HACL1 2-hydroxyacyl-CoA lyase 1 [Homo sapiens (human)]
| Gene Symbol | HACL1 |
| Entrez Gene ID | 26061 |
| Full Name | 2-hydroxyacyl-CoA lyase 1 |
| Synonyms | 2-HPCL, FLJ55041, HPCL, HPCL2, PHYH2 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
3 3p25.1 |
| Summary | |
| Disorder | MIM: 604300 |
| mRNA | NM_012260, 93004077 |
| Protein | NP_036392, 93004078 |
| Product | 2-hydroxyacyl-CoA lyase 1 |
| RefSeq Status | VALIDATED |
| hsa04146 | Peroxisome |
Reactome
| REACT_17003 | Alpha-oxidation of phytanate |
| REACT_22258 | Metabolism of lipids and lipoproteins |
| REACT_16957 | Peroxisomal lipid metabolism |
| Homo sapiens (human) | HACL1 | NP_036392.2 |
| Pan troglodytes (chimpanzee) | HACL1 | XP_001160528.1 |
| Canis lupus familiaris (dog) | HACL1 | XP_534256.2 |
| Bos taurus (cattle) | HACL1 | NP_001092419.1 |
| Mus musculus (house mouse) | Hacl1 | NP_064359.2 |
| Rattus norvegicus (Norway rat) | Hacl1 | NP_445945.1 |
| Gallus gallus (chicken) | HACL1 | XP_418737.2 |
| Danio rerio (zebrafish) | hacl1 | NP_998250.1 |
| Drosophila melanogaster (fruit fly) | CG11208 | NP_611460.1 |
| Caenorhabditis elegans | B0334.3 | NP_496455.1 |
| Arabidopsis thaliana (thale cress) | AT5G17380 | NP_197240.1 |
| ID | Name | Evidence |
| GO:0001561 | fatty acid alpha-oxidation | IDA |
| GO:0001561 | fatty acid alpha-oxidation | TAS |
| GO:0044255 | cellular lipid metabolic process | EXP |
Component
| ID | Name | Evidence |
| GO:0005777 | peroxisome | IDA |
| GO:0005782 | peroxisomal matrix | TAS |
Function
| ID | Name | Evidence |
| GO:0000287 | magnesium ion binding | IEA |
| GO:0016830 | carbon-carbon lyase activity | IDA |
| GO:0016830 | carbon-carbon lyase activity | TAS |
| GO:0030976 | thiamine pyrophosphate binding | IDA |
| GO:0042802 | identical protein binding | IPI |
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