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Klrk1 killer cell lectin-like receptor subfamily K, member 1 [Rattus norvegicus (Norway rat)]


RefSeq Accession Definition Sequence Price Select
NM_133512 Rattus norvegicus killer cell lectin-like receptor subfamily K, member 1 (Klrk1), mRNA. Full Length $327.99
ORF Sequence $187.92


Gene Symbol Klrk1
Entrez Gene ID 24934
Full Name killer cell lectin-like receptor subfamily K, member 1
Synonyms NKG2D, Nkrp2
Gene Type protein-coding
Organism Rattus norvegicus (Norway rat)
Genome

4

4q42
Summary functions as a natural cytotoxicity receptor to stimulate perforin-mediated elimination of ligand-expressing tumor cells [RGD].
Disorder

MIM:

mRNA NM_133512, 19424149
Protein NP_598196, 19424150
Product NKG2-D type II integral membrane protein
RefSeq Status PROVISIONAL
KEGG
rno05144Malaria
rno04650Natural killer cell mediated cytotoxicity
Homo sapiens (human)KLRK1NP_031386.2
Pan troglodytes (chimpanzee)KLRK1NP_001009059.1
Canis lupus familiaris (dog)KLRK1XP_854106.1
Bos taurus (cattle)KLRK1NP_001068607.1
Mus musculus (house mouse)Klrk1NP_149069.1
Rattus norvegicus (Norway rat)Klrk1NP_598196.1
Process
IDNameEvidence
GO:0002223stimulatory C-type lectin receptor signaling pathwayIEA
GO:0002223stimulatory C-type lectin receptor signaling pathwayISO
GO:0030101natural killer cell activationIEA
GO:0030101natural killer cell activationISO
GO:0032729positive regulation of interferon-gamma productionIEA
GO:0032729positive regulation of interferon-gamma productionISO
GO:0045429positive regulation of nitric oxide biosynthetic processIEA
GO:0045429positive regulation of nitric oxide biosynthetic processISO
GO:0045954positive regulation of natural killer cell mediated cytotoxicityIEA
GO:0045954positive regulation of natural killer cell mediated cytotoxicityISO
GO:0050830defense response to Gram-positive bacteriumIEA
GO:0050830defense response to Gram-positive bacteriumISO
GO:0071222cellular response to lipopolysaccharideIEA
GO:0071222cellular response to lipopolysaccharideISO
Component
IDNameEvidence
GO:0009897external side of plasma membraneIEA
GO:0009897external side of plasma membraneISO
GO:0009986cell surfaceISO
GO:0016020membraneIEA
GO:0016021integral to membraneIEA
Function
IDNameEvidence
GO:0004872receptor activityIEA
GO:0005488bindingIEA
GO:0005529sugar bindingIEA
GO:0032394MHC class Ib receptor activityIEA
GO:0032394MHC class Ib receptor activityISO
GO:0042288MHC class I protein bindingIEA
GO:0042288MHC class I protein bindingISO
GO:0042803protein homodimerization activityISO
GO:0045233natural killer cell receptor activityIDA
GeneCards Klrk1
UniProt O70215
RGD 3180
Ensembl ENSRNOG00000009638

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