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LIPH lipase, member H [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_139248 Homo sapiens lipase, member H (LIPH), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
XM_006713529 PREDICTED: Homo sapiens lipase, member H (LIPH), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006713530 PREDICTED: Homo sapiens lipase, member H (LIPH), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

Gene Symbol LIPH
Entrez Gene ID 200879
Full Name lipase, member H
Synonyms AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q27

Summary This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008].
Disorder

MIM: 607365

Hypotrichosis, localized, autosomal recessive 2, 604379 (3);

mRNA Protein Product Sequence Price Select
NM_139248, 62241034 NP_640341, 21245106 lipase member H precursor ORF Sequence $360.00
XM_006713529, 578807135 XP_006713592, 578807136 lipase member H isoform X1 ORF Sequence $550.00
XM_006713530, 578807137 XP_006713593, 578807138 lipase member H isoform X2 ORF Sequence $550.00
Homo sapiens (human)LIPHNP_640341.1
Pan troglodytes (chimpanzee)LIPHXP_516924.3
Canis lupus familiaris (dog)LIPHXP_003640181.2
Bos taurus (cattle)LIPHXP_002684916.2
Mus musculus (house mouse)LiphNP_001077363.1
Rattus norvegicus (Norway rat)LiphNP_001037744.1
Gallus gallus (chicken)LIPIXP_416675.2
Danio rerio (zebrafish)zgc:91985NP_001003499.1
Danio rerio (zebrafish)lipiXP_001342691.1
Xenopus (Silurana) tropicalis (western clawed frog)liphNP_001011098.1
Process
IDNameEvidence
GO:0016042lipid catabolic processIDA
Component
IDNameEvidence
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneIDA
Function
IDNameEvidence
GO:0004620phospholipase activityIDA
GO:0008201heparin bindingIDA
GeneCards LIPH
UniProt A2IBA6, Q8WWY8
Vega OTTHUMG00000156657
MIM 607365
Ensembl ENSG00000163898
HGNC 18483
HPRD 07392

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the LIPH gene?

The LIPH gene provides instructions for making an enzyme called lipase H. This enzyme is found in many cells and tissues, where it breaks down the molecule phosphatidic acid into lysophosphatidic acid (LPA) and free fatty acid. LPA is a ligand, which means that it attaches (binds) to certain proteins called receptors. A ligand and its receptor fit together like a key in a lock. LPA has multiple receptors and is involved in many cellular functions, such as cell growth and division (proliferation), cell movement (migration), and the self-destruction of cells (apoptosis).

One of LPA's receptors, the LPA6 protein, regulates the proliferation and maturation (differentiation) of cells within hair follicles, which are specialized structures in the skin where hair growth occurs. These cell processes are important for the normal development of hair follicles and for hair growth; as the cells in the hair follicle divide, the hair strand (shaft) is pushed upward and extends beyond the skin, causing the hair to grow. Lipase H is also found in the outermost layer of skin (the epidermis) and glands in the skin that produce a substance that protects the skin and hair (sebaceous glands).

Interactant

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