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Myc myelocytomatosis oncogene [Mus musculus (house mouse)]


RefSeq Accession Definition Sequence Price Select
NM_010849 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 1, mRNA. Full Length $695.71
ORF Sequence $395.85
NM_001177352 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 1, mRNA. Full Length $695.71
ORF Sequence $382.80
NM_001177353 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 2, mRNA. Full Length $694.84
ORF Sequence $394.98
NM_001177354 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 2, mRNA. Full Length $694.84
ORF Sequence $382.80


Gene Symbol Myc
Entrez Gene ID 17869
Full Name myelocytomatosis oncogene
Synonyms AU016757, Myc2, Niard, Nird, bHLHe39
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

15

15 D2-D3|15 32.0 cM
Summary The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
Disorder

MIM:

mRNA NM_010849, 100913213
Protein NP_034979, 71834865
Product myc proto-oncogene protein isoform a
RefSeq Status REVIEWED
mRNA NM_001177352, 293629263
Protein NP_001170823, 293629264
Product myc proto-oncogene protein isoform b
RefSeq Status REVIEWED
mRNA NM_001177353, 293629266
Protein NP_001170824, 293629267
Product myc proto-oncogene protein isoform c
RefSeq Status REVIEWED
mRNA NM_001177354, 293629269
Protein NP_001170825, 293629270
Product myc proto-oncogene protein isoform b
RefSeq Status REVIEWED
KEGG
mmu05220Chronic myeloid leukemia
mmu05210Colorectal cancer
mmu04350TGF-beta signaling pathway
mmu05222Small cell lung cancer
mmu04310Wnt signaling pathway
mmu05219Bladder cancer
mmu05221Acute myeloid leukemia
mmu05216Thyroid cancer
mmu04012ErbB signaling pathway
mmu04110Cell cycle
mmu05200Pathways in cancer
mmu04630Jak-STAT signaling pathway
mmu05213Endometrial cancer
mmu04010MAPK signaling pathway
WikiPathways
WP1254Apoptosis
WP413G1 to S cell cycle control
WP339ESC Pluripotency Pathways
WP1763PluriNetWork
WP350p38 MAPK Signaling Pathway (BioCarta)
WP572EGFR1 Signaling Pathway
WP493MAPK signaling pathway
WP723Wnt Signaling Pathway and Pluripotency
WP403Wnt Signaling Pathway
WP258TGF-beta Receptor Signaling Pathway
WP1261ErbB signaling pathway
Reactome
1210566Cyclin A:Cdk2-associated events at S phase entry
1210048G1/S Transition
1210038Cell Cycle, Mitotic
1210049Mitotic G1-G1/S phases
1210060Cyclin E associated events during G1/S transition
1210046S Phase
Homo sapiens (human)MYCNP_002458.2
Pan troglodytes (chimpanzee)MYCXP_519958.2
Canis lupus familiaris (dog)MYCNP_001003246.1
Bos taurus (cattle)MYCNP_001039539.1
Mus musculus (house mouse)MycNP_034979.3
Rattus norvegicus (Norway rat)MycNP_036735.2
Gallus gallus (chicken)MYCNP_001026123.1
Danio rerio (zebrafish)mycaNP_571487.2
Danio rerio (zebrafish)mycbNP_956466.1
Process
IDNameEvidence
GO:0001658branching involved in ureteric bud morphogenesisIMP
GO:0001783B cell apoptosisIMP
GO:0001836release of cytochrome c from mitochondriaIDA
GO:0002053positive regulation of mesenchymal cell proliferationIMP
GO:0002904positive regulation of B cell apoptosisIGI
GO:0006006glucose metabolic processISO
GO:0006309DNA fragmentation involved in apoptotic nuclear changeIDA
GO:0006351transcription, DNA-dependentISO
GO:0006352transcription initiation, DNA-dependentISO
GO:0006355regulation of transcription, DNA-dependentIGI
GO:0006355regulation of transcription, DNA-dependentISO
GO:0006366transcription from RNA polymerase II promoterISO
GO:0006919activation of caspase activityIDA
GO:0007346regulation of mitotic cell cycleISO
GO:0008284positive regulation of cell proliferationIDA
GO:0008284positive regulation of cell proliferationIGI
GO:0008284positive regulation of cell proliferationISO
GO:0008629induction of apoptosis by intracellular signalsIDA
GO:0008629induction of apoptosis by intracellular signalsIMP
GO:0008633activation of pro-apoptotic gene productsIDA
GO:0008633activation of pro-apoptotic gene productsIMP
GO:0008634negative regulation of survival gene product expressionIDA
GO:0008634negative regulation of survival gene product expressionIMP
GO:0009314response to radiationIDA
GO:0009314response to radiationIMP
GO:0010468regulation of gene expressionIDA
GO:0016055Wnt receptor signaling pathwayIDA
GO:0016485protein processingIMP
GO:0032091negative regulation of protein bindingIDA
GO:0032204regulation of telomere maintenanceISO
GO:0042474middle ear morphogenesisIMP
GO:0042981regulation of apoptosisIDA
GO:0043085positive regulation of catalytic activityIMP
GO:0043279response to alkaloidIMP
GO:0043473pigmentationIMP
GO:0045893positive regulation of transcription, DNA-dependentISO
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0048705skeletal system morphogenesisIMP
GO:0050910detection of mechanical stimulus involved in sensory perception of soundIMP
GO:0071445cellular response to protein stimulusIDA
GO:0090096positive regulation of metanephric cap mesenchymal cell proliferationIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005634nucleusISO
GO:0005654nucleoplasmISO
GO:0005730nucleolusISO
GO:0005737cytoplasmISO
GO:0005819spindleIDA
GO:0016604nuclear bodyIDA
GO:0030424axonIDA
Function
IDNameEvidence
GO:0003677DNA bindingIDA
GO:0003677DNA bindingISO
GO:0003690double-stranded DNA bindingISO
GO:0003700sequence-specific DNA binding transcription factor activityISO
GO:0005515protein bindingIPI
GO:0043565sequence-specific DNA bindingISO
GO:0046982protein heterodimerization activityISO
GO:0070888E-box bindingISO
GeneCards Myc
UniProt B2RSN1, P01108
MGI 97250
Ensembl ENSMUSG00000022346

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