WFDC6 WAP four-disulfide core domain 6 [Homo sapiens (human)]
| Gene Symbol | WFDC6 |
| Entrez Gene ID | 140870 |
| Full Name | WAP four-disulfide core domain 6 |
| Synonyms | C20orf171, MGC126649, MGC126653, WAP6, dJ461P17.11 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
20 20q13.12 |
| Summary | This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. [provided by RefSeq]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: |
| mRNA | NM_080827, 22779935 |
| Protein | NP_543017, 22779936 |
| Product | WAP four-disulfide core domain protein 6 precursor |
| RefSeq Status | REVIEWED |
| ID | Name | Evidence |
| GO:0005576 | extracellular region | IEA |
Function
| ID | Name | Evidence |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA |
| GO:0030414 | peptidase inhibitor activity | IEA |
| GeneCards | WFDC6 |
| UniProt | Q9BQY6 |
| Ensembl | ENSG00000243543 |
| HGNC | 16164 |
| HPRD | 15677 |
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