• THAT   AND

Sequence in raw or FASTA format:


Blast Method:


LEMD3 LEM domain containing 3 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001167614 Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_014319 Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol LEMD3
Entrez Gene ID 23592
Full Name LEM domain containing 3
Synonyms MAN1
General protein information
Preferred Names
inner nuclear membrane protein Man1
inner nuclear membrane protein Man1
LEM domain-containing protein 3
integral inner nuclear membrane protein
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009].

MIM: 607844

Osteopoikilosis, 166700 (3); Buschke-Ollendorff syndrome, 166700 (3);

mRNA Protein Product Sequence Price Select
NM_001167614, 264681409 NP_001161086, 264681410 inner nuclear membrane protein Man1 isoform 2 ORF Sequence $750.00
NM_014319, 264681408 NP_055134, 7706607 inner nuclear membrane protein Man1 isoform 1 ORF Sequence $750.00
REACT_152Cell Cycle, Mitotic
REACT_765Mitotic Prophase
REACT_910M Phase
REACT_1275Mitotic Anaphase
REACT_115566Cell Cycle
REACT_150314Mitotic Metaphase and Anaphase
REACT_160242Initiation of Nuclear Envelope Reformation
REACT_160251Clearance of Nuclear Envelope Membranes from Chromatin
REACT_160113Nuclear Envelope Reassembly
REACT_160255Nuclear Envelope Breakdown
REACT_200828Depolymerisation of the Nuclear Lamina
Homo sapiens (human)LEMD3NP_055134.2
Pan troglodytes (chimpanzee)LEMD3XP_509197.2
Macaca mulatta (Rhesus monkey)LEMD3XP_001116983.1
Canis lupus familiaris (dog)LEMD3XP_005625712.1
Bos taurus (cattle)LEMD3NP_001179628.1
Mus musculus (house mouse)Lemd3NP_001074662.2
Rattus norvegicus (Norway rat)Lemd3NP_001177929.1
Gallus gallus (chicken)LEMD3XP_416073.3
Danio rerio (zebrafish)lemd3NP_001038329.1
Xenopus (Silurana) tropicalis (western clawed frog)lemd3NP_001136130.1
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayIDA
GO:0030514negative regulation of BMP signaling pathwayIDA
GO:0032926negative regulation of activin receptor signaling pathwayIDA
GO:0035914skeletal muscle cell differentiationIEA
GO:0051726regulation of cell cycleIEA
GO:0005637nuclear inner membraneIDA
GO:0005639integral component of nuclear inner membraneIEA
GO:0016021integral component of membraneIDA
GO:0000166nucleotide bindingIEA
GO:0003677DNA bindingIEA
GO:0005515protein bindingIPI
GeneCards LEMD3
UniProt Q9Y2U8
Vega OTTHUMG00000168840
MIM 607844
Ensembl ENSG00000174106
HGNC 28887
HPRD 09704

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the LEMD3 gene?

The LEMD3 gene provides instructions for making a protein that is located in the inner membrane of the nuclear envelope. The nuclear envelope is a cell structure that surrounds the nucleus, acting as a barrier between the nucleus and the rest of the cell.

The LEMD3 protein helps control two chemical signaling pathways called the transforming growth factor beta (TGF-β) pathway and the bone morphogenic protein (BMP) pathway. Signaling through these pathways turns on (activates) proteins called Smads, which attach (bind) to specific areas of DNA to activate certain genes. The TGF-β and BMP pathways regulate various cellular processes, including cell growth and division (proliferation), the process by which cells mature to carry out special functions (differentiation), and the self-destruction of cells (apoptosis). These pathways are also involved in the growth of new bone.

The LEMD3 protein interacts with Smads to reduce signaling through the BMP and TGF-β pathways. In this way, the LEMD3 protein helps keep signaling at normal levels within the cell.


Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.