Sequence in raw or FASTA format:
CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c [Homo sapiens (human)]
| Gene Symbol | CBLC |
| Entrez Gene ID | 23624 |
| Full Name | Cas-Br-M (murine) ecotropic retroviral transforming sequence c |
| Synonyms | CBL-3, CBL-SL, RNF57 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19q13.2 |
| Summary | CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999 [PubMed 10362357]).[supplied by OMIM]. |
| Disorder | MIM: 608453 |
| mRNA | NM_001130852, 195927029 |
| Protein | NP_001124324, 195927030 |
| Product | signal transduction protein CBL-C isoform 2 |
| RefSeq Status | VALIDATED |
| mRNA | NM_012116, 195927026 |
| Protein | NP_036248, 195927027 |
| Product | signal transduction protein CBL-C isoform 1 |
| RefSeq Status | VALIDATED |
| hsa04630 | Jak-STAT signaling pathway |
| hsa04120 | Ubiquitin mediated proteolysis |
| hsa05200 | Pathways in cancer |
| hsa04910 | Insulin signaling pathway |
| hsa05220 | Chronic myeloid leukemia |
| hsa04660 | T cell receptor signaling pathway |
| hsa04012 | ErbB signaling pathway |
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa04144 | Endocytosis |
WikiPathways
| WP437 | EGFR1 Signaling Pathway |
| WP481 | Insulin Signaling |
| WP673 | ErbB signaling pathway |
| Homo sapiens (human) | CBLC | NP_036248.3 |
| Canis lupus familiaris (dog) | CBLC | XP_855171.1 |
| Bos taurus (cattle) | CBLC | NP_001094718.1 |
| Mus musculus (house mouse) | Cblc | NP_075713.2 |
| Rattus norvegicus (Norway rat) | Cblc | NP_001030092.1 |
| ID | Name | Evidence |
| GO:0007166 | cell surface receptor linked signaling pathway | IEA |
| GO:0007175 | negative regulation of epidermal growth factor receptor activity | IDA |
| GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | IDA |
| GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IDA |
| GO:0043407 | negative regulation of MAP kinase activity | IDA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
Function
| ID | Name | Evidence |
| GO:0001784 | phosphotyrosine binding | IDA |
| GO:0004842 | ubiquitin-protein ligase activity | IDA |
| GO:0004871 | signal transducer activity | IEA |
| GO:0005154 | epidermal growth factor receptor binding | IDA |
| GO:0005509 | calcium ion binding | IEA |
| GO:0008270 | zinc ion binding | IEA |
| GO:0017124 | SH3 domain binding | IDA |
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