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CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001130852 Homo sapiens Cbl proto-oncogene C, E3 ubiquitin protein ligase (CBLC), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_012116 Homo sapiens Cbl proto-oncogene C, E3 ubiquitin protein ligase (CBLC), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005258696 PREDICTED: Homo sapiens Cbl proto-oncogene C, E3 ubiquitin protein ligase (CBLC), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005258697 PREDICTED: Homo sapiens Cbl proto-oncogene C, E3 ubiquitin protein ligase (CBLC), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol CBLC
Entrez Gene ID 23624
Full Name Cbl proto-oncogene C, E3 ubiquitin protein ligase
Synonyms CBL-3, CBL-SL, RNF57
General protein information
Preferred Names
signal transduction protein CBL-C
Names
signal transduction protein CBL-C
RING finger protein 57
SH3-binding protein CBL-3
SH3-binding protein CBL-C
Cbl proto-oncogene, E3 ubiquitin protein ligase C
Cas-Br-M (murine) ectropic retroviral transforming sequence c
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.2

Summary This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].
Disorder

MIM: 608453

mRNA Protein Product Sequence Price Select
NM_001130852, 195927029 NP_001124324, 195927030 E3 ubiquitin-protein ligase CBL-C isoform 2 ORF Sequence $550.00
NM_012116, 195927026 NP_036248, 195927027 E3 ubiquitin-protein ligase CBL-C isoform 1 ORF Sequence $550.00
XM_005258696, 530416086 XP_005258753, 530416087 E3 ubiquitin-protein ligase CBL-C isoform X1 ORF Sequence $550.00
XM_005258697, 530416088 XP_005258754, 530416089 E3 ubiquitin-protein ligase CBL-C isoform X2 ORF Sequence $400.00
KEGG
hsa04012ErbB signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04910Insulin signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04660T cell receptor signaling pathway
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
hsa04144Endocytosis
hsa05100Bacterial invasion of epithelial cells
hsa05205Proteoglycans in cancer
WikiPathways
WP437EGFR1 Signaling Pathway
WP481Insulin Signaling
WP673ErbB signaling pathway
Homo sapiens (human)CBLCNP_036248.3
Pan troglodytes (chimpanzee)CBLCXP_003954528.1
Macaca mulatta (Rhesus monkey)CBLCXP_001109370.1
Canis lupus familiaris (dog)CBLCXP_005616520.1
Bos taurus (cattle)CBLCNP_001094718.1
Mus musculus (house mouse)CblcNP_075713.3
Rattus norvegicus (Norway rat)CblcNP_001030092.1
Process
IDNameEvidence
GO:0007166cell surface receptor signaling pathwayIEA
GO:0007175negative regulation of epidermal growth factor-activated receptor activityIDA
GO:0042059negative regulation of epidermal growth factor receptor signaling pathwayIDA
GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic processIDA
GO:0043407negative regulation of MAP kinase activityIDA
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0001784phosphotyrosine bindingIDA
GO:0004842ubiquitin-protein transferase activityIDA
GO:0004871signal transducer activityIEA
GO:0005154epidermal growth factor receptor bindingIDA
GO:0005509calcium ion bindingIEA
GO:0008270zinc ion bindingIEA
GO:0016874ligase activityIEA
GO:0017124SH3 domain bindingIDA
GeneCards CBLC
UniProt Q9ULV8
Vega OTTHUMG00000150715
MIM 608453
Ensembl ENSG00000142273
HGNC 15961
HPRD 09765

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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