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AGXT alanine-glyoxylate aminotransferase [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18906 NM_000030 Homo sapiens alanine-glyoxylate aminotransferase (AGXT), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu18906C NM_000030 Homo sapiens alanine-glyoxylate aminotransferase (AGXT), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol AGXT
Entrez Gene ID 189
Full Name alanine-glyoxylate aminotransferase
Synonyms AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q37.3

Summary This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604285

Hyperoxaluria, primary, type 1, 259900 (3)

mRNA Protein Product Sequence Price Select
NM_000030, 171906613 NP_000021, 4557289 serine--pyruvate aminotransferase ORF Sequence $400.00
KEGG
hsa00260Glycine, serine and threonine metabolism
hsa00630Glyoxylate and dicarboxylate metabolism
hsa00250Alanine, aspartate and glutamate metabolism
hsa04146Peroxisome
hsa01200Carbon metabolism
WikiPathways
WP106Alanine and aspartate metabolism
BIOCYC
HUMAN_GLYSYN-ALA-PWYglycine biosynthesis III
Reactome
REACT_13Metabolism of amino acids and derivatives
REACT_16925Glyoxylate metabolism
REACT_111217Metabolism
Homo sapiens (human)AGXTNP_000021.1
Pan troglodytes (chimpanzee)AGXTXP_003309627.2
Macaca mulatta (Rhesus monkey)AGXTXP_001090301.2
Canis lupus familiaris (dog)LOC100855679XP_003639939.1
Canis lupus familiaris (dog)LOC607355XP_848328.2
Bos taurus (cattle)AGXTNP_001095825.1
Mus musculus (house mouse)AgxtNP_057911.2
Rattus norvegicus (Norway rat)AgxtNP_085914.2
Gallus gallus (chicken)AGXTXP_003641783.2
Danio rerio (zebrafish)agxtaNP_001002331.1
Danio rerio (zebrafish)agxtbNP_998327.1
Drosophila melanogaster (fruit fly)SpatNP_511062.1
Caenorhabditis elegansT14D7.1NP_495885.1
Arabidopsis thaliana (thale cress)AGTNP_178969.1
Xenopus (Silurana) tropicalis (western clawed frog)agxtNP_001006705.1
Process
IDNameEvidence
GO:0006625protein targeting to peroxisomeIMP
GO:0009436glyoxylate catabolic processIDA
GO:0019265glycine biosynthetic process, by transamination of glyoxylateIDA
GO:0019448L-cysteine catabolic processIDA
GO:0034641cellular nitrogen compound metabolic processTAS
GO:0042853L-alanine catabolic processIDA
GO:0042866pyruvate biosynthetic processIEA
GO:0044281small molecule metabolic processTAS
GO:0046487glyoxylate metabolic processIMP
GO:0046487glyoxylate metabolic processTAS
GO:0046724oxalic acid secretionIEA
GO:0051384response to glucocorticoidIEA
GO:0051591response to cAMPIEA
Component
IDNameEvidence
GO:0005759mitochondrial matrixIEA
GO:0005777peroxisomeIDA
GO:0005782peroxisomal matrixIDA
GO:0005782peroxisomal matrixTAS
Function
IDNameEvidence
GO:0004760serine-pyruvate transaminase activityIEA
GO:0005102receptor bindingIPI
GO:0005515protein bindingIPI
GO:0008453alanine-glyoxylate transaminase activityIDA
GO:0008453alanine-glyoxylate transaminase activityTAS
GO:0008483transaminase activityIDA
GO:0016597amino acid bindingIDA
GO:0030170pyridoxal phosphate bindingIDA
GO:0030170pyridoxal phosphate bindingIMP
GO:0042803protein homodimerization activityIDA
GeneCards AGXT
PDB 1H0C, 2YOB, 4I8A, 3R9A, 1J04
UniProt P21549
Vega OTTHUMG00000133354
MIM 604285
Ensembl ENSG00000172482
HGNC 341
HPRD 05048

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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