• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Smad3 SMAD family member 3 [Mus musculus (house mouse)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OMu20270 NM_016769 Mus musculus SMAD family member 3 (Smad3), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OMu42549 XM_006510819 PREDICTED: Mus musculus SMAD family member 3 (Smad3), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OMu42550 XM_006510820 PREDICTED: Mus musculus SMAD family member 3 (Smad3), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OMu42551 XM_006510821 PREDICTED: Mus musculus SMAD family member 3 (Smad3), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OMu20270C NM_016769 Mus musculus SMAD family member 3 (Smad3), mRNA. Customized vector On-demand 7-9 $269.00
OMu42549C XM_006510819 PREDICTED: Mus musculus SMAD family member 3 (Smad3), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OMu42550C XM_006510820 PREDICTED: Mus musculus SMAD family member 3 (Smad3), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00
OMu42551C XM_006510821 PREDICTED: Mus musculus SMAD family member 3 (Smad3), transcript variant X3, mRNA. Customized vector On-demand 7-9 $209.00

*Business Day

Related Services

Gene Symbol Smad3
Entrez Gene ID 17127
Full Name SMAD family member 3
Synonyms AU022421, Madh3
General protein information
Preferred Names
mothers against decapentaplegic homolog 3
Names
mothers against decapentaplegic homolog 3
mad3
mMad3
Smad 3
MAD homolog 3
mothers against DPP homolog 3
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

9

9 D|9

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_016769, 254675248 NP_058049, 254675249 mothers against decapentaplegic homolog 3 ORF Sequence $550.00
XM_006510819, 568960760 XP_006510882, 568960761 mothers against decapentaplegic homolog 3 isoform X1 ORF Sequence $400.00
XM_006510820, 568960762 XP_006510883, 568960763 mothers against decapentaplegic homolog 3 isoform X2 ORF Sequence $400.00
XM_006510821, 568960764 XP_006510884, 568960765 mothers against decapentaplegic homolog 3 isoform X3 ORF Sequence $250.00
KEGG
mmu04310Wnt signaling pathway
mmu04520Adherens junction
mmu04110Cell cycle
mmu04350TGF-beta signaling pathway
mmu05220Chronic myeloid leukemia
mmu05212Pancreatic cancer
mmu05200Pathways in cancer
mmu05210Colorectal cancer
mmu04144Endocytosis
mmu05142Chagas disease (American trypanosomiasis)
mmu05166HTLV-I infection
mmu04390Hippo signaling pathway
mmu05321Inflammatory bowel disease (IBD)
mmu04068FoxO signaling pathway
WikiPathways
WP1763PluriNetWork
WP572EGFR1 Signaling Pathway
WP265Delta-Notch Signaling Pathway
WP447Adipogenesis
WP252Androgen Receptor Signaling Pathway
WP258TGF-beta Receptor Signaling Pathway
WP113TGF Beta Signaling Pathway
WP273Ovarian Infertility Genes
WP539Wnt Signaling Pathway NetPath
WP512Id Signaling Pathway
WP488Alpha6-Beta4 Integrin Signaling Pathway
WP190Cell cycle
WP2309XPodNet - protein-protein interactions in the podocyte expanded by STRING
WP2310PodNet: protein-protein interactions in the podocyte
LIPID MAPS
CellCycleCell cycle signaling pathway
Reactome
5605220Generic Transcription Pathway
5605225Downregulation of TGF-beta receptor signaling
5605224Downregulation of SMAD2/3:SMAD4 transcriptional activity
5605219Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
5604647Disease
5604774Signal Transduction
5604924Developmental Biology
5605206Signaling by TGF-beta Receptor Complex in Cancer
5605205Loss of Function of SMAD2/3 in Cancer
5605203Signaling by TGF-beta Receptor Complex
5605204SMAD2/3 Phosphorylation Motif Mutants in Cancer
5605202TGF-beta receptor signaling activates SMADs
5605212TGFBR2 Kinase Domain Mutants in Cancer
5605216Signaling by NODAL
5605218SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
5605211Loss of Function of TGFBR2 in Cancer
5605213TGFBR1 KD Mutants in Cancer
5605208Loss of Function of SMAD4 in Cancer
5605215TGFBR1 LBD Mutants in Cancer
5605217Signaling by Activin
5605207SMAD4 MH2 Domain Mutants in Cancer
5605214Loss of Function of TGFBR1 in Cancer
5604724Gene Expression
5605210TGFBR2 MSI Frameshift Mutants in Cancer
5605209SMAD2/3 MH2 Domain Mutants in Cancer
Homo sapiens (human)SMAD3NP_005893.1
Pan troglodytes (chimpanzee)SMAD3XP_001159972.2
Macaca mulatta (Rhesus monkey)SMAD3XP_001111262.1
Canis lupus familiaris (dog)SMAD3NP_001164300.1
Bos taurus (cattle)SMAD3NP_001192734.1
Mus musculus (house mouse)Smad3NP_058049.3
Rattus norvegicus (Norway rat)Smad3NP_037227.1
Gallus gallus (chicken)SMAD3NP_989806.1
Danio rerio (zebrafish)smad3bNP_778258.1
Drosophila melanogaster (fruit fly)SmoxNP_511079.1
Xenopus (Silurana) tropicalis (western clawed frog)smad3NP_001008436.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000122negative regulation of transcription from RNA polymerase II promoterISO
GO:0001501skeletal system developmentIGI
GO:0001649osteoblast differentiationIMP
GO:0001666response to hypoxiaISO
GO:0001701in utero embryonic developmentIGI
GO:0001707mesoderm formationIMP
GO:0001756somitogenesisIMP
GO:0001889liver developmentIGI
GO:0001933negative regulation of protein phosphorylationISO
GO:0001947heart loopingIGI
GO:0002076osteoblast developmentIGI
GO:0002520immune system developmentIGI
GO:0006351transcription, DNA-templatedIEA
GO:0006355regulation of transcription, DNA-templatedIEA
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0006810transportISO
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processISO
GO:0006955immune responseISO
GO:0007050cell cycle arrestISO
GO:0007179transforming growth factor beta receptor signaling pathwayIDA
GO:0007179transforming growth factor beta receptor signaling pathwayISO
GO:0007183SMAD protein complex assemblyISO
GO:0007369gastrulationIGI
GO:0007492endoderm developmentIGI
GO:0008285negative regulation of cell proliferationISO
GO:0009880embryonic pattern specificationIGI
GO:0010694positive regulation of alkaline phosphatase activityISO
GO:0010718positive regulation of epithelial to mesenchymal transitionISO
GO:0016202regulation of striated muscle tissue developmentIDA
GO:0017015regulation of transforming growth factor beta receptor signaling pathwayIDA
GO:0017015regulation of transforming growth factor beta receptor signaling pathwayISO
GO:0019049evasion or tolerance of host defenses by virusISO
GO:0023019signal transduction involved in regulation of gene expressionISO
GO:0030308negative regulation of cell growthISO
GO:0030335positive regulation of cell migrationISO
GO:0030501positive regulation of bone mineralizationISO
GO:0030878thyroid gland developmentIGI
GO:0032332positive regulation of chondrocyte differentiationIMP
GO:0032731positive regulation of interleukin-1 beta productionISO
GO:0032909regulation of transforming growth factor beta2 productionISO
GO:0032916positive regulation of transforming growth factor beta3 productionISO
GO:0032924activin receptor signaling pathwayISO
GO:0033689negative regulation of osteoblast proliferationIMP
GO:0035413positive regulation of catenin import into nucleusISO
GO:0035556intracellular signal transductionISO
GO:0038092nodal signaling pathwayISO
GO:0042110T cell activationIMP
GO:0042177negative regulation of protein catabolic processISO
GO:0042993positive regulation of transcription factor import into nucleusISO
GO:0043066negative regulation of apoptotic processISO
GO:0045216cell-cell junction organizationISO
GO:0045668negative regulation of osteoblast differentiationIGI
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedISO
GO:0045930negative regulation of mitotic cell cycleISO
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIGI
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0048340paraxial mesoderm morphogenesisIMP
GO:0048589developmental growthIGI
GO:0048617embryonic foregut morphogenesisIGI
GO:0048701embryonic cranial skeleton morphogenesisIGI
GO:0050678regulation of epithelial cell proliferationIMP
GO:0050728negative regulation of inflammatory responseIMP
GO:0050776regulation of immune responseIMP
GO:0050821protein stabilizationISO
GO:0050927positive regulation of positive chemotaxisISO
GO:0051098regulation of bindingIDA
GO:0051496positive regulation of stress fiber assemblyISO
GO:0051894positive regulation of focal adhesion assemblyISO
GO:0060039pericardium developmentIGI
GO:0060290transdifferentiationISO
GO:0061045negative regulation of wound healingIMP
GO:0070306lens fiber cell differentiationIMP
GO:0090263positive regulation of canonical Wnt signaling pathwayISO
GO:0097191extrinsic apoptotic signaling pathwayISO
GO:0097296activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayISO
GO:1901313positive regulation of gene expression involved in extracellular matrix organizationISO
Component
IDNameEvidence
GO:0000790nuclear chromatinISO
GO:0005622intracellularIEA
GO:0005634nucleusIDA
GO:0005634nucleusISO
GO:0005637nuclear inner membraneISO
GO:0005667transcription factor complexISO
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISO
GO:0005886plasma membraneIDA
GO:0043234protein complexISO
GO:0043235receptor complexISO
GO:0071141SMAD protein complexISO
GO:0071144SMAD2-SMAD3 protein complexISO
Function
IDNameEvidence
GO:0000987core promoter proximal region sequence-specific DNA bindingISO
GO:0000988protein binding transcription factor activityISO
GO:0001102RNA polymerase II activating transcription factor bindingISO
GO:0003677DNA bindingISO
GO:0003682chromatin bindingIDA
GO:0003690double-stranded DNA bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003700sequence-specific DNA binding transcription factor activityISO
GO:0003700sequence-specific DNA binding transcription factor activityISO
GO:0005160transforming growth factor beta receptor bindingISO
GO:0005515protein bindingIPI
GO:0005518collagen bindingIPI
GO:0008013beta-catenin bindingISO
GO:0008134transcription factor bindingIPI
GO:0008134transcription factor bindingISO
GO:0008270zinc ion bindingISO
GO:0019899enzyme bindingISO
GO:0019901protein kinase bindingISO
GO:0019902phosphatase bindingISO
GO:0030618transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityISO
GO:0031490chromatin DNA bindingIDA
GO:0031625ubiquitin protein ligase bindingISO
GO:0042803protein homodimerization activityISO
GO:0043130ubiquitin bindingISO
GO:0043425bHLH transcription factor bindingISO
GO:0043565sequence-specific DNA bindingISO
GO:0044212transcription regulatory region DNA bindingISO
GO:0046332SMAD bindingISO
GO:0046872metal ion bindingIEA
GO:0070410co-SMAD bindingISO
GO:0070412R-SMAD bindingISO
GeneCards Smad3
UniProt Q8BUN5
MGI 1201674
Vega OTTMUSG00000021500
Ensembl ENSMUSG00000032402

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.