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Sequence in raw or FASTA format:

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Six3 sine oculis-related homeobox 3 [Mus musculus (house mouse)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_011381 Mus musculus sine oculis-related homeobox 3 (Six3), mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol Six3
Entrez Gene ID 20473
Full Name sine oculis-related homeobox 3
Synonyms E130112M24Rik, Six3a, Six3alpha, Six3b, Six3beta
General protein information
Preferred Names
homeobox protein SIX3
Names
homeobox protein SIX3
sine oculis homeobox homolog 3
sine oculis-related homeobox 3 homolog
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

17

17 E4|17 55.42 cM

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_011381, 258613883 NP_035511, 59939908 homeobox protein SIX3 ORF Sequence $400.00
Homo sapiens (human)SIX3NP_005404.1
Pan troglodytes (chimpanzee)SIX3XP_525749.4
Canis lupus familiaris (dog)SIX3XP_538477.4
Bos taurus (cattle)SIX3NP_001180053.1
Mus musculus (house mouse)Six3NP_035511.2
Rattus norvegicus (Norway rat)Six3NP_076480.1
Gallus gallus (chicken)SIX3NP_989695.1
Danio rerio (zebrafish)six3aNP_571437.1
Xenopus (Silurana) tropicalis (western clawed frog)six3XP_002944388.2
Process
IDNameEvidence
GO:0001654eye developmentIDA
GO:0006366transcription from RNA polymerase II promoterIDA
GO:0006606protein import into nucleusIDA
GO:0007275multicellular organismal developmentIEA
GO:0007420brain developmentIMP
GO:0021536diencephalon developmentIGI
GO:0021537telencephalon developmentIMP
GO:0021797forebrain anterior/posterior pattern specificationIGI
GO:0021797forebrain anterior/posterior pattern specificationIMP
GO:0030178negative regulation of Wnt signaling pathwayIMP
GO:0043010camera-type eye developmentIGI
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045892negative regulation of transcription, DNA-templatedISO
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0048512circadian behaviorIMP
GO:0060235lens induction in camera-type eyeIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
Function
IDNameEvidence
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIDA
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDA
GO:0003677DNA bindingIDA
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDA
GO:0005102receptor bindingISO
GO:0005515protein bindingIPI
GO:0043565sequence-specific DNA bindingIDA
GeneCards Six3
UniProt Q62233
MGI 102764

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

What is the normal function of the SIX3 gene?

The SIX3 gene provides instructions for making a protein that plays an important role in the development of the eyes and front part of the brain (forebrain). This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. The SIX3 protein regulates genes involved in several signaling pathways that are important for embryonic development. Some of these genes are turned on (activated) by the SIX3 protein and others are turned off (repressed).

One gene that is activated by the SIX3 protein is the SHH gene, which provides instructions for making a protein called Sonic Hedgehog. Among its many functions, Sonic Hedgehog helps establish the right and left halves (hemispheres) of the forebrain. The SIX3 protein also regulates genes involved in the formation of the lens of the eye and the specialized tissue at the back of the eye that detects light and color (the retina).

Interactant

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