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Sequence in raw or FASTA format:


Blast Method:


MEGF8 multiple EGF-like-domains 8 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001271938 Homo sapiens multiple EGF-like-domains 8 (MEGF8), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
NM_001410 Homo sapiens multiple EGF-like-domains 8 (MEGF8), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $4749.00 40

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Gene Symbol MEGF8
Entrez Gene ID 1954
Full Name multiple EGF-like-domains 8
Synonyms C19orf49, CRPT2, EGFL4, SBP1
General protein information
Preferred Names
multiple epidermal growth factor-like domains protein 8
multiple epidermal growth factor-like domains protein 8
EGF-like-domain, multiple 4
HBV pre-s2 binding protein 1
EGF-like domain-containing protein 4
epidermal growth factor-like protein 4
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].

MIM: 604267

mRNA Protein Product Sequence Price Select
NM_001271938, 429836858 NP_001258867, 429836859 multiple epidermal growth factor-like domains protein 8 isoform 1 precursor ORF Sequence $4500.00
NM_001410, 145701024 NP_001401, 145701025 multiple epidermal growth factor-like domains protein 8 isoform 2 precursor ORF Sequence $4500.00
Homo sapiens (human)MEGF8NP_001258867.1
Pan troglodytes (chimpanzee)MEGF8XP_003316429.1
Macaca mulatta (Rhesus monkey)LOC709352XP_002808242.1
Canis lupus familiaris (dog)MEGF8XP_541588.5
Bos taurus (cattle)MEGF8XP_002695193.3
Mus musculus (house mouse)Megf8NP_001153872.1
Rattus norvegicus (Norway rat)Megf8NP_446080.1
Danio rerio (zebrafish)megf8XP_005158088.1
Drosophila melanogaster (fruit fly)CG7466NP_609180.2
Xenopus (Silurana) tropicalis (western clawed frog)megf8XP_002936442.2
GO:0003143embryonic heart tube morphogenesisISS
GO:0010468regulation of gene expressionISS
GO:0030326embryonic limb morphogenesisISS
GO:0030509BMP signaling pathwayISS
GO:0035108limb morphogenesisIMP
GO:0042074cell migration involved in gastrulationIMP
GO:0048704embryonic skeletal system morphogenesisISS
GO:0048842positive regulation of axon extension involved in axon guidanceISS
GO:0055113epiboly involved in gastrulation with mouth forming secondIMP
GO:0060971embryonic heart tube left/right pattern formationISS
GO:0060972left/right pattern formationIMP
GO:0061371determination of heart left/right asymmetryIMP
GO:0071907determination of digestive tract left/right asymmetryISS
GO:0097094craniofacial suture morphogenesisIMP
GO:0097155fasciculation of sensory neuron axonISS
GO:0016021integral component of membraneIEA
GO:0070062extracellular vesicular exosomeIDA
GO:0004872receptor activityIEA
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GeneCards MEGF8
UniProt Q7Z7M0
Vega OTTHUMG00000150342
MIM 604267
Ensembl ENSG00000105429
HGNC 3233
HPRD 10370

What is the normal function of the MEGF8 gene?

The MEGF8 gene provides instructions for making a protein whose function is unclear. Based on its structure, the Megf8 protein may be involved in cell processes such as attaching cells to one another (cell adhesion) and helping proteins interact with each other. Researchers also suspect that the Megf8 protein plays a role in the normal shaping (patterning) of many parts of the body during embryonic development.


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