Sequence in raw or FASTA format:
MESP2 mesoderm posterior 2 homolog (mouse) [Homo sapiens (human)]
| Gene Symbol | MESP2 |
| Entrez Gene ID | 145873 |
| Full Name | mesoderm posterior 2 homolog (mouse) |
| Synonyms | SCDO2, bHLHc6 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
15 15q26.1 |
| Summary | This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq]. |
| Disorder | MIM: 605195 Spondylocostal dysostosis, autosomal recessive 2, 608681 (3) |
| mRNA | NM_001039958, 90403597 |
| Protein | NP_001035047, 90403598 |
| Product | mesoderm posterior protein 2 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | MESP2 | NP_001035047.1 |
| Pan troglodytes (chimpanzee) | MESP2 | XP_523152.2 |
| Bos taurus (cattle) | MESP2 | XP_871971.1 |
| Mus musculus (house mouse) | Mesp2 | NP_032615.2 |
| Rattus norvegicus (Norway rat) | Mesp2 | XP_218825.4 |
| Gallus gallus (chicken) | MESP2 | NP_989897.1 |
| Gallus gallus (chicken) | MESP2 | XP_001231219.1 |
| ID | Name | Evidence |
| GO:0001756 | somitogenesis | IEA |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA |
| GO:0007219 | Notch signaling pathway | IEA |
| GO:0007275 | multicellular organismal development | IEA |
| GO:0008078 | mesodermal cell migration | IEA |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
Function
| ID | Name | Evidence |
| GO:0003677 | DNA binding | IEA |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | IEA |
| GeneCards | MESP2 |
| UniProt | Q0VG99 |
| MIM | 605195 |
| Ensembl | ENSG00000188095 |
| HGNC | 29659 |
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