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Il7r interleukin 7 receptor [Mus musculus (house mouse)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OMu22595 NM_008372 Mus musculus interleukin 7 receptor (Il7r), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OMu22595C NM_008372 Mus musculus interleukin 7 receptor (Il7r), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol Il7r
Entrez Gene ID 16197
Full Name interleukin 7 receptor
Synonyms CD127, IL-7Ralpha
General protein information
Preferred Names
interleukin-7 receptor subunit alpha
Names
interleukin-7 receptor subunit alpha
IL-7RA
IL-7R-alpha
IL-7R subunit alpha
IL-7 receptor alpha chain
IL-7 receptor subunit alpha
interleukin 7 receptor alpha chain
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

15

15 A1|15 4.16 cM

Summary Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008].
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_008372, 168480108 NP_032398, 45269152 interleukin-7 receptor subunit alpha precursor ORF Sequence $550.00
KEGG
mmu04060Cytokine-cytokine receptor interaction
mmu04640Hematopoietic cell lineage
mmu04630Jak-STAT signaling pathway
mmu05340Primary immunodeficiency
mmu04151PI3K-Akt signaling pathway
mmu04068FoxO signaling pathway
WikiPathways
WP297IL-7 Signaling Pathway
WP2309XPodNet - protein-protein interactions in the podocyte expanded by STRING
Reactome
5605676Interleukin-7 signaling
5604803Immune System
5604927Cytokine Signaling in Immune system
5604926Signaling by Interleukins
Homo sapiens (human)IL7RNP_002176.2
Pan troglodytes (chimpanzee)IL7RXP_517807.2
Macaca mulatta (Rhesus monkey)IL7RXP_001092582.1
Canis lupus familiaris (dog)IL7RXP_855408.1
Bos taurus (cattle)IL7RNP_001192816.1
Mus musculus (house mouse)Il7rNP_032398.3
Rattus norvegicus (Norway rat)Il7rNP_001099888.1
Gallus gallus (chicken)IL7RNP_001073575.1
Process
IDNameEvidence
GO:0000902cell morphogenesisIGI
GO:0001915negative regulation of T cell mediated cytotoxicityIMP
GO:0002377immunoglobulin productionIGI
GO:0008361regulation of cell sizeIDA
GO:0008361regulation of cell sizeIGI
GO:0010628positive regulation of gene expressionIMP
GO:0016049cell growthIMP
GO:0030217T cell differentiationIMP
GO:0033089positive regulation of T cell differentiation in thymusIMP
GO:0042100B cell proliferationIGI
GO:0042100B cell proliferationIMP
GO:0048535lymph node developmentIMP
GO:0048872homeostasis of number of cellsIGI
GO:0048872homeostasis of number of cellsIMP
Component
IDNameEvidence
GO:0009897external side of plasma membraneIDA
GO:0016020membraneIEA
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0004896cytokine receptor activityIEA
GeneCards Il7r
PDB 4NN7, 4NN6, 4NN5
UniProt Q8C9W4, Q5FW78, P16872
MGI 96562
Ensembl ENSMUSG00000003882

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactant

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