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Myc myelocytomatosis oncogene [Mus musculus (house mouse)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001177352 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001177353 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001177354 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_010849 Mus musculus myelocytomatosis oncogene (Myc), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Related Services

Gene Symbol Myc
Entrez Gene ID 17869
Full Name myelocytomatosis oncogene
Synonyms AU016757, Myc2, Niard, Nird, bHLHe39
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

15

15 D2-D3|15 32.0 cM

Summary The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_001177352, 293629263 NP_001170823, 293629264 myc proto-oncogene protein isoform b ORF Sequence $360.00
NM_001177353, 293629266 NP_001170824, 293629267 myc proto-oncogene protein isoform c ORF Sequence $550.00
NM_001177354, 293629269 NP_001170825, 293629270 myc proto-oncogene protein isoform b ORF Sequence $360.00
NM_010849, 100913213 NP_034979, 71834865 myc proto-oncogene protein isoform a ORF Sequence $360.00
KEGG
mmu05200Pathways in cancer
mmu05169Epstein-Barr virus infection
mmu05220Chronic myeloid leukemia
mmu04151PI3K-Akt signaling pathway
mmu05202Transcriptional misregulation in cancer
mmu04630Jak-STAT signaling pathway
mmu05210Colorectal cancer
mmu05213Endometrial cancer
mmu04010MAPK signaling pathway
mmu05166HTLV-I infection
mmu04310Wnt signaling pathway
mmu04350TGF-beta signaling pathway
mmu05219Bladder cancer
mmu05222Small cell lung cancer
mmu05216Thyroid cancer
mmu05221Acute myeloid leukemia
mmu04012ErbB signaling pathway
mmu05161Hepatitis B
mmu04110Cell cycle
WikiPathways
WP258TGF-beta Receptor Signaling Pathway
WP403Wnt Signaling Pathway
WP1261ErbB signaling pathway
WP1254Apoptosis
WP339ESC Pluripotency Pathways
WP413G1 to S cell cycle control
WP350p38 MAPK Signaling Pathway (BioCarta)
WP1763PluriNetWork
WP572EGFR1 Signaling Pathway
WP493MAPK signaling pathway
WP723Wnt Signaling Pathway and Pluripotency
LIPID MAPS
CellCycleCell cycle signaling pathway
Reactome
2675847Cell Cycle, Mitotic
2676289Signaling by NOTCH
2675848Cell Cycle
2676288Signaling by NOTCH1
2677025NOTCH1 Intracellular Domain Regulates Transcription
2675859Mitotic G1-G1/S phases
2675870Cyclin E associated events during G1/S transition
2675856S Phase
2675999Signal Transduction
2675858G1/S Transition
2676405Cyclin A:Cdk2-associated events at S phase entry
Homo sapiens (human)MYCNP_002458.2
Pan troglodytes (chimpanzee)MYCNP_001136266.1
Macaca mulatta (Rhesus monkey)MYCNP_001136345.1
Canis lupus familiaris (dog)MYCNP_001003246.2
Bos taurus (cattle)MYCNP_001039539.1
Mus musculus (house mouse)MycNP_034979.3
Rattus norvegicus (Norway rat)MycNP_036735.2
Gallus gallus (chicken)MYCNP_001026123.1
Danio rerio (zebrafish)mycaNP_571487.2
Danio rerio (zebrafish)mycbNP_956466.1
GeneCards Myc
UniProt B2RSN1, P01108
MGI 97250
Ensembl ENSMUSG00000022346

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General protein information

Preferred Names
myc proto-oncogene protein
Names
myc proto-oncogene protein
c-myc proto-oncogene
transcription factor p64

Interactant



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