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CHMP2B chromatin modifying protein 2B [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001244644 Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_014043 Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Gene Symbol CHMP2B
Entrez Gene ID 25978
Full Name chromatin modifying protein 2B
Synonyms CHMP2.5, DKFZp564O123, DMT1, VPS2-2, VPS2B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p11.2

Summary This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008].
Disorder

MIM: 609512

Dementia, familial, nonspecific, 600795 (3); Amyotrophic lateral

mRNA Protein Product Sequence Price Select
NM_001244644, 347582618 NP_001231573, 347582619 charged multivesicular body protein 2b isoform 2 ORF Sequence $250.00
NM_014043, 170650589 NP_054762, 40254866 charged multivesicular body protein 2b isoform 1 ORF Sequence $250.00
KEGG
hsa_M00412ESCRT-III complex
hsa04144Endocytosis
Reactome
REACT_27258Endosomal Sorting Complex Required For Transport (ESCRT)
REACT_11123Membrane Trafficking
Homo sapiens (human)CHMP2BNP_054762.2
Macaca mulatta (Rhesus monkey)CHMP2BXP_001104518.1
Canis lupus familiaris (dog)CHMP2BXP_544799.3
Bos taurus (cattle)CHMP2BNP_001030549.1
Mus musculus (house mouse)Chmp2bNP_081155.1
Gallus gallus (chicken)CHMP2BNP_001025963.1
Danio rerio (zebrafish)LOC569532NP_001116769.1
Drosophila melanogaster (fruit fly)CHMP2BNP_647947.1
Caenorhabditis elegansC01A2.4NP_493357.2
Arabidopsis thaliana (thale cress)VPS2.3NP_563696.1
GeneCards CHMP2B
PDB 2JQK
UniProt Q9UQN3, B2RE76
MIM 609512
Ensembl ENSG00000083937
HGNC 24537
HPRD 13174

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
charged multivesicular body protein 2b
Names
charged multivesicular body protein 2b
VPS2 homolog B
chromatin modifying protein 2B
vacuolar protein-sorting-associated protein 2-2

Interactant



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