FBXW11 F-box and WD repeat domain containing 11 [Homo sapiens (human)]
| Gene Symbol | FBXW11 |
| Entrez Gene ID | 23291 |
| Full Name | F-box and WD repeat domain containing 11 |
| Synonyms | BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos, KIAA0696 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
5 5q35.1 |
| Summary | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq]. |
| Disorder | MIM: 605651 |
| mRNA | NM_033645, 48928047 |
| Protein | NP_387449, 48928048 |
| Product | F-box/WD repeat-containing protein 11 isoform A |
| RefSeq Status | REVIEWED |
| mRNA | NM_033644, 48928045 |
| Protein | NP_387448, 48928046 |
| Product | F-box/WD repeat-containing protein 11 isoform B |
| RefSeq Status | REVIEWED |
| mRNA | NM_012300, 48928049 |
| Protein | NP_036432, 48928050 |
| Product | F-box/WD repeat-containing protein 11 isoform C |
| RefSeq Status | REVIEWED |
| hsa04710 | Circadian rhythm - mammal |
| hsa04340 | Hedgehog signaling pathway |
| hsa04310 | Wnt signaling pathway |
| hsa05131 | Shigellosis |
| hsa04120 | Ubiquitin mediated proteolysis |
| hsa04114 | Oocyte meiosis |
WikiPathways
| WP231 | TNF-alpha/NF-kB Signaling Pathway |
Pathway Interaction Database
| wnt_canonical_pathway | Canonical Wnt signaling pathway |
| mtor_4pathway | mTOR signaling pathway |
| plk1_pathway | PLK1 signaling events |
| hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| ps1pathway | Presenilin action in Notch and Wnt signaling |
| Homo sapiens (human) | FBXW11 | NP_387448.2 |
| Pan troglodytes (chimpanzee) | FBXW11 | XP_518097.2 |
| Canis lupus familiaris (dog) | FBXW11 | XP_852961.1 |
| Bos taurus (cattle) | FBXW11 | XP_612428.4 |
| Mus musculus (house mouse) | Fbxw11 | NP_598776.1 |
| Rattus norvegicus (Norway rat) | Fbxw11 | XP_220281.4 |
| Gallus gallus (chicken) | FBXW11 | NP_001034351.1 |
| Danio rerio (zebrafish) | fbxw11a | NP_958467.1 |
| Danio rerio (zebrafish) | fbxw11b | NP_998669.1 |
| Caenorhabditis elegans | lin-23 | NP_495285.1 |
| ID | Name | Evidence |
| GO:0000209 | protein polyubiquitination | IDA |
| GO:0006470 | protein dephosphorylation | ISS |
| GO:0007049 | cell cycle | IEA |
| GO:0016055 | Wnt receptor signaling pathway | IEA |
| GO:0016567 | protein ubiquitination | IDA |
| GO:0016567 | protein ubiquitination | NAS |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA |
| GO:0031648 | protein destabilization | IMP |
| GO:0042753 | positive regulation of circadian rhythm | ISS |
| GO:0043161 | proteasomal ubiquitin-dependent protein catabolic process | IDA |
| GO:0045862 | positive regulation of proteolysis | IMP |
| GO:0045892 | negative regulation of transcription, DNA-dependent | IMP |
| GO:0045893 | positive regulation of transcription, DNA-dependent | ISS |
| GO:0048511 | rhythmic process | IEA |
Component
| ID | Name | Evidence |
| GO:0000151 | ubiquitin ligase complex | NAS |
| GO:0005634 | nucleus | ISS |
| GO:0005737 | cytoplasm | IEA |
| GO:0005829 | cytosol | ISS |
| GO:0019005 | SCF ubiquitin ligase complex | IDA |
Function
| ID | Name | Evidence |
| GO:0004842 | ubiquitin-protein ligase activity | IDA |
| GO:0004842 | ubiquitin-protein ligase activity | NAS |
| GO:0005515 | protein binding | IPI |
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