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FGF8 fibroblast growth factor 8 (androgen-induced) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001206389 Homo sapiens fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant G, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_006119 Homo sapiens fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant B, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_033163 Homo sapiens fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant F, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_033164 Homo sapiens fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant E, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_033165 Homo sapiens fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant A, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

*Business Day

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Gene Symbol FGF8
Entrez Gene ID 2253
Full Name fibroblast growth factor 8 (androgen-induced)
Synonyms AIGF, FGF-8, HBGF-8, HH6, KAL6
General protein information
Preferred Names
fibroblast growth factor 8
Names
fibroblast growth factor 8
androgen-induced growth factor
heparin-binding growth factor 8
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q24

Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600483

Kallmann syndrome 6, 612702 (3)

mRNA Protein Product Sequence Price Select
NM_001206389, 329755302 NP_001193318, 329755303 fibroblast growth factor 8 isoform G ORF Sequence $99.00
NM_006119, 298919217 NP_006110, 5174439 fibroblast growth factor 8 isoform B precursor ORF Sequence $159.00
NM_033163, 298919216 NP_149353, 15147346 fibroblast growth factor 8 isoform F precursor ORF Sequence $159.00
NM_033164, 298919214 NP_149354, 15147348 fibroblast growth factor 8 isoform E precursor ORF Sequence $250.00
NM_033165, 298919215 NP_149355, 15147350 fibroblast growth factor 8 isoform A precursor ORF Sequence $159.00
KEGG
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
hsa05205Proteoglycans in cancer
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
WikiPathways
WP1591Heart Development
WP51Regulation of Actin Cytoskeleton
WP2064Neural Crest Differentiation
Reactome
REACT_9470Signaling by FGFR
REACT_9452FGFR4 ligand binding and activation
REACT_12578GAB1 signalosome
REACT_9510FGFR3c ligand binding and activation
REACT_9417Signaling by EGFR
REACT_9396FGFR ligand binding and activation
REACT_9413FGFR2c ligand binding and activation
REACT_9483FGFR1 ligand binding and activation
REACT_9439FGFR3 ligand binding and activation
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_9508FGFR3b ligand binding and activation
REACT_17025Downstream signal transduction
REACT_9515FGFR1c ligand binding and activation
REACT_976PI3K Cascade
REACT_762IRS-related events
REACT_11061Signalling by NGF
REACT_1195Insulin receptor signalling cascade
REACT_12464PI3K/AKT activation
REACT_498Signaling by Insulin receptor
REACT_332IRS-mediated signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_9390FGFR2 ligand binding and activation
REACT_21272Downstream signaling of activated FGFR
REACT_21310Phospholipase C-mediated cascade
REACT_21270PI-3K cascade
REACT_21247FRS2-mediated cascade
REACT_21374SHC-mediated cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111102Signal Transduction
REACT_111184Negative regulation of FGFR signaling
REACT_111040Signaling by SCF-KIT
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115596Signaling by ERBB4
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_121153Signaling by activated point mutants of FGFR1
REACT_121155Signaling by FGFR2 mutants
REACT_120863Activated point mutants of FGFR2
REACT_121249Signaling by FGFR3 mutants
REACT_121398Signaling by FGFR mutants
REACT_120999Signaling by FGFR1 mutants
REACT_121337Signaling by activated point mutants of FGFR3
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
Homo sapiens (human)FGF8NP_149353.1
Bos taurus (cattle)FGF8NP_001193607.1
Mus musculus (house mouse)Fgf8NP_001159833.1
Rattus norvegicus (Norway rat)Fgf8NP_579820.1
Gallus gallus (chicken)FGF8NP_001012785.1
Danio rerio (zebrafish)fgf8aNP_571356.2
Xenopus (Silurana) tropicalis (western clawed frog)fgf8NP_001008163.1
Process
IDNameEvidence
GO:0000165MAPK cascadeIEA
GO:0001569patterning of blood vesselsIEA
GO:0001656metanephros developmentIEP
GO:0001658branching involved in ureteric bud morphogenesisIEA
GO:0001759organ inductionIEA
GO:0001823mesonephros developmentIEP
GO:0001839neural plate morphogenesisIEA
GO:0001947heart loopingIEA
GO:0001974blood vessel remodelingIEA
GO:0003148outflow tract septum morphogenesisISS
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formationISS
GO:0006915apoptotic processIEA
GO:0006979response to oxidative stressIEA
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007369gastrulationNAS
GO:0008045motor neuron axon guidanceIEA
GO:0008078mesodermal cell migrationIEA
GO:0008284positive regulation of cell proliferationIDA
GO:0008284positive regulation of cell proliferationIEA
GO:0008286insulin receptor signaling pathwayTAS
GO:0008406gonad developmentIMP
GO:0008543fibroblast growth factor receptor signaling pathwayIGI
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0009653anatomical structure morphogenesisNAS
GO:0010628positive regulation of gene expressionIEA
GO:0014070response to organic cyclic compoundIEA
GO:0021543pallium developmentIEA
GO:0021544subpallium developmentIEA
GO:0021798forebrain dorsal/ventral pattern formationIEA
GO:0021846cell proliferation in forebrainIEA
GO:0021884forebrain neuron developmentIEA
GO:0023019signal transduction involved in regulation of gene expressionIEA
GO:0030509BMP signaling pathwayIEA
GO:0030539male genitalia developmentIEA
GO:0030878thyroid gland developmentIEA
GO:0030916otic vesicle formationIEA
GO:0030917midbrain-hindbrain boundary developmentIEA
GO:0033563dorsal/ventral axon guidanceIEA
GO:0035116embryonic hindlimb morphogenesisIEA
GO:0035909aorta morphogenesisIEA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042476odontogenesisIEP
GO:0042487regulation of odontogenesis of dentin-containing toothIEA
GO:0042493response to drugIEA
GO:0043524negative regulation of neuron apoptotic processIEA
GO:0045087innate immune responseTAS
GO:0045840positive regulation of mitosisIEA
GO:0046622positive regulation of organ growthIEA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048853forebrain morphogenesisIEA
GO:0050918positive chemotaxisIEA
GO:0051781positive regulation of cell divisionIEA
GO:0055026negative regulation of cardiac muscle tissue developmentIMP
GO:0060037pharyngeal system developmentIEA
GO:0060070canonical Wnt signaling pathwayIEA
GO:0060128corticotropin hormone secreting cell differentiationIEA
GO:0060129thyroid-stimulating hormone-secreting cell differentiationIEA
GO:0060348bone developmentIMP
GO:0060425lung morphogenesisIEA
GO:0060445branching involved in salivary gland morphogenesisIEA
GO:0060563neuroepithelial cell differentiationIDA
GO:0071542dopaminergic neuron differentiationIDA
GO:0090134cell migration involved in mesendoderm migrationIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0009897external side of plasma membraneIEA
Function
IDNameEvidence
GO:0005104fibroblast growth factor receptor bindingIEA
GO:0005105type 1 fibroblast growth factor receptor bindingIDA
GO:0005111type 2 fibroblast growth factor receptor bindingIDA
GO:0008083growth factor activityIDA
GO:0008083growth factor activityIEA
GO:0042056chemoattractant activityIEA
GeneCards FGF8
UniProt P55075, A1A515
MIM 600483
HGNC 3686
HPRD 02727

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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