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MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28715 NM_001039958 Homo sapiens mesoderm posterior basic helix-loop-helix transcription factor 2 (MESP2), mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu28715C NM_001039958 Homo sapiens mesoderm posterior basic helix-loop-helix transcription factor 2 (MESP2), mRNA. Customized vector On-demand TBD $269.00

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Gene Symbol MESP2
Entrez Gene ID 145873
Full Name mesoderm posterior basic helix-loop-helix transcription factor 2
Synonyms SCDO2, bHLHc6
General protein information
Preferred Names
mesoderm posterior protein 2
Names
mesoderm posterior protein 2
class C basic helix-loop-helix protein 6
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q26.1

Summary This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008].
Disorder

MIM: 605195

Spondylocostal dysostosis, autosomal recessive 2, 608681 (3)

mRNA Protein Product Sequence Price Select
NM_001039958, 90403597 NP_001035047, 90403598 mesoderm posterior protein 2 ORF Sequence $400.00
WikiPathways
WP2406Cardiac Progenitor Differentiation
Homo sapiens (human)MESP2NP_001035047.1
Pan troglodytes (chimpanzee)MESP2XP_523152.2
Macaca mulatta (Rhesus monkey)MESP2XP_001093605.1
Canis lupus familiaris (dog)MESP2XP_003434391.1
Bos taurus (cattle)MESP2XP_002696623.1
Mus musculus (house mouse)Mesp2NP_032615.2
Rattus norvegicus (Norway rat)Mesp2NP_001099743.1
Process
IDNameEvidence
GO:0001756somitogenesisIEA
GO:0006351transcription, DNA-templatedIEA
GO:0007219Notch signaling pathwayIEA
GO:0008078mesodermal cell migrationIEA
GO:0023019signal transduction involved in regulation of gene expressionIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0003677DNA bindingIEA
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0046983protein dimerization activityIEA
GeneCards MESP2
UniProt Q0VG99
Vega OTTHUMG00000172016
MIM 605195
Ensembl ENSG00000188095
HGNC 29659

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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