Hras1 Harvey rat sarcoma virus oncogene 1 [Mus musculus (house mouse)]
| Gene Symbol | Hras1 |
| Entrez Gene ID | 15461 |
| Full Name | Harvey rat sarcoma virus oncogene 1 |
| Synonyms | H-ras, Ha-ras, Harvey-ras, Hras-1, Kras2, c-H-ras, c-Ha-ras, c-rasHa, ras |
| Gene Type | protein-coding |
| Organism | Mus musculus (house mouse) |
| Genome |
7 7 F5|7 72.2 cM |
| Summary | |
| Disorder | MIM: |
| mRNA | NM_008284, 194440733 |
| Protein | NP_032310, 194440734 |
| Product | GTPase HRas isoform 1 |
| RefSeq Status | VALIDATED |
| mRNA | NM_001130443, 194363763 |
| Protein | NP_001123915, 194363764 |
| Product | GTPase HRas isoform 1 |
| RefSeq Status | VALIDATED |
| mRNA | NM_001130444, 194363765 |
| Protein | NP_001123916, 194363766 |
| Product | GTPase HRas isoform 2 |
| RefSeq Status | VALIDATED |
| mmu04722 | Neurotrophin signaling pathway |
| mmu05214 | Glioma |
| mmu04012 | ErbB signaling pathway |
| mmu05219 | Bladder cancer |
| mmu04916 | Melanogenesis |
| mmu05216 | Thyroid cancer |
| mmu04370 | VEGF signaling pathway |
| mmu04720 | Long-term potentiation |
| mmu05223 | Non-small cell lung cancer |
| mmu05221 | Acute myeloid leukemia |
| mmu04360 | Axon guidance |
| mmu05200 | Pathways in cancer |
| mmu04664 | Fc epsilon RI signaling pathway |
| mmu05213 | Endometrial cancer |
| mmu04010 | MAPK signaling pathway |
| mmu05220 | Chronic myeloid leukemia |
| mmu04530 | Tight junction |
| mmu04660 | T cell receptor signaling pathway |
| mmu04062 | Chemokine signaling pathway |
| mmu04144 | Endocytosis |
| mmu05211 | Renal cell carcinoma |
| mmu04810 | Regulation of actin cytoskeleton |
| mmu05160 | Hepatitis C |
| mmu04730 | Long-term depression |
| mmu04662 | B cell receptor signaling pathway |
| mmu04540 | Gap junction |
| mmu04912 | GnRH signaling pathway |
| mmu05218 | Melanoma |
| mmu04510 | Focal adhesion |
| mmu04650 | Natural killer cell mediated cytotoxicity |
| mmu05215 | Prostate cancer |
| mmu04910 | Insulin signaling pathway |
WikiPathways
| WP407 | Kit Receptor Signaling Pathway |
| WP297 | IL-7 Signaling Pathway |
| WP350 | p38 MAPK Signaling Pathway (BioCarta) |
| WP151 | IL-5 Signaling Pathway |
| WP232 | G Protein Signaling Pathways |
| WP1267 | Senescence and Autophagy |
| WP572 | EGFR1 Signaling Pathway |
| WP65 | Insulin Signaling |
| WP1261 | ErbB signaling pathway |
| WP113 | TGF Beta Signaling Pathway |
| WP193 | Signaling of Hepatocyte Growth Factor Receptor |
| WP1763 | PluriNetWork |
| WP251 | MAPK Cascade |
| WP387 | IL-6 signaling Pathway |
| WP373 | IL-3 Signaling Pathway |
| WP6 | Integrin-mediated cell adhesion |
Reactome
| 1210691 | Interleukin-3, 5 and GM-CSF signaling |
| 1210190 | Signalling by NGF |
| 1210690 | Interleukin receptor SHC signaling |
| 1210297 | Axon guidance |
| 1210204 | SHC-mediated signalling |
| 1210289 | RAF activation |
| 1210398 | Hemostasis |
| 1210302 | ARMS-mediated activation |
| 1210205 | Signalling to RAS |
| 1210408 | Cell surface interactions at the vascular wall |
| 1210312 | Signaling in Immune system |
| 1210299 | MAP kinase cascade |
| 1210200 | IRS-mediated signalling |
| 1210293 | Down-stream signal transduction |
| 1210199 | SOS-mediated signalling |
| 1210301 | Prolonged ERK activation events |
| 1210291 | Signaling by EGFR |
| 1210195 | Signaling by Insulin receptor |
| 1210294 | Signaling by PDGF |
| 1210300 | Frs2-mediated activation |
| 1210189 | NGF signalling via TRKA from the plasma membrane |
| 1210290 | Grb2 events in EGFR signaling |
| 1210303 | RAF phosphorylates MEK |
| 1210203 | SHC-related events |
| 1210292 | Shc events in EGFR signaling |
| 1210206 | Signalling to ERKs |
| 1210197 | IRS-related events |
| 1210296 | NCAM signaling for neurite out-growth |
| 1210560 | p38MAPK events |
| 1210295 | Signalling to p38 via RIT and RIN |
| 1210543 | Signaling by Interleukins |
| 1210194 | Insulin receptor signalling cascade |
| 1210734 | Tie2 Signaling |
| 1210298 | MEK activation |
| Homo sapiens (human) | HRAS | NP_001123914.1 |
| Pan troglodytes (chimpanzee) | HRAS | XP_521702.2 |
| Mus musculus (house mouse) | Hras1 | NP_032310.1 |
| Rattus norvegicus (Norway rat) | Hras | XP_001061671.1 |
| Gallus gallus (chicken) | HRAS | NP_990623.1 |
| Danio rerio (zebrafish) | hrasa | NP_001017623.1 |
| Danio rerio (zebrafish) | LOC100151000 | XP_001923439.1 |
| Danio rerio (zebrafish) | hrasb | NP_001018465.1 |
| ID | Name | Evidence |
| GO:0006184 | GTP catabolic process | IEA |
| GO:0006897 | endocytosis | IDA |
| GO:0006915 | apoptosis | ISO |
| GO:0006917 | induction of apoptosis | IGI |
| GO:0007050 | cell cycle arrest | ISO |
| GO:0007165 | signal transduction | IEA |
| GO:0007264 | small GTPase mediated signal transduction | IDA |
| GO:0007264 | small GTPase mediated signal transduction | ISO |
| GO:0007265 | Ras protein signal transduction | ISO |
| GO:0007265 | Ras protein signal transduction | TAS |
| GO:0007569 | cell aging | IDA |
| GO:0008283 | cell proliferation | IPI |
| GO:0008284 | positive regulation of cell proliferation | IDA |
| GO:0008284 | positive regulation of cell proliferation | ISO |
| GO:0008285 | negative regulation of cell proliferation | ISO |
| GO:0008629 | induction of apoptosis by intracellular signals | IMP |
| GO:0031575 | mitotic cell cycle G1/S transition checkpoint | ISO |
| GO:0043410 | positive regulation of MAPKKK cascade | ISO |
| GO:0043524 | negative regulation of neuron apoptosis | IDA |
| GO:0043524 | negative regulation of neuron apoptosis | IGI |
| GO:0045740 | positive regulation of DNA replication | ISO |
| GO:0046579 | positive regulation of Ras protein signal transduction | ISO |
| GO:0048169 | regulation of long-term neuronal synaptic plasticity | IMP |
| GO:0050679 | positive regulation of epithelial cell proliferation | ISO |
| GO:0051291 | protein heterooligomerization | ISO |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISO |
| GO:0090398 | cellular senescence | ISO |
Component
| ID | Name | Evidence |
| GO:0005622 | intracellular | IEA |
| GO:0005625 | soluble fraction | ISO |
| GO:0005792 | microsome | ISO |
| GO:0005794 | Golgi apparatus | IEA |
| GO:0005829 | cytosol | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0016020 | membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0003924 | GTPase activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005525 | GTP binding | IDA |
| GO:0005525 | GTP binding | ISO |
| GO:0008022 | protein C-terminus binding | ISO |
| GeneCards | Hras1 |
| UniProt | Q76LV5, E9Q2E0, Q6P716 |
| MGI | 96224 |
| Ensembl | ENSMUSG00000025499 |
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