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FBXW11 F-box and WD repeat domain containing 11 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_012300 Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant 3, mRNA. ORF Sequence $472.41
Peptide Services
Antibody Services
Protein Services
NM_033644 Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant 2, mRNA. ORF Sequence $461.10
Peptide Services
Antibody Services
Protein Services
NM_033645 Homo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant 1, mRNA. ORF Sequence $442.83
Peptide Services
Antibody Services
Protein Services


Gene Symbol FBXW11
Entrez Gene ID 23291
Full Name F-box and WD repeat domain containing 11
Synonyms BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos, KIAA0696
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.1

Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605651

mRNA Protein Product Sequence Price Select
NM_012300, 48928049 NP_036432, 48928050 F-box/WD repeat-containing protein 11 isoform C Full Length $1601.25
ORF Sequence $472.41
NM_033644, 48928045 NP_387448, 48928046 F-box/WD repeat-containing protein 11 isoform B Full Length $1587.60
ORF Sequence $461.10
NM_033645, 48928047 NP_387449, 48928048 F-box/WD repeat-containing protein 11 isoform A Full Length $1565.55
ORF Sequence $442.83
KEGG
hsa04710Circadian rhythm
hsa04120Ubiquitin mediated proteolysis
hsa04114Oocyte meiosis
hsa04340Hedgehog signaling pathway
hsa04310Wnt signaling pathway
hsa_M00380SCF-BTRC complex
hsa05131Shigellosis
WikiPathways
WP231TNF-alpha/NF-kB Signaling Pathway
Pathway Interaction Database
hedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
plk1_pathwayPLK1 signaling events
wnt_canonical_pathwayCanonical Wnt signaling pathway
ps1pathwayPresenilin action in Notch and Wnt signaling
mtor_4pathwaymTOR signaling pathway
Reactome
REACT_118656Activation of NF-kappaB in B Cells
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_75774Adaptive Immune System
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_6900Immune System
Homo sapiens (human)FBXW11NP_036432.2
Pan troglodytes (chimpanzee)FBXW11XP_518097.3
Macaca mulatta (Rhesus monkey)FBXW11XP_001097476.2
Canis lupus familiaris (dog)FBXW11XP_866627.1
Bos taurus (cattle)FBXW11XP_002696296.1
Mus musculus (house mouse)Fbxw11NP_598776.1
Gallus gallus (chicken)FBXW11NP_001034351.1
Danio rerio (zebrafish)fbxw11aNP_958467.1
Danio rerio (zebrafish)fbxw11bNP_998669.1
Caenorhabditis eleganslin-23NP_495285.1
GeneCards FBXW11
UniProt Q9UKB1
MIM 605651
Ensembl ENSG00000072803
HGNC 13607
HPRD 07294

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
F-box/WD repeat-containing protein 11
Names
F-box/WD repeat-containing protein 11
F-box protein Fbw1b
homologous to Slimb protein
F-box and WD-40 domain protein 11
F-box and WD-40 domain protein 1B
F-box/WD repeat-containing protein 1B
F-box and WD repeats protein beta-TrCP2
beta-transducin repeat-containing protein 2

Interactant

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