• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Mus musculus (house mouse)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_008576 Mus musculus ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1), mRNA. GenEZ ORF Cloning In-stock $1598.00 $1549.00 22
XM_006521839 PREDICTED: Mus musculus ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006521840 PREDICTED: Mus musculus ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006521841 PREDICTED: Mus musculus ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006521842 PREDICTED: Mus musculus ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

*Business Day

Related Services

Gene Symbol Abcc1
Entrez Gene ID 17250
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Synonyms Abcc1a, Abcc1b, MRP, Mdrap, Mrp1
General protein information
Preferred Names
multidrug resistance-associated protein 1
Names
multidrug resistance-associated protein 1
LTC4 transporter
leukotriene C(4) transporter
multiple drug resistance-associated protein
ATP-binding cassette, sub-family C (CFTR/MRP), member 1a
ATP-binding cassette, sub-family C (CFTR/MRP), member 1b
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

16

16 A1|16

Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011].
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_008576, 357430786 NP_032602, 6678848 multidrug resistance-associated protein 1 ORF Sequence $1399.00
XM_006521839, 568994719 XP_006521902, 568994720 multidrug resistance-associated protein 1 isoform X1 ORF Sequence $2500.00
XM_006521840, 568994721 XP_006521903, 568994722 multidrug resistance-associated protein 1 isoform X2 ORF Sequence $1500.00
XM_006521841, 568994723 XP_006521904, 568994724 multidrug resistance-associated protein 1 isoform X3 ORF Sequence $1500.00
XM_006521842, 568994725 XP_006521905, 568994726 multidrug resistance-associated protein 1 isoform X4 ORF Sequence $1500.00
KEGG
mmu02010ABC transporters
mmu04977Vitamin digestion and absorption
mmu05206MicroRNAs in cancer
WikiPathways
WP475Irinotecan Pathway
Reactome
5605453Synthesis of Leukotrienes (LT) and Eoxins (EX)
5604687Defective TCN2 causes hereditary megaloblastic anemia
5604688Defects in cobalamin (B12) metabolism
5604686Metabolism of vitamins and cofactors
5604644Metabolism
5604683Metabolism of lipids and lipoproteins
5604647Disease
5604697Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
5604696Defective MMAB causes methylmalonic aciduria type cblB
5604690Defective GIF causes intrinsic factor deficiency
5604685Metabolism of water-soluble vitamins and cofactors
5604684Cobalamin (Cbl, vitamin B12) transport and metabolism
5604691Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
5604689Defects in vitamin and cofactor metabolism
5604693Defective CUBN causes hereditary megaloblastic anemia 1
5604692Defective AMN causes hereditary megaloblastic anemia 1
5604695Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
5604885Arachidonic acid metabolism
5604694Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
5604659Transmembrane transport of small molecules
5604701Defective CD320 causes methylmalonic aciduria
5605469ABC-family proteins mediated transport
5604704Defective HLCS causes multiple carboxylase deficiency
5604700Defective MUT causes methylmalonic aciduria mut type
5604703Defects in biotin (Btn) metabolism
5604699Defective MMAA causes methylmalonic aciduria type cblA
5604702Defective BTD causes biotidinase deficiency
5604698Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Homo sapiens (human)ABCC1NP_004987.2
Pan troglodytes (chimpanzee)ABCC1XP_001145351.1
Canis lupus familiaris (dog)ABCC1NP_001002971.1
Bos taurus (cattle)ABCC1NP_776648.1
Mus musculus (house mouse)Abcc1NP_032602.1
Rattus norvegicus (Norway rat)Abcc1NP_071617.2
Gallus gallus (chicken)ABCC1NP_001012540.1
Danio rerio (zebrafish)abcc1XP_001341895.3
Caenorhabditis elegansmrp-1NP_001033553.1
Caenorhabditis elegansmrp-2NP_508121.1
Arabidopsis thaliana (thale cress)MRP5NP_171908.1
Process
IDNameEvidence
GO:0006200ATP catabolic processISO
GO:0006810transportIEA
GO:0006855drug transmembrane transportISO
GO:0006979response to oxidative stressISO
GO:0015911plasma membrane long-chain fatty acid transportISO
GO:0030335positive regulation of cell migrationISO
GO:0033700phospholipid effluxISO
GO:0034775glutathione transmembrane transportISO
GO:0042493response to drugISO
GO:0042908xenobiotic transportISO
GO:0043215daunorubicin transportISO
GO:0046618drug exportISO
GO:0055085transmembrane transportISO
GO:0060326cell chemotaxisISO
GO:1901215negative regulation of neuron deathISO
Component
IDNameEvidence
GO:0005737cytoplasmISO
GO:0005886plasma membraneISO
GO:0005887integral component of plasma membraneIDA
GO:0005887integral component of plasma membraneISO
GO:0016020membraneISO
GO:0016021integral component of membraneIEA
GO:0016323basolateral plasma membraneISO
GO:0070062extracellular vesicular exosomeISO
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0005215transporter activityIEA
GO:0005324long-chain fatty acid transporter activityISO
GO:0005524ATP bindingIEA
GO:0008559xenobiotic-transporting ATPase activityISO
GO:0015238drug transmembrane transporter activityISO
GO:0015431glutathione S-conjugate-exporting ATPase activityISO
GO:0015562efflux transmembrane transporter activityISO
GO:0016787hydrolase activityIEA
GO:0016887ATPase activityISO
GO:0017111nucleoside-triphosphatase activityIEA
GO:0034040lipid-transporting ATPase activityISO
GO:0034634glutathione transmembrane transporter activityISO
GO:0042626ATPase activity, coupled to transmembrane movement of substancesIEA
GO:0046624sphingolipid transporter activityISO
GeneCards Abcc1
UniProt O35379, A5D6P3
MGI 102676
Vega OTTMUSG00000027051
Ensembl ENSMUSG00000023088

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.