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G6PC glucose-6-phosphatase, catalytic subunit [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000151 Homo sapiens glucose-6-phosphatase, catalytic subunit (G6PC), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001270397 Homo sapiens glucose-6-phosphatase, catalytic subunit (G6PC), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Gene Symbol G6PC
Entrez Gene ID 2538
Full Name glucose-6-phosphatase, catalytic subunit
Synonyms G6PC1, G6PT, GSD1, GSD1a
General protein information
Preferred Names
glucose-6-phosphatase
Names
glucose-6-phosphatase
G6Pase
G-6-Pase
G6Pase-alpha
glucose-6-phosphatase alpha
NP_000142.1
NP_000142.2
NP_001257326.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21

Summary Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011].
Disorder

MIM: 613742

mRNA Protein Product Sequence Price Select
NM_000151, 393537030 NP_000142, 393537031 glucose-6-phosphatase isoform 1 ORF Sequence $269.00
NM_001270397, 393537071 NP_001257326, 393537072 glucose-6-phosphatase isoform 2 ORF Sequence $250.00
KEGG
hsa00052Galactose metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00500Starch and sucrose metabolism
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04973Carbohydrate digestion and absorption
hsa04151PI3K-Akt signaling pathway
hsa04068FoxO signaling pathway
hsa04152AMPK signaling pathway
WikiPathways
WP534Glycolysis and Gluconeogenesis
WP710DNA damage response (only ATM dependent)
WP706SIDS Susceptibility Pathways
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
foxopathwayFoxO family signaling
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_212Glucose transport
REACT_9441Hexose transport
REACT_474Metabolism of carbohydrates
REACT_15518Transmembrane transport of small molecules
REACT_111217Metabolism
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)G6PCNP_000142.2
Pan troglodytes (chimpanzee)G6PCXP_003315515.1
Macaca mulatta (Rhesus monkey)G6PCXP_001112333.1
Canis lupus familiaris (dog)G6PCNP_001002993.1
Bos taurus (cattle)G6PCNP_001069592.1
Mus musculus (house mouse)G6pcNP_032087.2
Rattus norvegicus (Norway rat)G6pcNP_037230.2
Gallus gallus (chicken)LOC100857298XP_003642865.1
Danio rerio (zebrafish)g6pca.2NP_001157278.1
Xenopus (Silurana) tropicalis (western clawed frog)g6pc2NP_001096531.1
Xenopus (Silurana) tropicalis (western clawed frog)g6pcNP_001005682.1
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:0005977glycogen metabolic processTAS
GO:0005980glycogen catabolic processIEA
GO:0006094gluconeogenesisIEA
GO:0006094gluconeogenesisIMP
GO:0006641triglyceride metabolic processIEA
GO:0008202steroid metabolic processIEA
GO:0008645hexose transportTAS
GO:0010468regulation of gene expressionIEA
GO:0015758glucose transportTAS
GO:0015760glucose-6-phosphate transportIEA
GO:0016311dephosphorylationIDA
GO:0016311dephosphorylationIEA
GO:0035264multicellular organism growthIEA
GO:0042593glucose homeostasisIMP
GO:0042632cholesterol homeostasisIEA
GO:0044281small molecule metabolic processTAS
GO:0046415urate metabolic processIEA
GO:0051156glucose 6-phosphate metabolic processIEA
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005789endoplasmic reticulum membraneTAS
GO:0016021integral component of membraneIDA
GO:0030176integral component of endoplasmic reticulum membraneTAS
Function
IDNameEvidence
GO:0004346glucose-6-phosphatase activityIDA
GO:0016773phosphotransferase activity, alcohol group as acceptorIEA
GO:0042301phosphate ion bindingIMP
GeneCards G6PC
UniProt P35575
MIM 613742
HGNC 4056
HPRD 01983

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the G6PC gene?

The G6PC gene provides instructions for making an enzyme called glucose 6-phosphatase. This enzyme is found on the membrane of the endoplasmic reticulum, which is a structure inside cells that is involved in protein processing and transport. Glucose 6-phosphatase works together with the glucose 6-phosphate translocase protein (produced from the SLC37A4 gene) to break down a type of sugar molecule called glucose 6-phosphate. The breakdown of this molecule produces the simple sugar glucose, which is the primary source of energy for most cells in the body. The glucose 6-phosphatase enzyme is expressed (active) in the liver, kidneys, and intestines, and is the main regulator of glucose production in the liver.

Interactant

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