PTCRA pre T-cell antigen receptor alpha [Homo sapiens (human)]
| Gene Symbol | PTCRA |
| Entrez Gene ID | 171558 |
| Full Name | pre T-cell antigen receptor alpha |
| Synonyms | PT-ALPHA, PTA |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
6 6p21.3 |
| Summary | In immature T cells the T-cell receptor beta-chain gene (TCRB; MIM 186930) is rearranged and expressed before the TCRA (MIM 186880) chain. At this early stage, TCRB can associate with the pre-T-cell receptor alpha chain (PTCRA). The PTCRA, together with TCRB and the CD3 complex (see MIM 186740), minimally make up the pre-T cell receptor (pre-TCR), which regulates early T cell development.[supplied by OMIM]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 606817 |
| mRNA | NM_138296, 110227623 |
| Protein | NP_612153, 110227624 |
| Product | pre T-cell antigen receptor alpha precursor |
| RefSeq Status | VALIDATED |
| hsa04330 | Notch signaling pathway |
Pathway Interaction Database
| cmyb_pathway | C-MYB transcription factor network |
| notch_pathway | Notch signaling pathway |
| Homo sapiens (human) | PTCRA | NP_612153.2 |
| Pan troglodytes (chimpanzee) | LOC462701 | XP_518479.2 |
| Canis lupus familiaris (dog) | LOC481804 | XP_538925.2 |
| Bos taurus (cattle) | PTCRA | NP_001069101.1 |
| Mus musculus (house mouse) | Ptcra | NP_035325.1 |
| Rattus norvegicus (Norway rat) | Ptcra | XP_001062619.1 |
| ID | Name | Evidence |
| GO:0070244 | negative regulation of thymocyte apoptosis | IEA |
Component
| ID | Name | Evidence |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0004872 | receptor activity | IEA |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |