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A2M alpha-2-macroglobulin [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000014 Homo sapiens alpha-2-macroglobulin (A2M), mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006719056 PREDICTED: Homo sapiens alpha-2-macroglobulin (A2M), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $2699.00 30

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Gene Symbol A2M
Entrez Gene ID 2
Full Name alpha-2-macroglobulin
Synonyms A2MD, CPAMD5, FWP007, S863-7
General protein information
Preferred Names
alpha-2-macroglobulin
Names
alpha-2-macroglobulin
alpha-2-M
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p13.31

Summary Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008].
Disorder

MIM: 103950

Emphysema due to alpha-2-macroglobulin deficiency (1); {Alzheimer

mRNA Protein Product Sequence Price Select
NM_000014, 66932946 NP_000005, 66932947 alpha-2-macroglobulin precursor ORF Sequence $1500.00
XM_006719056, 578822813 XP_006719119, 578822814 alpha-2-macroglobulin isoform X1 ORF Sequence $2500.00
KEGG
hsa04610Complement and coagulation cascades
Pathway Interaction Database
il6_7pathwayIL6-mediated signaling events
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_326Intrinsic Pathway
REACT_318Platelet degranulation
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_13621HDL-mediated lipid transport
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
REACT_11044Signaling by Rho GTPases
REACT_11051Rho GTPase cycle
REACT_22258Metabolism of lipids and lipoproteins
REACT_111102Signal Transduction
REACT_111217Metabolism
REACT_118779Extracellular matrix organization
REACT_118572Degradation of the extracellular matrix
Homo sapiens (human)A2MNP_000005.2
Pan troglodytes (chimpanzee)A2MXP_001139819.1
Macaca mulatta (Rhesus monkey)A2MXP_001114328.1
Canis lupus familiaris (dog)A2MXP_534893.3
Bos taurus (cattle)A2MNP_001103265.1
Mus musculus (house mouse)A2mNP_783327.2
Rattus norvegicus (Norway rat)A2mNP_036620.2
Rattus norvegicus (Norway rat)LOC100911545XP_003749876.1
Gallus gallus (chicken)A2MXP_416476.3
Danio rerio (zebrafish)LOC100003785XP_005157599.1
Danio rerio (zebrafish)zgc:165518NP_001093623.2
Danio rerio (zebrafish)sb:cb37XP_001345541.5
Danio rerio (zebrafish)si:dkey-52d15.2XP_001345569.3
Danio rerio (zebrafish)a2mlNP_001132951.1
Danio rerio (zebrafish)LOC100006925XP_001921577.3
Danio rerio (zebrafish)LOC100006895XP_001923676.1
Danio rerio (zebrafish)LOC100006782XP_001345438.5
Danio rerio (zebrafish)a2ml1XP_697477.6
Danio rerio (zebrafish)zgc:171426XP_003198073.1
Danio rerio (zebrafish)si:dkey-46g23.5NP_001188334.1
Danio rerio (zebrafish)si:dkey-46g23.2XP_001332356.1
Danio rerio (zebrafish)zgc:171446NP_001108028.1
Danio rerio (zebrafish)zgc:171445NP_001107101.1
Danio rerio (zebrafish)zgc:165453XP_001918704.3
Xenopus (Silurana) tropicalis (western clawed frog)LOC100489060XP_002938549.2
Xenopus (Silurana) tropicalis (western clawed frog)a2mXP_002938550.2
Process
IDNameEvidence
GO:0001869negative regulation of complement activation, lectin pathwayIDA
GO:0002576platelet degranulationTAS
GO:0007264small GTPase mediated signal transductionTAS
GO:0007596blood coagulationTAS
GO:0007597blood coagulation, intrinsic pathwayTAS
GO:0010951negative regulation of endopeptidase activityIDA
GO:0010951negative regulation of endopeptidase activityIEA
GO:0022617extracellular matrix disassemblyTAS
GO:0030168platelet activationTAS
GO:0030198extracellular matrix organizationTAS
GO:0048863stem cell differentiationIEA
GO:0051056regulation of small GTPase mediated signal transductionTAS
Component
IDNameEvidence
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005829cytosolTAS
GO:0031093platelet alpha granule lumenTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0002020protease bindingIPI
GO:0004867serine-type endopeptidase inhibitor activityIDA
GO:0005102receptor bindingIMP
GO:0005515protein bindingIPI
GO:0019838growth factor bindingIDA
GO:0019899enzyme bindingIPI
GO:0019959interleukin-8 bindingIPI
GO:0019966interleukin-1 bindingIDA
GO:0043120tumor necrosis factor bindingIDA
GO:0048306calcium-dependent protein bindingIPI
GeneCards A2M
PDB 2P9R, 4ACQ, 1BV8
UniProt P01023
Vega OTTHUMG00000150267
MIM 103950
Ensembl ENSG00000175899
HGNC 7
HPRD 00072

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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