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AAK1 AP2 associated kinase 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25045 NM_014911 Homo sapiens AP2 associated kinase 1 (AAK1), mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25045C NM_014911 Homo sapiens AP2 associated kinase 1 (AAK1), mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol AAK1
Entrez Gene ID 22848
Full Name AP2 associated kinase 1
Synonyms
General protein information
Preferred Names
AP2-associated protein kinase 1
Names
AP2-associated protein kinase 1
adaptor-associated kinase 1
NP_055726.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p14

Summary Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_014911, 148277036 NP_055726, 148277037 AP2-associated protein kinase 1 ORF Sequence $750.00
Homo sapiens (human)AAK1NP_055726.3
Pan troglodytes (chimpanzee)AAK1XP_001138187.3
Canis lupus familiaris (dog)AAK1XP_005626238.1
Mus musculus (house mouse)Aak1NP_001035195.1
Rattus norvegicus (Norway rat)Aak1NP_001166921.1
Gallus gallus (chicken)AAK1XP_417663.4
Process
IDNameEvidence
GO:0006468protein phosphorylationIDA
GO:0006897endocytosisIEA
GO:0032880regulation of protein localizationIDA
GO:0045747positive regulation of Notch signaling pathwayIDA
GO:0046777protein autophosphorylationISS
GO:0050821protein stabilizationIDA
GO:2000369regulation of clathrin-mediated endocytosisIDA
GO:2000369regulation of clathrin-mediated endocytosisIMP
Component
IDNameEvidence
GO:0005905coated pitIEA
GO:0019897extrinsic component of plasma membraneISS
GO:0030136clathrin-coated vesicleISS
GO:0031252cell leading edgeISS
GO:0043195terminal boutonISS
Function
IDNameEvidence
GO:0004674protein serine/threonine kinase activityISS
GO:0005112Notch bindingIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0035612AP-2 adaptor complex bindingIDA
GeneCards AAK1
UniProt Q2M2I8
HGNC 19679
HPRD 10620

Interactant

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