• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Myc myelocytomatosis oncogene [Mus musculus (house mouse)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001177352 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001177353 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001177354 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_010849 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

*Business Day

Related Services

Gene Symbol Myc
Entrez Gene ID 17869
Full Name myelocytomatosis oncogene
Synonyms AU016757, Myc2, Niard, Nird, bHLHe39
General protein information
Preferred Names
myc proto-oncogene protein
Names
myc proto-oncogene protein
c-myc proto-oncogene
transcription factor p64
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

15

15 D2-D3|15 26.19 cM

Summary The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_001177352, 293629263 NP_001170823, 293629264 myc proto-oncogene protein isoform b ORF Sequence $360.00
NM_001177353, 293629266 NP_001170824, 293629267 myc proto-oncogene protein isoform c ORF Sequence $550.00
NM_001177354, 293629269 NP_001170825, 293629270 myc proto-oncogene protein isoform b ORF Sequence $360.00
NM_010849, 100913213 NP_034979, 71834865 myc proto-oncogene protein isoform a ORF Sequence $360.00
KEGG
mmu04010MAPK signaling pathway
mmu04310Wnt signaling pathway
mmu04012ErbB signaling pathway
mmu04110Cell cycle
mmu04350TGF-beta signaling pathway
mmu05219Bladder cancer
mmu05220Chronic myeloid leukemia
mmu05222Small cell lung cancer
mmu05213Endometrial cancer
mmu04630Jak-STAT signaling pathway
mmu05200Pathways in cancer
mmu05216Thyroid cancer
mmu05210Colorectal cancer
mmu05221Acute myeloid leukemia
mmu05166HTLV-I infection
mmu04151PI3K-Akt signaling pathway
mmu05161Hepatitis B
mmu04390Hippo signaling pathway
mmu05202Transcriptional misregulation in cancer
mmu05205Proteoglycans in cancer
mmu05169Epstein-Barr virus infection
mmu05206MicroRNAs in cancer
mmu04919Thyroid hormone signaling pathway
WikiPathways
WP1763PluriNetWork
WP572EGFR1 Signaling Pathway
WP403Wnt Signaling Pathway
WP1254Apoptosis
WP493MAPK signaling pathway
WP258TGF-beta Receptor Signaling Pathway
WP350p38 MAPK Signaling Pathway (BioCarta)
WP339ESC Pluripotency Pathways
WP413G1 to S cell cycle control
WP1261ErbB signaling pathway
WP723Wnt Signaling Pathway and Pluripotency
LIPID MAPS
CellCycleCell cycle signaling pathway
Reactome
5604598Cell Cycle, Mitotic
5604599Cell Cycle
5604610G1/S Transition
5604608S Phase
5605230Cyclin A:Cdk2-associated events at S phase entry
5604611Mitotic G1-G1/S phases
5604622Cyclin E associated events during G1/S transition
Homo sapiens (human)MYCNP_002458.2
Pan troglodytes (chimpanzee)MYCNP_001136266.1
Macaca mulatta (Rhesus monkey)MYCNP_001136345.1
Canis lupus familiaris (dog)MYCNP_001003246.2
Bos taurus (cattle)MYCNP_001039539.1
Mus musculus (house mouse)MycNP_034979.3
Rattus norvegicus (Norway rat)MycNP_036735.2
Gallus gallus (chicken)MYCNP_001026123.1
Danio rerio (zebrafish)mycaNP_571487.2
Danio rerio (zebrafish)mycbNP_956466.1
Xenopus (Silurana) tropicalis (western clawed frog)MGC76254NP_989390.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000122negative regulation of transcription from RNA polymerase II promoterISO
GO:0000165MAPK cascadeISO
GO:0001658branching involved in ureteric bud morphogenesisIMP
GO:0001783B cell apoptotic processIMP
GO:0002053positive regulation of mesenchymal cell proliferationIMP
GO:0002082regulation of oxidative phosphorylationISO
GO:0002904positive regulation of B cell apoptotic processIGI
GO:0006006glucose metabolic processISO
GO:0006338chromatin remodelingISO
GO:0006351transcription, DNA-templatedISO
GO:0006352DNA-templated transcription, initiationISO
GO:0006355regulation of transcription, DNA-templatedIGI
GO:0006355regulation of transcription, DNA-templatedISO
GO:0006366transcription from RNA polymerase II promoterISO
GO:0006848pyruvate transportISO
GO:0006865amino acid transportISO
GO:0006879cellular iron ion homeostasisISO
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIDA
GO:0006974cellular response to DNA damage stimulusIDA
GO:0006974cellular response to DNA damage stimulusISO
GO:0007007inner mitochondrial membrane organizationISO
GO:0007050cell cycle arrestISO
GO:0007346regulation of mitotic cell cycleISO
GO:0008283cell proliferationISO
GO:0008284positive regulation of cell proliferationIDA
GO:0008284positive regulation of cell proliferationIGI
GO:0008284positive regulation of cell proliferationISO
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damageIDA
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damageIMP
GO:0009314response to radiationIDA
GO:0009314response to radiationIMP
GO:0010332response to gamma radiationISO
GO:0010468regulation of gene expressionIDA
GO:0010468regulation of gene expressionISO
GO:0010629negative regulation of gene expressionISO
GO:0010918positive regulation of mitochondrial membrane potentialISO
GO:0016055Wnt signaling pathwayIDA
GO:0016485protein processingIMP
GO:0019087transformation of host cell by virusISO
GO:0032091negative regulation of protein bindingIDA
GO:0032204regulation of telomere maintenanceISO
GO:0035690cellular response to drugIDA
GO:0035690cellular response to drugISO
GO:0035914skeletal muscle cell differentiationIMP
GO:0042474middle ear morphogenesisIMP
GO:0042981regulation of apoptotic processIDA
GO:0043085positive regulation of catalytic activityIMP
GO:0043279response to alkaloidIMP
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic processISO
GO:0043473pigmentationIMP
GO:0044330canonical Wnt signaling pathway involved in positive regulation of wound healingISO
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic processIGI
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic processIGI
GO:0045656negative regulation of monocyte differentiationISO
GO:0045787positive regulation of cell cycleISO
GO:0045821positive regulation of glycolytic processISO
GO:0045893positive regulation of transcription, DNA-templatedISO
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0046325negative regulation of glucose importISO
GO:0046722lactic acid secretionISO
GO:0048146positive regulation of fibroblast proliferationISO
GO:0048147negative regulation of fibroblast proliferationISO
GO:0048705skeletal system morphogenesisIMP
GO:0050679positive regulation of epithelial cell proliferationISO
GO:0050910detection of mechanical stimulus involved in sensory perception of soundIMP
GO:0051276chromosome organizationISO
GO:0051782negative regulation of cell divisionISO
GO:0060070canonical Wnt signaling pathwayISO
GO:0060548negative regulation of cell deathISO
GO:0090096positive regulation of metanephric cap mesenchymal cell proliferationIMP
GO:1901857positive regulation of cellular respirationISO
GO:2000573positive regulation of DNA biosynthetic processISO
GO:2001022positive regulation of response to DNA damage stimulusISO
GO:2001171positive regulation of ATP biosynthetic processISO
GO:2001235positive regulation of apoptotic signaling pathwayIDA
GO:2001235positive regulation of apoptotic signaling pathwayIMP
Component
IDNameEvidence
GO:0005622intracellularIMP
GO:0005634nucleusIDA
GO:0005634nucleusISO
GO:0005654nucleoplasmISO
GO:0005730nucleolusISO
GO:0005737cytoplasmISO
GO:0005739mitochondrionISO
GO:0005819spindleIDA
GO:0016604nuclear bodyIDA
GO:0030424axonIDA
GO:0043234protein complexISO
Function
IDNameEvidence
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingISO
GO:0000987core promoter proximal region sequence-specific DNA bindingIDA
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISO
GO:0003677DNA bindingIDA
GO:0003677DNA bindingISO
GO:0003690double-stranded DNA bindingISO
GO:0003700sequence-specific DNA binding transcription factor activityISO
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingISO
GO:0032403protein complex bindingISO
GO:0043565sequence-specific DNA bindingISO
GO:0046982protein heterodimerization activityISO
GO:0046983protein dimerization activityIEA
GO:0070491repressing transcription factor bindingISO
GO:0070888E-box bindingISO
GeneCards Myc
UniProt B2RSN1, P01108
MGI 97250
Vega OTTMUSG00000034892
Ensembl ENSMUSG00000022346

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.