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CHMP2B charged multivesicular body protein 2B [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18244 NM_014043 Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu18651 NM_001244644 Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu18244C NM_014043 Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant 1, mRNA. Customized vector On-demand 7-9 $209.00
OHu18651C NM_001244644 Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol CHMP2B
Entrez Gene ID 25978
Full Name charged multivesicular body protein 2B
Synonyms ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B
General protein information
Preferred Names
charged multivesicular body protein 2b
Names
charged multivesicular body protein 2b
VPS2 homolog B
chromatin modifying protein 2B
vacuolar protein-sorting-associated protein 2-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p11.2

Summary This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008].
Disorder

MIM: 609512

Dementia, familial, nonspecific, 600795 (3); Amyotrophic lateral

mRNA Protein Product Sequence Price Select
NM_001244644, 347582618 NP_001231573, 347582619 charged multivesicular body protein 2b isoform 2 ORF Sequence $250.00
NM_014043, 170650589 NP_054762, 40254866 charged multivesicular body protein 2b isoform 1 ORF Sequence $250.00
KEGG
hsa04144Endocytosis
hsa_M00412ESCRT-III complex
Reactome
REACT_6256HIV Life Cycle
REACT_6359Budding and maturation of HIV virion
REACT_6185HIV Infection
REACT_6361Late Phase of HIV Life Cycle
REACT_11123Membrane Trafficking
REACT_27258Endosomal Sorting Complex Required For Transport (ESCRT)
REACT_116125Disease
Homo sapiens (human)CHMP2BNP_054762.2
Pan troglodytes (chimpanzee)CHMP2BXP_003950194.1
Macaca mulatta (Rhesus monkey)CHMP2BXP_001104518.1
Canis lupus familiaris (dog)CHMP2BXP_544799.3
Bos taurus (cattle)CHMP2BNP_001030549.1
Mus musculus (house mouse)Chmp2bNP_081155.1
Rattus norvegicus (Norway rat)Chmp2bXP_343996.5
Gallus gallus (chicken)CHMP2BNP_001025963.1
Danio rerio (zebrafish)chmp2bbNP_998069.1
Drosophila melanogaster (fruit fly)CHMP2BNP_647947.1
Caenorhabditis elegansC01A2.4NP_493357.2
Arabidopsis thaliana (thale cress)VPS2.3NP_563696.1
Xenopus (Silurana) tropicalis (western clawed frog)chmp2bNP_998866.1
Process
IDNameEvidence
GO:0008219cell deathIEA
GO:0015031protein transportIEA
GO:0016032viral processTAS
GO:0016197endosomal transportTAS
GO:0019058viral life cycleTAS
GO:0061024membrane organizationTAS
Component
IDNameEvidence
GO:0005622intracellularIDA
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005739mitochondrionIDA
GO:0005829cytosolTAS
GO:0031902late endosome membraneIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0019904protein domain specific bindingIPI
GeneCards CHMP2B
UniProt Q9UQN3, B2RE76
Vega OTTHUMG00000158982
MIM 609512
Ensembl ENSG00000083937
HGNC 24537
HPRD 13174

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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