Sequence in raw or FASTA format:
CHMP2B charged multivesicular body protein 2B [Homo sapiens (human)]
|Entrez Gene ID||25978|
|Full Name||charged multivesicular body protein 2B|
|Synonyms||ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008].|
Dementia, familial, nonspecific, 600795 (3); Amyotrophic lateral
|REACT_6256||HIV Life Cycle|
|REACT_6359||Budding and maturation of HIV virion|
|REACT_6361||Late Phase of HIV Life Cycle|
|REACT_27258||Endosomal Sorting Complex Required For Transport (ESCRT)|
|Homo sapiens (human)||CHMP2B||NP_054762.2|
|Pan troglodytes (chimpanzee)||CHMP2B||XP_003950194.1|
|Macaca mulatta (Rhesus monkey)||CHMP2B||XP_001104518.1|
|Canis lupus familiaris (dog)||CHMP2B||XP_544799.3|
|Bos taurus (cattle)||CHMP2B||NP_001030549.1|
|Mus musculus (house mouse)||Chmp2b||NP_081155.1|
|Rattus norvegicus (Norway rat)||Chmp2b||XP_343996.5|
|Gallus gallus (chicken)||CHMP2B||NP_001025963.1|
|Danio rerio (zebrafish)||chmp2bb||NP_998069.1|
|Drosophila melanogaster (fruit fly)||CHMP2B||NP_647947.1|
|Arabidopsis thaliana (thale cress)||VPS2.3||NP_563696.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||chmp2b||NP_998866.1|
|GO:0019058||viral life cycle||TAS|
|GO:0031902||late endosome membrane||IEA|
|GO:0070062||extracellular vesicular exosome||IDA|
|GO:0019904||protein domain specific binding||IPI|
What is the normal function of the CHMP2B gene?
The CHMP2B gene provides instructions for making a protein called charged multivesicular body protein 2B. This protein is active in the brain, where it appears to be essential for the survival of nerve cells (neurons).
Charged multivesicular body protein 2B forms one part (subunit) of a group of proteins known as the ESCRT-III complex. This complex helps transport other proteins from the cell membrane to the interior of the cell, a process known as endocytosis. In particular, the ESCRT-III complex is involved in the endocytosis of proteins that need to be broken down (degraded) by the cell. The complex helps sort these proteins into structures called multivesicular bodies (MVBs), which deliver them to lysosomes. Lysosomes are compartments within cells that digest and recycle many different types of molecules.
Charged multivesicular body protein 2B is regulated by a segment at one end of the protein known as the C-terminal domain. This domain usually keeps the protein turned off (inactive). The inactive protein is unable to interact with other subunits of the ESCRT-III complex, which prevents the complex from forming when it is not needed. The C-terminal domain also plays an important role in disassembling the ESCRT-III complex through its interaction with a protein called vacuolar protein sorting 4 (Vps4).
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