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Sequence in raw or FASTA format:

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ACSF3 acyl-CoA synthetase family member 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001127214 Homo sapiens acyl-CoA synthetase family member 3 (ACSF3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001243279 Homo sapiens acyl-CoA synthetase family member 3 (ACSF3), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001284316 Homo sapiens acyl-CoA synthetase family member 3 (ACSF3), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_174917 Homo sapiens acyl-CoA synthetase family member 3 (ACSF3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005256293 PREDICTED: Homo sapiens acyl-CoA synthetase family member 3 (ACSF3), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006721166 PREDICTED: Homo sapiens acyl-CoA synthetase family member 3 (ACSF3), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

Gene Symbol ACSF3
Entrez Gene ID 197322
Full Name acyl-CoA synthetase family member 3
Synonyms
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16q24.3

Summary This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Sep 2013].
Disorder

MIM: 614245

mRNA Protein Product Sequence Price Select
NM_001127214, 546232249 NP_001120686, 187761345 acyl-CoA synthetase family member 3, mitochondrial isoform 1 precursor ORF Sequence $700.00
NM_001243279, 546232257 NP_001230208, 343168767 acyl-CoA synthetase family member 3, mitochondrial isoform 1 precursor ORF Sequence $700.00
NM_001284316, 546232250 NP_001271245, 546232251 acyl-CoA synthetase family member 3, mitochondrial isoform 2 ORF Sequence $300.00
NM_174917, 546232236 NP_777577, 187761343 acyl-CoA synthetase family member 3, mitochondrial isoform 1 precursor ORF Sequence $700.00
XM_005256293, 530424687 XP_005256350, 530424688 acyl-CoA synthetase family member 3, mitochondrial isoform X1 ORF Sequence $700.00
XM_006721166, 578828904 XP_006721229, 578828905 acyl-CoA synthetase family member 3, mitochondrial isoform X2 ORF Sequence $550.00
Homo sapiens (human)ACSF3NP_777577.2
Pan troglodytes (chimpanzee)ACSF3XP_511166.3
Canis lupus familiaris (dog)ACSF3XP_005620620.1
Bos taurus (cattle)ACSF3NP_001030240.1
Mus musculus (house mouse)Acsf3NP_659181.2
Rattus norvegicus (Norway rat)Acsf3XP_574249.3
Gallus gallus (chicken)ACSF3XP_004944364.1
Danio rerio (zebrafish)LOC562292XP_690782.2
Arabidopsis thaliana (thale cress)AT3G16170NP_566537.1
Xenopus (Silurana) tropicalis (western clawed frog)acsf3NP_001121382.2
Process
IDNameEvidence
GO:0006631fatty acid metabolic processIDA
GO:0006633fatty acid biosynthetic processIDA
GO:0090410malonate catabolic processIDA
Component
IDNameEvidence
GO:0005739mitochondrionIDA
Function
IDNameEvidence
GO:0005524ATP bindingIEA
GO:0016878acid-thiol ligase activityIDA
GO:0090409malonyl-CoA synthetase activityIDA
GeneCards ACSF3
UniProt Q4G176, F5H5A1
Vega OTTHUMG00000138044
MIM 614245
Ensembl ENSG00000176715
HGNC 27288
HPRD 14117

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ACSF3 gene?

The ACSF3 gene provides instructions for making an enzyme involved in the formation (synthesis) of fatty acids, which are building blocks used to make fats (lipids). The ACSF3 enzyme performs a chemical reaction that converts malonic acid to malonyl-CoA, which is the first step of fatty acid synthesis. Based on this activity, the enzyme is classified as a malonyl-CoA synthetase. The ACSF3 enzyme also converts methylmalonic acid to methylmalonyl-CoA, making it a methylmalonyl-CoA synthetase as well.

Fatty acid synthesis occurs through two pathways, one of which takes place in cellular structures called mitochondria. Mitochondria convert the energy from food into a form that cells can use, and fatty acid synthesis in these structures is thought to be important for their proper functioning. The ACSF3 enzyme is found only in mitochondria and is involved in mitochondrial fatty acid synthesis.

Interactant

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