AP1S3 adaptor-related protein complex 1, sigma 3 subunit [Homo sapiens (human)]
| Gene Symbol | AP1S3 |
| Entrez Gene ID | 130340 |
| Full Name | adaptor-related protein complex 1, sigma 3 subunit |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
2 2q36.1 |
| Summary | |
| Disorder | MIM: |
| mRNA | NM_001039569, 88703050 |
| Protein | NP_001034658, 88703051 |
| Product | AP-1 complex subunit sigma-3 |
| RefSeq Status | VALIDATED |
| hsa04142 | Lysosome |
Reactome
| REACT_6185 | HIV Infection |
| REACT_6835 | The role of Nef in HIV-1 replication and disease pathogenesis |
| REACT_19287 | Lysosome Vesicle Biogenesis |
| REACT_11149 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| REACT_19400 | Golgi Associated Vesicle Biogenesis |
| REACT_11235 | trans-Golgi Network Vesicle Budding |
| REACT_19187 | Clathrin derived vesicle budding |
| REACT_11103 | Nef mediated downregulation of MHC class I complex cell surface expression |
| REACT_11123 | Membrane Trafficking |
| REACT_6288 | Host Interactions of HIV factors |
| Homo sapiens (human) | AP1S3 | NP_001034658.1 |
| Pan troglodytes (chimpanzee) | AP1S3 | XP_516121.2 |
| Canis lupus familiaris (dog) | AP1S3 | XP_536088.2 |
| Bos taurus (cattle) | AP1S3 | NP_001096766.1 |
| Mus musculus (house mouse) | Ap1s3 | NP_898848.1 |
| Gallus gallus (chicken) | AP1S3 | NP_001025179.1 |
| Danio rerio (zebrafish) | ap1s3b | NP_001004635.1 |
| Danio rerio (zebrafish) | ap1s3a | NP_001017720.1 |
| ID | Name | Evidence |
| GO:0006886 | intracellular protein transport | IEA |
| GO:0006892 | post-Golgi vesicle-mediated transport | EXP |
| GO:0006897 | endocytosis | IEA |
| GO:0016032 | viral reproduction | TAS |
| GO:0016044 | cellular membrane organization | EXP |
| GO:0050690 | regulation of defense response to virus by virus | TAS |
Component
| ID | Name | Evidence |
| GO:0000139 | Golgi membrane | TAS |
| GO:0005765 | lysosomal membrane | TAS |
| GO:0005794 | Golgi apparatus | IEA |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
| GO:0005905 | coated pit | IEA |
| GO:0016020 | membrane | IEA |
| GO:0030117 | membrane coat | IEA |
| GO:0030659 | cytoplasmic vesicle membrane | TAS |
| GO:0031410 | cytoplasmic vesicle | IEA |
Function
| ID | Name | Evidence |
| GO:0008565 | protein transporter activity | IEA |
| GeneCards | AP1S3 |
| UniProt | Q96PC3 |
| Ensembl | ENSG00000152056 |
| HGNC | 18971 |
| HPRD | 16495 |
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