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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


A2M alpha-2-macroglobulin [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000014 Homo sapiens alpha-2-macroglobulin (A2M), mRNA. ORF Sequence $1548.75
Peptide Services
Antibody Services
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Gene Symbol A2M
Entrez Gene ID 2
Full Name alpha-2-macroglobulin
Synonyms CPAMD5, DKFZp779B086, S863-7
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p13.31

Summary Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008].
Disorder

MIM: 103950

Emphysema due to alpha-2-macroglobulin deficiency (1); {Alzheimer

mRNA Protein Product Sequence Price Select
NM_000014, 66932946 NP_000005, 66932947 alpha-2-macroglobulin precursor Full Length $1637.30
ORF Sequence $1548.75
KEGG
hsa04610Complement and coagulation cascades
WikiPathways
WP558Complement and Coagulation Cascades
Pathway Interaction Database
il6_7pathwayIL6-mediated signaling events
Reactome
REACT_6823Lipoprotein metabolism
REACT_13621HDL-mediated lipid transport
REACT_11051Rho GTPase cycle
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_602Lipid digestion, mobilization, and transport
REACT_604Hemostasis
REACT_11044Signaling by Rho GTPases
REACT_798Platelet activation, signaling and aggregation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_318Platelet degranulation
REACT_111102Signal Transduction
REACT_326Intrinsic Pathway
Homo sapiens (human)A2MNP_000005.2
Pan troglodytes (chimpanzee)A2MXP_001139819.1
Macaca mulatta (Rhesus monkey)A2MXP_001114328.1
Canis lupus familiaris (dog)A2MXP_534893.3
Bos taurus (cattle)A2MNP_001103265.1
Mus musculus (house mouse)A2mNP_783327.2
Rattus norvegicus (Norway rat)A2mNP_036620.2
Gallus gallus (chicken)A2MXP_416476.3
Danio rerio (zebrafish)LOC100003785XP_001921519.3
Danio rerio (zebrafish)zgc:165518NP_001093623.2
Danio rerio (zebrafish)LOC100006782XP_001345438.4
Danio rerio (zebrafish)LOC100006895XP_001923676.1
Danio rerio (zebrafish)sb:cb37XP_001345541.4
Danio rerio (zebrafish)wu:fb68b01XP_001345569.2
Danio rerio (zebrafish)a2mlNP_001132951.1
Danio rerio (zebrafish)LOC100006925XP_001921577.2
Danio rerio (zebrafish)a2ml1XP_697477.5
Danio rerio (zebrafish)zgc:171426XP_003198073.1
Danio rerio (zebrafish)si:dkey-46g23.5NP_001188334.1
Danio rerio (zebrafish)si:dkey-46g23.2XP_001332356.1
Danio rerio (zebrafish)zgc:171446NP_001108028.1
Danio rerio (zebrafish)zgc:171445NP_001107101.1
Danio rerio (zebrafish)zgc:165453XP_001918704.3
GeneCards A2M
PDB 2P9R, 4ACQ, 1BV8
UniProt P01023
MIM 103950
Ensembl ENSG00000175899
HGNC 7
HPRD 00072

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
alpha-2-macroglobulin
Names
alpha-2-macroglobulin
alpha-2-M
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

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