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Sequence in raw or FASTA format:

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FREM1 FRAS1 related extracellular matrix 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001177704 Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_144966 Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $3749.00 35
XM_005251382 PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $3749.00 35
XM_005251383 PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005251384 PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006716723 PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $3749.00 35
XM_006716724 PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_006716725 PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_006716726 PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006716727 PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006716728 PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006716729 PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant X10, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

Related Services

Gene Symbol FREM1
Entrez Gene ID 158326
Full Name FRAS1 related extracellular matrix 1
Synonyms BNAR, C9orf143, C9orf145, C9orf154, MOTA, TILRR, TRIGNO2
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9p22.3

Summary This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation. [provided by RefSeq, Apr 2011].
Disorder

MIM: 608944

Bifid nose with or without anorectal and renal anomalies, 608980 (3)

mRNA Protein Product Sequence Price Select
NM_001177704, 295293181 NP_001171175, 295293182 FRAS1-related extracellular matrix protein 1 isoform 2 ORF Sequence $700.00
NM_144966, 295293180 NP_659403, 122056683 FRAS1-related extracellular matrix protein 1 isoform 1 precursor ORF Sequence $3500.00
XM_005251382, 578816381 XP_005251439, 530389734 FRAS1-related extracellular matrix protein 1 isoform X1 ORF Sequence $3500.00
XM_005251383, 578816394 XP_005251440, 530389736 FRAS1-related extracellular matrix protein 1 isoform X2 ORF Sequence $700.00
XM_005251384, 578816395 XP_005251441, 530389738 FRAS1-related extracellular matrix protein 1 isoform X3 ORF Sequence $700.00
XM_006716723, 578816382 XP_006716786, 578816383 FRAS1-related extracellular matrix protein 1 isoform X4 ORF Sequence $3500.00
XM_006716724, 578816384 XP_006716787, 578816385 FRAS1-related extracellular matrix protein 1 isoform X5 ORF Sequence $2500.00
XM_006716725, 578816386 XP_006716788, 578816387 FRAS1-related extracellular matrix protein 1 isoform X6 ORF Sequence $2500.00
XM_006716726, 578816388 XP_006716789, 578816389 FRAS1-related extracellular matrix protein 1 isoform X7 ORF Sequence $1500.00
XM_006716727, 578816390 XP_006716790, 578816391 FRAS1-related extracellular matrix protein 1 isoform X8 ORF Sequence $1500.00
XM_006716728, 578816392 XP_006716791, 578816393 FRAS1-related extracellular matrix protein 1 isoform X9 ORF Sequence $1500.00
XM_006716729, 578816396 XP_006716792, 578816397 FRAS1-related extracellular matrix protein 1 isoform X10 ORF Sequence $700.00
Homo sapiens (human)FREM1NP_659403.4
Pan troglodytes (chimpanzee)FREM1XP_520492.3
Macaca mulatta (Rhesus monkey)FREM1XP_001110764.1
Canis lupus familiaris (dog)FREM1XP_005626693.1
Bos taurus (cattle)FREM1NP_001179924.1
Mus musculus (house mouse)Frem1NP_001185740.1
Rattus norvegicus (Norway rat)Frem1NP_001178686.1
Gallus gallus (chicken)FREM1XP_424932.2
Danio rerio (zebrafish)frem1aNP_001177237.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100488523XP_002939136.2
Process
IDNameEvidence
GO:0007154cell communicationIEA
GO:0007160cell-matrix adhesionIEA
GO:0097094craniofacial suture morphogenesisIMP
Component
IDNameEvidence
GO:0005604basement membraneIEA
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0030246carbohydrate bindingIEA
GO:0046872metal ion bindingIEA
GeneCards FREM1
UniProt Q5H8C1
Vega OTTHUMG00000019575
MIM 608944
Ensembl ENSG00000164946
HGNC 23399
HPRD 09865

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FREM1 gene?

The FREM1 gene provides instructions for making a protein that is involved in the formation and organization of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues.

The FREM1 protein is one of a group of proteins, including proteins called FRAS1 and FREM2, that interact during embryonic development as components of basement membranes. Basement membranes help anchor layers of cells lining the surfaces and cavities of the body (epithelial cells) to other embryonic tissues, including those that give rise to connective tissues (such as skin and cartilage) and the kidneys.

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