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GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26115 NM_001127645 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), transcript variant 4, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu26115 NM_001127643 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu26115 NM_001127648 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), transcript variant 7, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu26115 NM_000806 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu26115 NM_001127644 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu26115C NM_001127645 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), transcript variant 4, mRNA. Customized vector In-stock 5-7 $149.00
OHu26115C NM_001127643 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu26115C NM_001127648 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), transcript variant 7, mRNA. Customized vector In-stock 5-7 $149.00
OHu26115C NM_000806 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu26115C NM_001127644 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol GABRA1
Entrez Gene ID 2554
Full Name gamma-aminobutyric acid (GABA) A receptor, alpha 1
Synonyms ECA4, EIEE19, EJM, EJM5
General protein information
Preferred Names
gamma-aminobutyric acid receptor subunit alpha-1
Names
gamma-aminobutyric acid receptor subunit alpha-1
GABA(A) receptor, alpha 1
GABA(A) receptor subunit alpha-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q34

Summary This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 137160

{Epilepsy, juvenile myoclonic, susceptibility to, 5}, 611136 (3);

mRNA Protein Product Sequence Price Select
NM_000806, 189083722 NP_000797, 38327554 gamma-aminobutyric acid receptor subunit alpha-1 precursor ORF Sequence $360.00
NM_001127643, 189083723 NP_001121115, 189083724 gamma-aminobutyric acid receptor subunit alpha-1 precursor ORF Sequence $360.00
NM_001127644, 189083725 NP_001121116, 189083726 gamma-aminobutyric acid receptor subunit alpha-1 precursor ORF Sequence $360.00
NM_001127645, 189083727 NP_001121117, 189083728 gamma-aminobutyric acid receptor subunit alpha-1 precursor ORF Sequence $360.00
NM_001127648, 189083733 NP_001121120, 189083734 gamma-aminobutyric acid receptor subunit alpha-1 precursor ORF Sequence $360.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa04727GABAergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa05033Nicotine addiction
hsa05032Morphine addiction
WikiPathways
WP706SIDS Susceptibility Pathways
Reactome
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_15518Transmembrane transport of small molecules
REACT_13477Transmission across Chemical Synapses
REACT_13685Neuronal System
REACT_24987GABA A receptor activation
REACT_25199GABA receptor activation
REACT_25300Ion channel transport
REACT_25387Ligand-gated ion channel transport
Homo sapiens (human)GABRA1NP_000797.2
Pan troglodytes (chimpanzee)GABRA1XP_001144644.2
Macaca mulatta (Rhesus monkey)GABRA1XP_002804660.1
Canis lupus familiaris (dog)LOC489143XP_546261.2
Bos taurus (cattle)GABRA1NP_001178048.1
Mus musculus (house mouse)Gabra1NP_034380.1
Rattus norvegicus (Norway rat)Gabra1NP_899155.1
Gallus gallus (chicken)GABRA1NP_989649.1
Danio rerio (zebrafish)gabra1NP_001070794.1
Xenopus (Silurana) tropicalis (western clawed frog)gabra1XP_002941682.2
Process
IDNameEvidence
GO:0006810transportTAS
GO:0007214gamma-aminobutyric acid signaling pathwayIEA
GO:0007268synaptic transmissionTAS
GO:0034220ion transmembrane transportTAS
GO:0051932synaptic transmission, GABAergicISS
GO:0055085transmembrane transportTAS
GO:1902476chloride transmembrane transportIEA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneISS
GO:0030054cell junctionIEA
GO:0034707chloride channel complexIEA
GO:0045211postsynaptic membraneIEA
Function
IDNameEvidence
GO:0004890GABA-A receptor activityIEA
GO:0005230extracellular ligand-gated ion channel activityIEA
GO:0005254chloride channel activityIEA
GO:0008144drug bindingISS
GO:0016917GABA receptor activityISS
GeneCards GABRA1
UniProt P14867, A8K177
Vega OTTHUMG00000163586
MIM 137160
Ensembl ENSG00000022355
HGNC 4075
HPRD 00662

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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