AAK1 AP2 associated kinase 1 [Homo sapiens (human)]
| Gene Symbol | AAK1 |
| Entrez Gene ID | 22848 |
| Full Name | AP2 associated kinase 1 |
| Synonyms | DKFZp686F03202, DKFZp686K16132, FLJ23712, FLJ25931, FLJ31060, FLJ42882, FLJ45252, KIAA1048, MGC138170, MGC164568, MGC164570 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
2 2p14 |
| Summary | Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]. |
| Disorder | MIM: |
| mRNA | NM_014911, 148277036 |
| Protein | NP_055726, 148277037 |
| Product | AP2-associated protein kinase 1 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | AAK1 | NP_055726.3 |
| Pan troglodytes (chimpanzee) | AAK1 | XP_001138098.1 |
| Mus musculus (house mouse) | Aak1 | NP_001035195.1 |
| Rattus norvegicus (Norway rat) | Aak1 | XP_575594.2 |
| Gallus gallus (chicken) | AAK1 | XP_417663.2 |
| Arabidopsis thaliana (thale cress) | AT2G32850 | NP_565756.1 |
| ID | Name | Evidence |
| GO:0006468 | protein phosphorylation | IEA |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IDA |
| GO:0005739 | mitochondrion | IDA |
| GO:0005886 | plasma membrane | IDA |
| GO:0005905 | coated pit | IEA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004674 | protein serine/threonine kinase activity | IEA |
| GO:0005524 | ATP binding | IEA |
| GeneCards | AAK1 |
| UniProt | Q2M2I8 |
| Ensembl | ENSG00000115977 |
| HGNC | 19679 |
| HPRD | 10620 |
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