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STRC stereocilin [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_153700 Homo sapiens stereocilin (STRC), mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006720407 PREDICTED: Homo sapiens stereocilin (STRC), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Related Services

Gene Symbol STRC
Entrez Gene ID 161497
Full Name stereocilin
Synonyms DFNB16
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q15.3

Summary This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. [provided by RefSeq, Jul 2008].
Disorder

MIM: 606440

Deafness, autosomal recessive 16, 603720 (3)

mRNA Protein Product Sequence Price Select
NM_153700, 31559780 NP_714544, 24308527 stereocilin precursor ORF Sequence $2500.00
XM_006720407, 578826656 XP_006720470, 578826657 stereocilin isoform X1 ORF Sequence $1500.00
Homo sapiens (human)STRCNP_714544.1
Pan troglodytes (chimpanzee)LOC100608534XP_003314689.1
Pan troglodytes (chimpanzee)STRCXP_510640.3
Macaca mulatta (Rhesus monkey)STRCXP_001108232.2
Canis lupus familiaris (dog)STRCXP_535452.2
Bos taurus (cattle)STRCXP_002696795.1
Mus musculus (house mouse)StrcNP_536707.2
Rattus norvegicus (Norway rat)StrcXP_001080205.2
Danio rerio (zebrafish)LOC100004499XP_001343792.4
Xenopus (Silurana) tropicalis (western clawed frog)strcXP_002932308.2
Process
IDNameEvidence
GO:0050910detection of mechanical stimulus involved in sensory perception of soundIEA
GO:0060088auditory receptor cell stereocilium organizationISS
Component
IDNameEvidence
GO:0009986cell surfaceIEA
GO:0032420stereociliumIEA
GO:0032426stereocilium bundle tipISS
GO:0060091kinociliumISS
GeneCards STRC
UniProt Q7RTU9
Vega OTTHUMG00000059899
MIM 606440
Ensembl ENSG00000242866
HGNC 16035
HPRD 08403

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the STRC gene?

The STRC gene provides instructions for making a protein called stereocilin. This protein is found in the inner ear and may be involved in hearing. Hearing requires the conversion of sound waves to nerve impulses that are transmitted via the auditory nerve to the brain. Stereocilin may play a role in this conversion process. Studies indicate that stereocilin is associated with hair-like structures called stereocilia. Stereocilia project from specialized cells called hair cells and bend in response to sound waves. This bending motion triggers a series of reactions that generate a nerve impulse. Although the exact function of the stereocilin protein is unknown, it appears to be important for normal hearing.

Interactant

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