• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


AGXT alanine-glyoxylate aminotransferase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000030 Homo sapiens alanine-glyoxylate aminotransferase (AGXT), mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

Related Services

Gene Symbol AGXT
Entrez Gene ID 189
Full Name alanine-glyoxylate aminotransferase
Synonyms AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q37.3

Summary This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604285

Hyperoxaluria, primary, type 1, 259900 (3)

mRNA Protein Product Sequence Price Select
NM_000030, 171906613 NP_000021, 4557289 serine--pyruvate aminotransferase ORF Sequence $400.00
KEGG
hsa00260Glycine, serine and threonine metabolism
hsa00630Glyoxylate and dicarboxylate metabolism
hsa00250Alanine, aspartate and glutamate metabolism
hsa04146Peroxisome
hsa01200Carbon metabolism
WikiPathways
WP106Alanine and aspartate metabolism
BIOCYC
HUMAN_GLYSYN-ALA-PWYglycine biosynthesis III
Reactome
REACT_13Metabolism of amino acids and derivatives
REACT_16925Glyoxylate metabolism
REACT_111217Metabolism
Homo sapiens (human)AGXTNP_000021.1
Pan troglodytes (chimpanzee)AGXTXP_003309627.2
Macaca mulatta (Rhesus monkey)AGXTXP_001090301.2
Canis lupus familiaris (dog)LOC100855679XP_003639939.1
Canis lupus familiaris (dog)LOC607355XP_848328.2
Bos taurus (cattle)AGXTNP_001095825.1
Mus musculus (house mouse)AgxtNP_057911.2
Rattus norvegicus (Norway rat)AgxtNP_085914.2
Gallus gallus (chicken)AGXTXP_003641783.2
Danio rerio (zebrafish)agxtaNP_001002331.1
Danio rerio (zebrafish)agxtbNP_998327.1
Drosophila melanogaster (fruit fly)SpatNP_511062.1
Caenorhabditis elegansT14D7.1NP_495885.1
Arabidopsis thaliana (thale cress)AGTNP_178969.1
Xenopus (Silurana) tropicalis (western clawed frog)agxtNP_001006705.1
Process
IDNameEvidence
GO:0006625protein targeting to peroxisomeIMP
GO:0009436glyoxylate catabolic processIDA
GO:0019265glycine biosynthetic process, by transamination of glyoxylateIDA
GO:0019448L-cysteine catabolic processIDA
GO:0034641cellular nitrogen compound metabolic processTAS
GO:0042853L-alanine catabolic processIDA
GO:0042866pyruvate biosynthetic processIEA
GO:0044281small molecule metabolic processTAS
GO:0046487glyoxylate metabolic processIMP
GO:0046487glyoxylate metabolic processTAS
GO:0046724oxalic acid secretionIEA
GO:0051384response to glucocorticoidIEA
GO:0051591response to cAMPIEA
Component
IDNameEvidence
GO:0005759mitochondrial matrixIEA
GO:0005777peroxisomeIDA
GO:0005782peroxisomal matrixIDA
GO:0005782peroxisomal matrixTAS
Function
IDNameEvidence
GO:0004760serine-pyruvate transaminase activityIEA
GO:0005102receptor bindingIPI
GO:0005515protein bindingIPI
GO:0008453alanine-glyoxylate transaminase activityIDA
GO:0008453alanine-glyoxylate transaminase activityTAS
GO:0008483transaminase activityIDA
GO:0016597amino acid bindingIDA
GO:0030170pyridoxal phosphate bindingIDA
GO:0030170pyridoxal phosphate bindingIMP
GO:0042803protein homodimerization activityIDA
GeneCards AGXT
PDB 1H0C, 2YOB, 4I8A, 3R9A, 1J04
UniProt P21549
Vega OTTHUMG00000133354
MIM 604285
Ensembl ENSG00000172482
HGNC 341
HPRD 05048

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the AGXT gene?

The AGXT gene provides instructions for making a liver enzyme called alanine-glyoxylate aminotransferase. Inside liver cells, this enzyme is found in peroxisomes, structures that are important for several cellular activities such as ridding the cell of toxic substances and helping to break down certain fats. Peroxisomes contain several enzymes that are imported from the internal fluid of the cell (cytosol). Enzymes that are transferred into peroxisomes have a special arrangement of building blocks (amino acids) at one end of the enzyme that serves as a shipping address. In the peroxisome, alanine-glyoxylate aminotransferase converts a compound called glyoxylate to the amino acid glycine, which is later used for making enzymes and other proteins.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.