biosynthesis and modifying enzymes
REACT_163906ECM proteoglycans
REACT_150401Collagen degradation
Homo sapiens (human)COL9A2NP_001843.1
Pan troglodytes (chimpanzee)COL9A2XP_003949434.1
Macaca mulatta (Rhesus monkey)COL9A2XP_001082953.2
Canis lupus familiaris (dog)COL9A2NP_001184099.1
Bos taurus (cattle)COL9A2XP_002686588.2
Mus musculus (house mouse)Col9a2NP_031767.2
Rattus norvegicus (Norway rat)Col9a2NP_001102145.1
Gallus gallus (chicken)COL9A2NP_001258917.1
Danio rerio (zebrafish)col9a2NP_997744.1
Xenopus (Silurana) tropicalis (western clawed frog)col9a2NP_001090661.1
GO:0001501skeletal system developmentTAS
GO:0007411axon guidanceTAS
GO:0022617extracellular matrix disassemblyTAS
GO:0030198extracellular matrix organizationTAS
GO:0030574collagen catabolic processTAS
GO:0005576extracellular regionTAS
GO:0005594collagen type IX trimerIDA
GO:0005788endoplasmic reticulum lumenTAS
GO:0030020extracellular matrix structural constituent conferring tensile strengthIC
GeneCards COL9A2
UniProt D3DPU8, Q14055
Vega OTTHUMG00000005761
MIM 120260
Ensembl ENSG00000049089
HGNC 2218
HPRD 00373

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the COL9A2 gene?

The COL9A2 gene provides instructions for making part of a large molecule called type IX collagen. Collagens are a family of proteins that strengthen and support connective tissues, such as skin, bone, cartilage, tendons, and ligaments. In particular, type IX collagen is an important component of cartilage, which is a tough, flexible tissue that makes up much of the skeleton during early development. Most cartilage is later converted to bone, except for the cartilage that continues to cover and protect the ends of bones and is present in the nose and external ears.

Type IX collagen is made up of three proteins that are produced from three distinct genes: one α1(IX) chain, which is produced from the COL9A1 gene, one α2(IX) chain, which is produced from the COL9A2 gene, and one α3(IX) chain, which is produced from the COL9A3 gene. Type IX collagen is more flexible than other types of collagen molecules and is closely associated with type II collagen. Researchers believe that the flexible nature of type IX collagen allows it to act as a bridge that connects type II collagen with other cartilage components. Studies have shown that type IX collagen also interacts with the proteins produced from the MATN3 and COMP genes.


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