Sequence in raw or FASTA format:
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 [Homo sapiens (human)]
|Entrez Gene ID||145873|
|Full Name||mesoderm posterior basic helix-loop-helix transcription factor 2|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008].|
Spondylocostal dysostosis, autosomal recessive 2, 608681 (3)
|WP2406||Cardiac Progenitor Differentiation|
|Homo sapiens (human)||MESP2||NP_001035047.1|
|Pan troglodytes (chimpanzee)||MESP2||XP_523152.2|
|Macaca mulatta (Rhesus monkey)||MESP2||XP_001093605.1|
|Canis lupus familiaris (dog)||MESP2||XP_003434391.1|
|Bos taurus (cattle)||MESP2||XP_002696623.1|
|Mus musculus (house mouse)||Mesp2||NP_032615.2|
|Rattus norvegicus (Norway rat)||Mesp2||NP_001099743.1|
|GO:0007219||Notch signaling pathway||IEA|
|GO:0008078||mesodermal cell migration||IEA|
|GO:0023019||signal transduction involved in regulation of gene expression||IEA|
|GO:0045944||positive regulation of transcription from RNA polymerase II promoter||IEA|
|GO:0070062||extracellular vesicular exosome||IDA|
|GO:0003700||sequence-specific DNA binding transcription factor activity||IEA|
|GO:0046983||protein dimerization activity||IEA|
What is the normal function of the MESP2 gene?
The MESP2 gene provides instructions for making a transcription factor, which is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. The MESP2 protein controls the activity of genes in the Notch pathway, an important pathway in embryonic development. The Notch pathway plays a critical role in the development of vertebrae. Specifically, the MESP2 protein and the Notch pathway are involved in separating future vertebrae from one another during early development, a complex process called somite segmentation. Although the exact mechanism of somite segmentation is unclear, it appears to require the activity of several proteins in the Notch pathway, including the NOTCH1 protein and the MESP2 protein, to be turned on and off in a specific pattern (oscillate).
The MESP2 protein regulates Notch activity by turning on (activating) genes in the Notch pathway, which ultimately block (repress) the activity of the NOTCH1 protein. Additionally, through unknown mechanisms, the MESP2 protein seems to mark the boundary separating future vertebrae from one another.
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