Sequence in raw or FASTA format:
STRC stereocilin [Homo sapiens (human)]
|Entrez Gene ID||161497|
|General protein information|
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. [provided by RefSeq, Jul 2008].|
Deafness, autosomal recessive 16, 603720 (3)
|Homo sapiens (human)||STRC||NP_714544.1|
|Pan troglodytes (chimpanzee)||LOC100608534||XP_003314689.1|
|Pan troglodytes (chimpanzee)||STRC||XP_510640.3|
|Macaca mulatta (Rhesus monkey)||STRC||XP_001108232.2|
|Canis lupus familiaris (dog)||STRC||XP_535452.2|
|Bos taurus (cattle)||STRC||XP_002696795.1|
|Mus musculus (house mouse)||Strc||NP_536707.2|
|Rattus norvegicus (Norway rat)||Strc||XP_001080205.2|
|Danio rerio (zebrafish)||LOC100004499||XP_001343792.4|
|Xenopus (Silurana) tropicalis (western clawed frog)||strc||XP_002932308.2|
|GO:0050910||detection of mechanical stimulus involved in sensory perception of sound||IEA|
|GO:0060088||auditory receptor cell stereocilium organization||ISS|
|GO:0032426||stereocilium bundle tip||ISS|
What is the normal function of the STRC gene?
The STRC gene provides instructions for making a protein called stereocilin. This protein is found in the inner ear and may be involved in hearing. Hearing requires the conversion of sound waves to nerve impulses that are transmitted via the auditory nerve to the brain. Stereocilin may play a role in this conversion process. Studies indicate that stereocilin is associated with hair-like structures called stereocilia. Stereocilia project from specialized cells called hair cells and bend in response to sound waves. This bending motion triggers a series of reactions that generate a nerve impulse. Although the exact function of the stereocilin protein is unknown, it appears to be important for normal hearing.
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