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FBXW11 F-box and WD repeat domain containing 11 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu16260 NM_033644 Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu16300 NM_033645 Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17995 NM_012300 Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu39977 XM_005265855 PREDICTED: Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu39978 XM_005265856 PREDICTED: Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu39979 XM_005265857 PREDICTED: Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu39980 XM_005265858 PREDICTED: Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu39981 XM_005265859 PREDICTED: Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16260C NM_033644 Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu16300C NM_033645 Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu17995C NM_012300 Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu39977C XM_005265855 PREDICTED: Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu39978C XM_005265856 PREDICTED: Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00
OHu39979C XM_005265857 PREDICTED: Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant X3, mRNA. Customized vector On-demand 7-9 $269.00
OHu39980C XM_005265858 PREDICTED: Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant X4, mRNA. Customized vector On-demand 7-9 $269.00
OHu39981C XM_005265859 PREDICTED: Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant X5, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol FBXW11
Entrez Gene ID 23291
Full Name F-box and WD repeat domain containing 11
Synonyms BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos
General protein information
Preferred Names
F-box/WD repeat-containing protein 11
Names
F-box/WD repeat-containing protein 11
F-box protein Fbw1b
homologous to Slimb protein
F-box and WD-40 domain protein 11
F-box and WD-40 domain protein 1B
F-box/WD repeat-containing protein 1B
F-box and WD repeats protein beta-TrCP2
beta-transducin repeat-containing protein 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.1

Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605651

mRNA Protein Product Sequence Price Select
NM_012300, 48928049 NP_036432, 48928050 F-box/WD repeat-containing protein 11 isoform C ORF Sequence $550.00
NM_033644, 48928045 NP_387448, 48928046 F-box/WD repeat-containing protein 11 isoform B ORF Sequence $360.00
NM_033645, 48928047 NP_387449, 48928048 F-box/WD repeat-containing protein 11 isoform A ORF Sequence $550.00
XM_005265855, 578811054 XP_005265912, 530380933 F-box/WD repeat-containing protein 11 isoform X1 ORF Sequence $550.00
XM_005265856, 530380934 XP_005265913, 530380935 F-box/WD repeat-containing protein 11 isoform X2 ORF Sequence $550.00
XM_005265857, 530380936 XP_005265914, 530380937 F-box/WD repeat-containing protein 11 isoform X3 ORF Sequence $550.00
XM_005265858, 530380938 XP_005265915, 530380939 F-box/WD repeat-containing protein 11 isoform X4 ORF Sequence $550.00
XM_005265859, 530380940 XP_005265916, 530380941 F-box/WD repeat-containing protein 11 isoform X5 ORF Sequence $550.00
KEGG
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04710Circadian rhythm
hsa05131Shigellosis
hsa04114Oocyte meiosis
hsa_M00380SCF-BTRC complex
hsa04390Hippo signaling pathway
WikiPathways
WP231TNF-alpha/NF-kB Signaling Pathway
Pathway Interaction Database
ps1pathwayPresenilin action in Notch and Wnt signaling
hedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
plk1_pathwayPLK1 signaling events
wnt_canonical_pathwayCanonical Wnt signaling pathway
mtor_4pathwaymTOR signaling pathway
Reactome
REACT_152Cell Cycle, Mitotic
REACT_2203G2/M Transition
REACT_6900Immune System
REACT_21391Mitotic G2-G2/M phases
REACT_75774Adaptive Immune System
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_115566Cell Cycle
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_118656Activation of NF-kappaB in B cells
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_160315Regulation of PLK1 Activity at G2/M Transition
Homo sapiens (human)FBXW11NP_036432.2
Pan troglodytes (chimpanzee)FBXW11XP_518097.3
Macaca mulatta (Rhesus monkey)FBXW11XP_001097476.2
Canis lupus familiaris (dog)FBXW11XP_005619265.1
Bos taurus (cattle)FBXW11XP_005221479.1
Mus musculus (house mouse)Fbxw11NP_598776.1
Gallus gallus (chicken)FBXW11NP_001034351.1
Danio rerio (zebrafish)fbxw11bNP_998669.2
Danio rerio (zebrafish)fbxw11aNP_958467.1
Caenorhabditis eleganslin-23NP_495285.1
Process
IDNameEvidence
GO:0000086G2/M transition of mitotic cell cycleTAS
GO:0000209protein polyubiquitinationIDA
GO:0000278mitotic cell cycleTAS
GO:0006470protein dephosphorylationISS
GO:0016055Wnt signaling pathwayIEA
GO:0016567protein ubiquitinationIDA
GO:0016567protein ubiquitinationNAS
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic processIDA
GO:0031648protein destabilizationIMP
GO:0042347negative regulation of NF-kappaB import into nucleusIEA
GO:0042753positive regulation of circadian rhythmISS
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic processIDA
GO:0045862positive regulation of proteolysisIMP
GO:0045892negative regulation of transcription, DNA-templatedIMP
GO:0045893positive regulation of transcription, DNA-templatedISS
GO:0048511rhythmic processIEA
Component
IDNameEvidence
GO:0000151ubiquitin ligase complexNAS
GO:0005634nucleusISS
GO:0005813centrosomeIDA
GO:0005829cytosolISS
GO:0005829cytosolTAS
GO:0019005SCF ubiquitin ligase complexIDA
Function
IDNameEvidence
GO:0004842ubiquitin-protein transferase activityIDA
GO:0004842ubiquitin-protein transferase activityNAS
GO:0005515protein bindingIPI
GO:0046983protein dimerization activityIEA
GeneCards FBXW11
UniProt B4DH70, Q9UKB1
Vega OTTHUMG00000163267
MIM 605651
Ensembl ENSG00000072803
HGNC 13607
HPRD 07294

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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