MAPK14 mitogen-activated protein kinase 14 [Homo sapiens (human)]
| Gene Symbol | MAPK14 |
| Entrez Gene ID | 1432 |
| Full Name | mitogen-activated protein kinase 14 |
| Synonyms | CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
6 6p21.3-p21.2 |
| Summary | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]. |
| Disorder | MIM: 600289 |
| mRNA | NM_139012, 194578900 |
| Protein | NP_620581, 20986512 |
| Product | mitogen-activated protein kinase 14 isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_139014, 194578901 |
| Protein | NP_620583, 20986516 |
| Product | mitogen-activated protein kinase 14 isoform 4 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001315, 194578902 |
| Protein | NP_001306, 4503069 |
| Product | mitogen-activated protein kinase 14 isoform 1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_139013, 194578904 |
| Protein | NP_620582, 20986514 |
| Product | mitogen-activated protein kinase 14 isoform 3 |
| RefSeq Status | REVIEWED |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04370 | VEGF signaling pathway |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa04670 | Leukocyte transendothelial migration |
| hsa05145 | Toxoplasmosis |
| hsa05160 | Hepatitis C |
| hsa04912 | GnRH signaling pathway |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| hsa04660 | T cell receptor signaling pathway |
| hsa04664 | Fc epsilon RI signaling pathway |
| hsa04722 | Neurotrophin signaling pathway |
| hsa05131 | Shigellosis |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
| hsa04380 | Osteoclast differentiation |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa05140 | Leishmaniasis |
| hsa04010 | MAPK signaling pathway |
WikiPathways
| WP615 | Senescence and Autophagy |
| WP727 | Monoamine Transport |
| WP437 | EGFR1 Signaling Pathway |
| WP75 | Toll-like receptor signaling pathway |
| WP395 | IL-4 signaling Pathway |
| WP1541 | Energy Metabolism |
| WP366 | TGF-beta Receptor Signaling Pathway |
| WP286 | IL-3 Signaling Pathway |
| WP481 | Insulin Signaling |
| WP712 | Estrogen signaling pathway |
| WP127 | IL-5 Signaling Pathway |
| WP422 | MAPK Cascade |
| WP382 | MAPK signaling pathway |
| WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| WP400 | p38 MAPK Signaling Pathway |
| WP23 | B Cell Receptor Signaling Pathway |
| WP364 | IL-6 Signaling Pathway |
| WP49 | IL-2 Signaling Pathway |
| WP408 | Oxidative Stress |
Pathway Interaction Database
| nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| il12_2pathway | IL12-mediated signaling events |
| p53regulationpathway | p53 pathway |
| angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| rac1_pathway | RAC1 signaling pathway |
| faspathway | FAS (CD95) signaling pathway |
| p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| il2_1pathway | IL2-mediated signaling events |
| reg_gr_pathway | Glucocorticoid receptor regulatory network |
| p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
| il4_2pathway | IL4-mediated signaling events |
| p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| rb_1pathway | Regulation of retinoblastoma protein |
| ar_tf_pathway | Regulation of Androgen receptor activity |
| p38_mkk3_6pathway | p38 MAPK signaling pathway |
| s1p_s1p2_pathway | S1P2 pathway |
| cxcr3pathway | CXCR3-mediated signaling events |
| cd40_pathway | CD40/CD40L signaling |
| mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| rapid_gr_pathway | Rapid glucocorticoid signaling |
| atf2_pathway | ATF-2 transcription factor network |
| bcr_5pathway | BCR signaling pathway |
| cdc42_pathway | CDC42 signaling events |
| retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| il6_7pathway | IL6-mediated signaling events |
| epopathway | EPO signaling pathway |
| nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| endothelinpathway | Endothelins |
| txa2pathway | Thromboxane A2 receptor signaling |
| lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
Reactome
| REACT_6809 | MyD88-independent cascade initiated on plasma membrane |
| REACT_25281 | NFkB and MAP kinases activation mediated by TLR4 signaling repertoire |
| REACT_8005 | Toll Like Receptor TLR1:TLR2 Cascade |
| REACT_25024 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REACT_622 | Platelet activation triggers |
| REACT_25042 | Destabilization of mRNA by KSRP |
| REACT_9020 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REACT_6900 | Signaling in Immune system |
| REACT_604 | Hemostasis |
| REACT_21308 | MAP kinase activation in TLR cascade |
| REACT_12058 | Signalling to ERKs |
| REACT_12433 | Nuclear Events (kinase and transcription factor activation) |
| REACT_12065 | p38MAPK events |
| REACT_7980 | Toll Like Receptor 2 Cascade |
| REACT_798 | Platelet Activation |
| REACT_21303 | Myogenesis |
| REACT_6966 | Toll Receptor Cascades |
| REACT_19140 | ADP signalling through P2Y purinoceptor 1 |
| REACT_20605 | Metabolism of mRNA |
| REACT_25222 | MyD88 dependent cascade initiated on endosome |
| REACT_25299 | DSCAM interactions |
| REACT_20524 | Signal amplification |
| REACT_21402 | CDO in myogenesis |
| REACT_12599 | ERK/MAPK targets |
| REACT_21257 | Metabolism of RNA |
| REACT_11061 | Signalling by NGF |
| REACT_21399 | activated TAK1 mediates p38 MAPK activation |
| REACT_23879 | Platelet sensitization by LDL |
| REACT_24994 | Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| REACT_6783 | Toll Like Receptor 3 (TLR3) Cascade |
| REACT_21326 | Activation of the AP-1 family of transcription factors |
| REACT_6894 | Toll Like Receptor 4 (TLR4) Cascade |
| REACT_6890 | Activated TLR4 signalling |
| REACT_6782 | TRAF6 Mediated Induction of proinflammatory cytokines |
| REACT_12056 | NGF signalling via TRKA from the plasma membrane |
| REACT_6788 | MyD88:Mal cascade initiated on plasma membrane |
| REACT_23876 | Platelet homeostasis |
| REACT_21328 | MAPK targets/ Nuclear events mediated by MAP kinases |
| REACT_8006 | Toll Like Receptor TLR6:TLR2 Cascade |
| REACT_20 | Formation of Platelet plug |
| REACT_9047 | Toll Like Receptor 9 (TLR9) Cascade |
| REACT_23853 | Interactions of the immunoglobulin superfamily (IgSF) member proteins |
| REACT_6802 | Innate Immunity Signaling |
| REACT_12033 | Signalling to RAS |
| Homo sapiens (human) | MAPK14 | NP_001306.1 |
| Pan troglodytes (chimpanzee) | MAPK14 | NP_001009065.1 |
| Canis lupus familiaris (dog) | MAPK14 | NP_001003206.1 |
| Bos taurus (cattle) | MAPK14 | NP_001095644.1 |
| Mus musculus (house mouse) | Mapk14 | NP_036081.1 |
| Rattus norvegicus (Norway rat) | Mapk14 | NP_112282.2 |
| Gallus gallus (chicken) | MAPK14 | XP_419263.2 |
| Danio rerio (zebrafish) | mapk14a | NP_571797.1 |
| Drosophila melanogaster (fruit fly) | p38b | NP_477361.1 |
| Drosophila melanogaster (fruit fly) | Mpk2 | NP_001163711.1 |
| Caenorhabditis elegans | pmk-1 | NP_501365.1 |
| Arabidopsis thaliana (thale cress) | ATMPK3 | NP_190150.1 |
| ID | Name | Evidence |
| GO:0000187 | activation of MAPK activity | TAS |
| GO:0002224 | toll-like receptor signaling pathway | TAS |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | EXP |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | EXP |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS |
| GO:0006928 | cellular component movement | TAS |
| GO:0006935 | chemotaxis | TAS |
| GO:0006950 | response to stress | IDA |
| GO:0007165 | signal transduction | TAS |
| GO:0007166 | cell surface receptor linked signaling pathway | TAS |
| GO:0007243 | intracellular protein kinase cascade | IDA |
| GO:0007265 | Ras protein signal transduction | EXP |
| GO:0007596 | blood coagulation | TAS |
| GO:0008063 | Toll signaling pathway | TAS |
| GO:0016070 | RNA metabolic process | TAS |
| GO:0016071 | mRNA metabolic process | TAS |
| GO:0030168 | platelet activation | TAS |
| GO:0034130 | toll-like receptor 1 signaling pathway | TAS |
| GO:0034134 | toll-like receptor 2 signaling pathway | TAS |
| GO:0034138 | toll-like receptor 3 signaling pathway | TAS |
| GO:0034142 | toll-like receptor 4 signaling pathway | TAS |
| GO:0042692 | muscle cell differentiation | TAS |
| GO:0042770 | signal transduction in response to DNA damage | IMP |
| GO:0045087 | innate immune response | TAS |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS |
| GO:0051090 | regulation of sequence-specific DNA binding transcription factor activity | TAS |
| GO:0051149 | positive regulation of muscle cell differentiation | EXP |
| GO:0051403 | stress-activated MAPK cascade | TAS |
| GO:0071479 | cellular response to ionizing radiation | IMP |
| GO:0090400 | stress-induced premature senescence | IMP |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process | IMP |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | ISS |
| GO:0005654 | nucleoplasm | EXP |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005737 | cytoplasm | ISS |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004674 | protein serine/threonine kinase activity | EXP |
| GO:0004674 | protein serine/threonine kinase activity | TAS |
| GO:0004707 | MAP kinase activity | IDA |
| GO:0004708 | MAP kinase kinase activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GeneCards | MAPK14 |
| PDB | 2BAJ, 1WBO, 2NPQ, 3HA8, 3MH0, 3FLN, 1YQJ, 3L8X, 3HV3, 1WBT, 3GCU, 3HEC, 3NNV, 3HV7, 1ZZ2, 1DI9, 3NNX, 3FML, 3KF7, 3GI3, 3HUC, 1M7Q, 3OEF, 2BAK, 3BV2, 3NWW, 2GFS, 3FLZ, 3IW5, 3FMH, 2FSO, 1KV1, 3E92, 3HVC, 2ZAZ, 3FI4, 3DS6, 1ZZL, 1WFC, 3FL4, 3IW8, 1W7H, 3FSF, 3OBG, 3HEG, 3FLS, 3FKL, 3BX5, 1ZYJ, 3MH1, 2FSL, 3MH2, 3HP5, 2I0H, 2RG5, 2BAQ, 1WBV, 2ZB0, 3FMJ, 3HRB, 3NEW, 1BL6, 1IAN, 1OZ1, 3HV4, 2QD9, 3K3J, 1OUY, 3E93, 1WBW, 3HLL, 3OD6, 1W82, 3O8T, 3KQ7, 1OVE, 1W84, 3C5U, 1KV2, 1BMK, 3NNW, 3FMN, 3DT1, 3O8P, 1A9U, 3GCS, 3FMM, 3FLW, 3IPH, 3GCV, 3MGY, 3FLQ, 3GFE, 2FSM, 3FKN, 2RG6, 1WBN, 3GC7, 3ODZ, 3HV6, 3OCG, 2BAL, 3BV3, 3OBJ, 3CTQ, 3MH3, 3MVL, 3D7Z, 3IW6, 3FMK, 2FST, 3FLY, 1BL7, 3K3I, 3MPT, 3IW7, 3ODY, 3FC1, 2ONL, 2OKR, 3ITZ, 3HUB, 3L8S, 1W83, 3HL7, 3FKO, 3MVM, 3LHJ, 1WBS, 1OUK, 3GCQ, 3OC1, 3GCP, 3FSK, 3MPA, 1R39, 3NNU, 3D83, 2ZB1, 3HV5, 3O8U, 1R3C, 3HP2 |
| UniProt | Q16539 |
| MIM | 600289 |
| Ensembl | ENSG00000112062 |
| HGNC | 6876 |
| HPRD | 02619 |
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