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PLA2G2D phospholipase A2, group IID [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu09864 NM_001271814 Homo sapiens phospholipase A2, group IID (PLA2G2D), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu10091 NM_012400 Homo sapiens phospholipase A2, group IID (PLA2G2D), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu09864C NM_001271814 Homo sapiens phospholipase A2, group IID (PLA2G2D), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu10091C NM_012400 Homo sapiens phospholipase A2, group IID (PLA2G2D), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol PLA2G2D
Entrez Gene ID 26279
Full Name phospholipase A2, group IID
Synonyms PLA2IID, SPLASH, sPLA2-IID, sPLA2S
General protein information
Preferred Names
group IID secretory phospholipase A2
Names
group IID secretory phospholipase A2
GIID sPLA2
secretory phospholipase A2s
phosphatidylcholine 2-acylhydrolase 2D
secretory-type PLA, stroma-associated homolog
NP_036532.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36.12

Summary This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012].
Disorder

MIM: 605630

mRNA Protein Product Sequence Price Select
NM_001271814, 425854811 NP_001258743, 425854812 group IID secretory phospholipase A2 isoform 2 precursor ORF Sequence $150.00
NM_012400, 425854810 NP_036532, 6912596 group IID secretory phospholipase A2 isoform 1 precursor ORF Sequence $99.00
KEGG
hsa00565Ether lipid metabolism
hsa00591Linoleic acid metabolism
hsa00590Arachidonic acid metabolism
hsa00592alpha-Linolenic acid metabolism
hsa00564Glycerophospholipid metabolism
hsa04270Vascular smooth muscle contraction
hsa04972Pancreatic secretion
hsa04975Fat digestion and absorption
hsa04014Ras signaling pathway
Reactome
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_121369Acyl chain remodelling of PE
REACT_121401Glycerophospholipid biosynthesis
REACT_120870Phospholipid metabolism
REACT_121384Acyl chain remodelling of PS
REACT_120906Synthesis of PA
REACT_120829Acyl chain remodelling of PC
REACT_121324Acyl chain remodelling of PG
REACT_120722Acyl chain remodelling of PI
Homo sapiens (human)PLA2G2DNP_036532.1
Pan troglodytes (chimpanzee)PLA2G2DXP_524585.3
Macaca mulatta (Rhesus monkey)PLA2G2DXP_001095528.1
Canis lupus familiaris (dog)PLA2G2DXP_544524.3
Mus musculus (house mouse)Pla2g2dNP_035239.1
Rattus norvegicus (Norway rat)Pla2g2dNP_001013446.1
Process
IDNameEvidence
GO:0006644phospholipid metabolic processTAS
GO:0006654phosphatidic acid biosynthetic processTAS
GO:0006954inflammatory responseTAS
GO:0016042lipid catabolic processIEA
GO:0036148phosphatidylglycerol acyl-chain remodelingTAS
GO:0036149phosphatidylinositol acyl-chain remodelingTAS
GO:0036150phosphatidylserine acyl-chain remodelingTAS
GO:0036151phosphatidylcholine acyl-chain remodelingTAS
GO:0036152phosphatidylethanolamine acyl-chain remodelingTAS
GO:0044281small molecule metabolic processTAS
GO:0046474glycerophospholipid biosynthetic processTAS
Component
IDNameEvidence
GO:0005576extracellular regionTAS
Function
IDNameEvidence
GO:0004623phospholipase A2 activityIEA
GO:0005509calcium ion bindingIEA
GeneCards PLA2G2D
UniProt Q9UNK4
MIM 605630
HGNC 9033
HPRD 07546

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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