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Sequence in raw or FASTA format:

Database:

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G6PC glucose-6-phosphatase, catalytic subunit [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000151 Homo sapiens glucose-6-phosphatase, catalytic subunit (G6PC), transcript variant 1, mRNA. ORF Sequence $311.46
Peptide Services
Antibody Services
Protein Services
NM_001270397 Homo sapiens glucose-6-phosphatase, catalytic subunit (G6PC), transcript variant 2, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services


Gene Symbol G6PC
Entrez Gene ID 2538
Full Name glucose-6-phosphatase, catalytic subunit
Synonyms G6PC1, G6PT, GSD1, GSD1a, MGC163350
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21

Summary Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011].
Disorder

MIM: 613742

mRNA Protein Product Sequence Price Select
NM_000151, 393537030 NP_000142, 393537031 glucose-6-phosphatase isoform 1 Full Length $1459.15
ORF Sequence $311.46
NM_001270397, 393537071 NP_001257326, 393537072 glucose-6-phosphatase isoform 2 Full Length $1432.20
ORF Sequence $159.00
KEGG
hsa04973Carbohydrate digestion and absorption
hsa04920Adipocytokine signaling pathway
hsa00052Galactose metabolism
hsa00500Starch and sucrose metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa04910Insulin signaling pathway
hsa04151PI3K-Akt signaling pathway
WikiPathways
WP710DNA damage response (only ATM dependent)
WP706SIDS Susceptibility Pathways
WP534Glycolysis and Gluconeogenesis
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
foxopathwayFoxO family signaling
Reactome
REACT_9441Hexose transport
REACT_212Glucose transport
REACT_19118SLC-mediated transmembrane transport
REACT_15518Transmembrane transport of small molecules
REACT_474Metabolism of carbohydrates
REACT_111217Metabolism
Homo sapiens (human)G6PCNP_000142.2
Pan troglodytes (chimpanzee)G6PCXP_003315515.1
Macaca mulatta (Rhesus monkey)G6PCXP_001112333.1
Canis lupus familiaris (dog)G6PCNP_001002993.1
Bos taurus (cattle)G6PCNP_001069592.1
Mus musculus (house mouse)G6pcNP_032087.2
Rattus norvegicus (Norway rat)G6pcNP_037230.2
Gallus gallus (chicken)LOC100857298XP_003642865.1
Danio rerio (zebrafish)g6pca.2NP_001157278.1
Drosophila melanogaster (fruit fly)CG15400NP_001097063.1
GeneCards G6PC
UniProt K7EL82, P35575, B4E1C3
MIM 613742
Ensembl ENSG00000131482
HGNC 4056
HPRD 01983

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
glucose-6-phosphatase
Names
glucose-6-phosphatase
G6Pase
G-6-Pase
G6Pase-alpha
glucose-6-phosphatase alpha
NP_000142.1
NP_000142.2
NP_001257326.1

Interactant

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