Smad3 MAD homolog 3 (Drosophila) [Mus musculus (house mouse)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	Smad3
Entrez Gene ID	17127
Full Name	MAD homolog 3 (Drosophila)
Synonyms	AU022421, Madh3
Gene Type	protein-coding
Organism	Mus musculus (house mouse)
Genome	Chromosome:9 Map Location:9 D\|9
Summary
Disorder	MIM:

mRNA	NM_016769, 254675248
Protein	NP_058049, 254675249
Product	mothers against decapentaplegic homolog 3
RefSeq Status	VALIDATED

KEGG

mmu04310	Wnt signaling pathway
mmu04144	Endocytosis
mmu05200	Pathways in cancer
mmu05142	Chagas disease (American trypanosomiasis)
mmu04110	Cell cycle
mmu05212	Pancreatic cancer
mmu04520	Adherens junction
mmu05220	Chronic myeloid leukemia
mmu05210	Colorectal cancer
mmu04350	TGF-beta signaling pathway

WikiPathways

WP190	Cell cycle
WP113	TGF Beta Signaling Pathway
WP1763	PluriNetWork
WP572	EGFR1 Signaling Pathway
WP512	Id Signaling Pathway
WP265	Delta-Notch Signaling Pathway
WP488	Alpha6-Beta4 Integrin Signaling Pathway
WP447	Adipogenesis
WP539	Wnt Signaling Pathway NetPath
WP273	Ovarian Infertility Genes
WP252	Androgen Receptor Signaling Pathway
WP258	TGF-beta Receptor Signaling Pathway

Reactome

1210559

Signaling by TGF beta

Homo sapiens (human)	SMAD3	NP_005893.1
Pan troglodytes (chimpanzee)	SMAD3	XP_001159972.1
Canis lupus familiaris (dog)	SMAD3	XP_853566.1
Bos taurus (cattle)	SMAD3	XP_593090.2
Mus musculus (house mouse)	Smad3	NP_058049.2
Rattus norvegicus (Norway rat)	Smad3	NP_037227.1
Gallus gallus (chicken)	SMAD3	NP_989806.1
Danio rerio (zebrafish)	smad3b	NP_778258.1
Drosophila melanogaster (fruit fly)	Smox	NP_511079.1

Process

ID	Name	Evidence
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISO
GO:0001501	skeletal system development	IGI
GO:0001666	response to hypoxia	ISO
GO:0001701	in utero embryonic development	IGI
GO:0001707	mesoderm formation	IMP
GO:0001756	somitogenesis	IMP
GO:0001836	release of cytochrome c from mitochondria	ISO
GO:0001889	liver development	IGI
GO:0001933	negative regulation of protein phosphorylation	ISO
GO:0001947	heart looping	IGI
GO:0002076	osteoblast development	IGI
GO:0002520	immune system development	IGI
GO:0006351	transcription, DNA-dependent	ISO
GO:0006355	regulation of transcription, DNA-dependent	IEA
GO:0006366	transcription from RNA polymerase II promoter	TAS
GO:0006810	transport	ISO
GO:0006917	induction of apoptosis	ISO
GO:0006919	activation of caspase activity	ISO
GO:0006955	immune response	ISO
GO:0007050	cell cycle arrest	ISO
GO:0007179	transforming growth factor beta receptor signaling pathway	ISO
GO:0007179	transforming growth factor beta receptor signaling pathway	TAS
GO:0007183	SMAD protein complex assembly	ISO
GO:0007369	gastrulation	IGI
GO:0007492	endoderm development	IGI
GO:0008285	negative regulation of cell proliferation	ISO
GO:0008633	activation of pro-apoptotic gene products	ISO
GO:0008637	apoptotic mitochondrial changes	ISO
GO:0009880	embryonic pattern specification	IGI
GO:0010694	positive regulation of alkaline phosphatase activity	ISO
GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO
GO:0016202	regulation of striated muscle tissue development	IDA
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	IDA
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	ISO
GO:0019049	evasion of host defenses by virus	ISO
GO:0030308	negative regulation of cell growth	ISO
GO:0030335	positive regulation of cell migration	ISO
GO:0030501	positive regulation of bone mineralization	ISO
GO:0030878	thyroid gland development	IGI
GO:0032731	positive regulation of interleukin-1 beta production	ISO
GO:0032909	regulation of transforming growth factor-beta2 production	ISO
GO:0032916	positive regulation of transforming growth factor-beta3 production	ISO
GO:0035413	positive regulation of catenin import into nucleus	ISO
GO:0042110	T cell activation	IMP
GO:0042177	negative regulation of protein catabolic process	ISO
GO:0042993	positive regulation of transcription factor import into nucleus	ISO
GO:0043066	negative regulation of apoptosis	ISO
GO:0045216	cell-cell junction organization	ISO
GO:0045668	negative regulation of osteoblast differentiation	IGI
GO:0045893	positive regulation of transcription, DNA-dependent	IDA
GO:0045893	positive regulation of transcription, DNA-dependent	ISO
GO:0045930	negative regulation of mitotic cell cycle	ISO
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IGI
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	ISO
GO:0048340	paraxial mesoderm morphogenesis	IMP
GO:0048589	developmental growth	IGI
GO:0048617	embryonic foregut morphogenesis	IGI
GO:0048701	embryonic cranial skeleton morphogenesis	IGI
GO:0050678	regulation of epithelial cell proliferation	IMP
GO:0050776	regulation of immune response	IMP
GO:0050821	protein stabilization	ISO
GO:0050927	positive regulation of positive chemotaxis	ISO
GO:0051098	regulation of binding	IDA
GO:0051496	positive regulation of stress fiber assembly	ISO
GO:0051894	positive regulation of focal adhesion assembly	ISO
GO:0060039	pericardium development	IGI
GO:0060290	transdifferentiation	ISO
GO:0070306	lens fiber cell differentiation	IMP
GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	ISO

Component

ID	Name	Evidence
GO:0005622	intracellular	IEA
GO:0005634	nucleus	IDA
GO:0005634	nucleus	ISO
GO:0005637	nuclear inner membrane	ISO
GO:0005654	nucleoplasm	ISO
GO:0005667	transcription factor complex	ISO
GO:0005737	cytoplasm	ISO
GO:0005829	cytosol	ISO
GO:0005886	plasma membrane	IDA
GO:0043234	protein complex	ISO
GO:0043235	receptor complex	ISO

Function

ID	Name	Evidence
GO:0001102	RNA polymerase II activating transcription factor binding	ISO
GO:0003677	DNA binding	ISO
GO:0003690	double-stranded DNA binding	IDA
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA
GO:0003700	sequence-specific DNA binding transcription factor activity	ISO
GO:0003706	ligand-regulated transcription factor activity	ISO
GO:0005160	transforming growth factor beta receptor binding	ISO
GO:0005515	protein binding	IPI
GO:0005518	collagen binding	IPI
GO:0008013	beta-catenin binding	ISO
GO:0008134	transcription factor binding	IPI
GO:0008134	transcription factor binding	ISO
GO:0019901	protein kinase binding	ISO
GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	ISO
GO:0031625	ubiquitin protein ligase binding	ISO
GO:0042803	protein homodimerization activity	ISO
GO:0043565	sequence-specific DNA binding	ISO
GO:0046332	SMAD binding	ISO
GO:0046872	metal ion binding	IEA
GO:0070410	co-SMAD binding	ISO
GO:0070412	R-SMAD binding	ISO

GeneCards	Smad3
UniProt	B1B1A2, Q8BUN5
MGI	1201674
Ensembl	ENSMUSG00000032402

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RefSeq Accession	Definition	Sequence	Price	Select
NM_016769	Mus musculus MAD homolog 3 (Drosophila) (Smad3), mRNA.	Full Length	$2290.50
NM_016769	Mus musculus MAD homolog 3 (Drosophila) (Smad3), mRNA.	ORF Sequence	$370.62