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Sequence in raw or FASTA format:

Database:

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Il7r interleukin 7 receptor [Mus musculus (house mouse)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_008372 Mus musculus interleukin 7 receptor (Il7r), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol Il7r
Entrez Gene ID 16197
Full Name interleukin 7 receptor
Synonyms CD127, IL-7Ralpha
General protein information
Preferred Names
interleukin-7 receptor subunit alpha
Names
interleukin-7 receptor subunit alpha
IL-7RA
IL-7R-alpha
IL-7R subunit alpha
IL-7 receptor alpha chain
IL-7 receptor subunit alpha
interleukin 7 receptor alpha chain
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

15

15 A1|15 4.16 cM

Summary Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008].
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_008372, 168480108 NP_032398, 45269152 interleukin-7 receptor subunit alpha precursor ORF Sequence $550.00
KEGG
mmu04060Cytokine-cytokine receptor interaction
mmu04640Hematopoietic cell lineage
mmu04630Jak-STAT signaling pathway
mmu05340Primary immunodeficiency
mmu04151PI3K-Akt signaling pathway
mmu04068FoxO signaling pathway
WikiPathways
WP297IL-7 Signaling Pathway
WP2309XPodNet - protein-protein interactions in the podocyte expanded by STRING
Reactome
5605676Interleukin-7 signaling
5604803Immune System
5604927Cytokine Signaling in Immune system
5604926Signaling by Interleukins
Homo sapiens (human)IL7RNP_002176.2
Pan troglodytes (chimpanzee)IL7RXP_517807.2
Macaca mulatta (Rhesus monkey)IL7RXP_001092582.1
Canis lupus familiaris (dog)IL7RXP_855408.1
Bos taurus (cattle)IL7RNP_001192816.1
Mus musculus (house mouse)Il7rNP_032398.3
Rattus norvegicus (Norway rat)Il7rNP_001099888.1
Gallus gallus (chicken)IL7RNP_001073575.1
Process
IDNameEvidence
GO:0000902cell morphogenesisIGI
GO:0001915negative regulation of T cell mediated cytotoxicityIMP
GO:0002377immunoglobulin productionIGI
GO:0008361regulation of cell sizeIDA
GO:0008361regulation of cell sizeIGI
GO:0010628positive regulation of gene expressionIMP
GO:0016049cell growthIMP
GO:0030217T cell differentiationIMP
GO:0033089positive regulation of T cell differentiation in thymusIMP
GO:0042100B cell proliferationIGI
GO:0042100B cell proliferationIMP
GO:0048535lymph node developmentIMP
GO:0048872homeostasis of number of cellsIGI
GO:0048872homeostasis of number of cellsIMP
Component
IDNameEvidence
GO:0009897external side of plasma membraneIDA
GO:0016020membraneIEA
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0004896cytokine receptor activityIEA
GeneCards Il7r
PDB 4NN7, 4NN6, 4NN5
UniProt Q8C9W4, Q5FW78, P16872
MGI 96562
Ensembl ENSMUSG00000003882

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

What is the normal function of the IL7R gene?

The IL7R gene provides instructions for making a protein called interleukin 7 (IL-7) receptor alpha chain. This protein is one piece of both the IL-7 receptor and the thymic stromal lymphopoietin (TSLP) receptor. These receptors are embedded in the cell membrane of immune system cells. The IL-7 receptor is found in B cells and T cells as well as the early blood-forming cells that give rise to them. The TSLP receptor is found in several types of immune cells, including B cells, T cells, monocytes, and dendritic cells. These cells identify foreign substances and defend the body against infection and disease.

At the cell surface, the IL-7 receptor interacts with a protein called IL-7. IL-7 is a cytokine, which is a protein that regulates the activity of immune system cells. The receptor and cytokine fit together like a lock and its key, triggering a series of chemical signals inside the cell. In early blood-forming cells, signaling through the IL-7 receptor ensures the development of mature B cells and T cells. IL-7 receptor signaling also stimulates the later growth and division (proliferation) and survival of these cells.

Similarly, the TSLP receptor interacts with the cytokine TSLP. Attachment of TSLP to its receptor triggers a set of signals that support proliferation and maturation of a variety of immune system cells.

Interactant

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