A2M alpha-2-macroglobulin [Homo sapiens (human)]
| Gene Symbol | A2M |
| Entrez Gene ID | 2 |
| Full Name | alpha-2-macroglobulin |
| Synonyms | CPAMD5, DKFZp779B086, S863-7 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
12 12p13.31 |
| Summary | Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq]. |
| Disorder | MIM: 103950 Emphysema due to alpha-2-macroglobulin deficiency (1); {Alzheimer |
| mRNA | NM_000014, 66932946 |
| Protein | NP_000005, 66932947 |
| Product | alpha-2-macroglobulin precursor |
| RefSeq Status | REVIEWED |
| hsa04610 | Complement and coagulation cascades |
WikiPathways
| WP558 | Complement and Coagulation Cascades |
Pathway Interaction Database
| il6_7pathway | IL6-mediated signaling events |
Reactome
| REACT_22258 | Metabolism of lipids and lipoproteins |
| REACT_20 | Formation of Platelet plug |
| REACT_11051 | Rho GTPase cycle |
| REACT_604 | Hemostasis |
| REACT_602 | Lipid digestion, mobilization, and transport |
| REACT_11044 | Signaling by Rho GTPases |
| REACT_798 | Platelet Activation |
| REACT_1280 | Response to elevated platelet cytosolic Ca2+ |
| REACT_2051 | Formation of Fibrin Clot (Clotting Cascade) |
| REACT_318 | Platelet degranulation |
| REACT_326 | Intrinsic Pathway |
| REACT_6823 | Lipoprotein metabolism |
| REACT_13621 | HDL-mediated lipid transport |
| Homo sapiens (human) | A2M | NP_000005.2 |
| Pan troglodytes (chimpanzee) | A2M | XP_001139819.1 |
| Canis lupus familiaris (dog) | A2M | XP_534893.2 |
| Bos taurus (cattle) | A2M | NP_001103265.1 |
| Mus musculus (house mouse) | A2m | NP_783327.1 |
| Rattus norvegicus (Norway rat) | A2m | NP_036620.1 |
| Gallus gallus (chicken) | A2M | XP_416476.2 |
| Danio rerio (zebrafish) | LOC100003785 | XP_001921519.2 |
| Danio rerio (zebrafish) | zgc:165518 | NP_001093623.1 |
| Danio rerio (zebrafish) | zgc:165453 | XP_001918704.2 |
| Danio rerio (zebrafish) | sb:cb37 | XP_001345541.3 |
| Danio rerio (zebrafish) | wu:fb68b01 | XP_001345569.2 |
| Danio rerio (zebrafish) | a2ml | NP_001132951.1 |
| Danio rerio (zebrafish) | LOC100006925 | XP_001921577.2 |
| Danio rerio (zebrafish) | LOC100006895 | XP_001923676.1 |
| Danio rerio (zebrafish) | LOC100006782 | XP_001345438.3 |
| Danio rerio (zebrafish) | LOC569025 | XP_697477.4 |
| Danio rerio (zebrafish) | si:dkey-46g23.2 | XP_001332356.1 |
| Danio rerio (zebrafish) | zgc:171446 | NP_001108028.1 |
| Danio rerio (zebrafish) | LOC100334394 | XP_002662078.1 |
| Danio rerio (zebrafish) | zgc:171445 | NP_001107101.1 |
| Danio rerio (zebrafish) | si:dkey-46g23.3 | NP_001108188.1 |
| Danio rerio (zebrafish) | zgc:171426 | NP_001108172.1 |
| Danio rerio (zebrafish) | LOC100333361 | XP_002661073.1 |
| Danio rerio (zebrafish) | LOC100330604 | XP_002667658.1 |
| ID | Name | Evidence |
| GO:0001869 | negative regulation of complement activation, lectin pathway | IDA |
| GO:0002576 | platelet degranulation | TAS |
| GO:0006953 | acute-phase response | IEA |
| GO:0007264 | small GTPase mediated signal transduction | TAS |
| GO:0007584 | response to nutrient | IEA |
| GO:0007596 | blood coagulation | TAS |
| GO:0007597 | blood coagulation, intrinsic pathway | TAS |
| GO:0010037 | response to carbon dioxide | IEA |
| GO:0030168 | platelet activation | TAS |
| GO:0043547 | positive regulation of GTPase activity | TAS |
| GO:0051056 | regulation of small GTPase mediated signal transduction | TAS |
| GO:0051384 | response to glucocorticoid stimulus | IEA |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | NAS |
| GO:0005576 | extracellular region | TAS |
| GO:0005615 | extracellular space | IEA |
| GO:0005829 | cytosol | TAS |
| GO:0031093 | platelet alpha granule lumen | TAS |
Function
| ID | Name | Evidence |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IDA |
| GO:0005096 | GTPase activator activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO:0019838 | growth factor binding | IDA |
| GO:0019899 | enzyme binding | IPI |
| GO:0019959 | interleukin-8 binding | IPI |
| GO:0019966 | interleukin-1 binding | IDA |
| GO:0043120 | tumor necrosis factor binding | IDA |
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