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COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu55939D NM_004373 Homo sapiens cytochrome c oxidase subunit VIa polypeptide 1 (COX6A1), mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu55939C NM_004373 Homo sapiens cytochrome c oxidase subunit VIa polypeptide 1 (COX6A1), mRNA. Customized vector In-stock 5-7 Starting from $99

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Gene Symbol COX6A1
Entrez Gene ID 1337
Full Name cytochrome c oxidase subunit VIa polypeptide 1
Synonyms COX6A, COX6AL
General protein information
Preferred Names
cytochrome c oxidase subunit 6A1, mitochondrial
cytochrome c oxidase subunit 6A1, mitochondrial
cytochrome c oxidase subunit VIA-liver
cytochrome C oxidase subunit VIa homolog
cytochrome c oxidase polypeptide VIa-liver
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq, Jul 2008].

MIM: 602072

mRNA Protein Product Sequence Price Select
NM_004373, 366393043 NP_004364, 17999528 cytochrome c oxidase subunit 6A1, mitochondrial ORF Sequence $99.00
hsa00190Oxidative phosphorylation
hsa05016Huntington's disease
hsa05012Parkinson's disease
hsa05010Alzheimer's disease
hsa04260Cardiac muscle contraction
hsa_M00154Cytochrome c oxidase
hsa04932Non-alcoholic fatty liver disease (NAFLD)
WP111Electron Transport Chain
REACT_6305Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
REACT_22393Respiratory electron transport
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
Homo sapiens (human)COX6A1NP_004364.2
Pan troglodytes (chimpanzee)LOC100616508XP_003339284.1
Macaca mulatta (Rhesus monkey)LOC696956XP_002808040.1
Canis lupus familiaris (dog)LOC477508XP_534704.3
Mus musculus (house mouse)Cox6a1NP_031774.1
Rattus norvegicus (Norway rat)Cox6a1NP_036946.1
Gallus gallus (chicken)COX6A1NP_001264438.1
Danio rerio (zebrafish)cox6a1NP_001005592.1
Drosophila melanogaster (fruit fly)levyNP_611805.1
Xenopus (Silurana) tropicalis (western clawed frog)cox6a1NP_001016543.1
GO:0006091generation of precursor metabolites and energyTAS
GO:0022904respiratory electron transport chainTAS
GO:0044237cellular metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:1902600hydrogen ion transmembrane transportIEA
GO:0005743mitochondrial inner membraneTAS
GO:0005751mitochondrial respiratory chain complex IVIEA
GO:0004129cytochrome-c oxidase activityIEA
GeneCards COX6A1
UniProt H6SG15, P12074
Vega OTTHUMG00000047791
MIM 602072
Ensembl ENSG00000111775
HGNC 2277
HPRD 03644

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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