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LEMD3 LEM domain containing 3 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu04065 NM_001167614 Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu19032 NM_014319 Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu04065C NM_001167614 Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 2, mRNA. Customized vector On-demand 12-14 $329.00
OHu19032C NM_014319 Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol LEMD3
Entrez Gene ID 23592
Full Name LEM domain containing 3
Synonyms MAN1
General protein information
Preferred Names
inner nuclear membrane protein Man1
Names
inner nuclear membrane protein Man1
LEM domain-containing protein 3
integral inner nuclear membrane protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q14

Summary This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009].
Disorder

MIM: 607844

Osteopoikilosis, 166700 (3); Buschke-Ollendorff syndrome, 166700 (3);

mRNA Protein Product Sequence Price Select
NM_001167614, 264681409 NP_001161086, 264681410 inner nuclear membrane protein Man1 isoform 2 ORF Sequence $750.00
NM_014319, 264681408 NP_055134, 7706607 inner nuclear membrane protein Man1 isoform 1 ORF Sequence $750.00
Reactome
REACT_152Cell Cycle, Mitotic
REACT_765Mitotic Prophase
REACT_910M Phase
REACT_1275Mitotic Anaphase
REACT_115566Cell Cycle
REACT_150314Mitotic Metaphase and Anaphase
REACT_160242Initiation of Nuclear Envelope Reformation
REACT_160251Clearance of Nuclear Envelope Membranes from Chromatin
REACT_160113Nuclear Envelope Reassembly
REACT_160255Nuclear Envelope Breakdown
REACT_200828Depolymerisation of the Nuclear Lamina
Homo sapiens (human)LEMD3NP_055134.2
Pan troglodytes (chimpanzee)LEMD3XP_509197.2
Macaca mulatta (Rhesus monkey)LEMD3XP_001116983.1
Canis lupus familiaris (dog)LEMD3XP_005625712.1
Bos taurus (cattle)LEMD3NP_001179628.1
Mus musculus (house mouse)Lemd3NP_001074662.2
Rattus norvegicus (Norway rat)Lemd3NP_001177929.1
Gallus gallus (chicken)LEMD3XP_416073.3
Danio rerio (zebrafish)lemd3NP_001038329.1
Xenopus (Silurana) tropicalis (western clawed frog)lemd3NP_001136130.1
Process
IDNameEvidence
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayIDA
GO:0030514negative regulation of BMP signaling pathwayIDA
GO:0032926negative regulation of activin receptor signaling pathwayIDA
GO:0035914skeletal muscle cell differentiationIEA
GO:0051726regulation of cell cycleIEA
Component
IDNameEvidence
GO:0005637nuclear inner membraneIDA
GO:0005639integral component of nuclear inner membraneIEA
GO:0016020membraneTAS
GO:0016021integral component of membraneIDA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003677DNA bindingIEA
GO:0005515protein bindingIPI
GeneCards LEMD3
PDB 2CH0
UniProt Q9Y2U8
Vega OTTHUMG00000168840
MIM 607844
Ensembl ENSG00000174106
HGNC 28887
HPRD 09704

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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