Sequence in raw or FASTA format:
CDAN1 codanin 1 [Homo sapiens (human)]
|Entrez Gene ID||146059|
|Full Name||codanin 1|
|Synonyms||CDA1, CDAI, CDAN1A, DLT, PRO1295|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009].|
Anemia, congenital dyserythropoietic, type I, 224120 (3)
|Homo sapiens (human)||CDAN1||NP_612486.2|
|Pan troglodytes (chimpanzee)||CDAN1||XP_003952692.1|
|Macaca mulatta (Rhesus monkey)||CDAN1||XP_001105436.1|
|Canis lupus familiaris (dog)||CDAN1||XP_005638738.1|
|Bos taurus (cattle)||CDAN1||XP_002690857.1|
|Mus musculus (house mouse)||Cdan1||NP_081167.2|
|Rattus norvegicus (Norway rat)||Cdan1||XP_003749607.2|
|Gallus gallus (chicken)||CDAN1||XP_004941710.1|
|Danio rerio (zebrafish)||cdan1||XP_693684.6|
|Drosophila melanogaster (fruit fly)||dlt||NP_728672.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||cdan1||XP_002941131.2|
|GO:0008156||negative regulation of DNA replication||IMP|
|GO:0016021||integral component of membrane||IEA|
What is the normal function of the CDAN1 gene?
The CDAN1 gene provides instructions for making a protein called codanin-1. Although this protein is active in cells throughout the body, very little is known about its function.
A recent study suggests that codanin-1 is associated with a form of DNA called heterochromatin. Heterochromatin is densely packed DNA that contains few functional genes, but it plays an important role in maintaining the structure of the nucleus (where most of the cell's DNA is located).
Researchers speculate that codanin-1 may be involved in the formation of red blood cells, a process called erythropoiesis. Specifically, this protein may play a key role in the organization of heterochromatin during the division of these developing cells.
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