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AATF apoptosis antagonizing transcription factor [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_012138 Homo sapiens apoptosis antagonizing transcription factor (AATF), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Related Services

Gene Symbol AATF
Entrez Gene ID 26574
Full Name apoptosis antagonizing transcription factor
Synonyms BFR2, CHE-1, CHE1, DED
General protein information
Preferred Names
protein AATF
Names
protein AATF
rb-binding protein Che-1
apoptosis-antagonizing transcription factor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q12

Summary The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008].
Disorder

MIM: 608463

mRNA Protein Product Sequence Price Select
NM_012138, 76159274 NP_036270, 7657013 protein AATF ORF Sequence $360.00
Pathway Interaction Database
rb_1pathwayRegulation of retinoblastoma protein
Reactome
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_11061Signalling by NGF
REACT_13776p75 NTR receptor-mediated signalling
REACT_13638NRAGE signals death through JNK
REACT_111102Signal Transduction
Homo sapiens (human)AATFNP_036270.1
Pan troglodytes (chimpanzee)AATFXP_511427.2
Macaca mulatta (Rhesus monkey)AATFXP_001109240.2
Canis lupus familiaris (dog)AATFXP_005624830.1
Bos taurus (cattle)AATFXP_002695664.3
Mus musculus (house mouse)AatfNP_062790.1
Rattus norvegicus (Norway rat)AatfNP_446172.1
Gallus gallus (chicken)AATFNP_001025895.1
Danio rerio (zebrafish)aatfNP_001258768.1
Caenorhabditis elegansY73E7A.2NP_490870.2
Arabidopsis thaliana (thale cress)AT5G61330NP_200941.2
Xenopus (Silurana) tropicalis (western clawed frog)aatfNP_001016308.1
Process
IDNameEvidence
GO:0006974cellular response to DNA damage stimulusIEP
GO:0007155cell adhesionIEA
GO:0007346regulation of mitotic cell cycleIEA
GO:0032929negative regulation of superoxide anion generationIDA
GO:0040016embryonic cleavageIEA
GO:0042254ribosome biogenesisIEA
GO:0042985negative regulation of amyloid precursor protein biosynthetic processIEA
GO:0043065positive regulation of apoptotic processTAS
GO:0043066negative regulation of apoptotic processIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0097190apoptotic signaling pathwayTAS
GO:2000378negative regulation of reactive oxygen species metabolic processIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005794Golgi apparatusIEA
GO:0005813centrosomeIDA
GO:0005925focal adhesionIDA
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0005515protein bindingIPI
GO:0043522leucine zipper domain bindingIPI
GO:0044822poly(A) RNA bindingIDA
GO:0048156tau protein bindingIEA
GeneCards AATF
UniProt Q9NY61
Vega OTTHUMG00000179145
MIM 608463
Ensembl ENSG00000108270
HGNC 19235
HPRD 12236

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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