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AATF apoptosis antagonizing transcription factor [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_012138 Homo sapiens apoptosis antagonizing transcription factor (AATF), mRNA. ORF Sequence $488.07
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Gene Symbol AATF
Entrez Gene ID 26574
Full Name apoptosis antagonizing transcription factor
Synonyms CHE-1, CHE1, DED
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q12

Summary The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008].
Disorder

MIM: 608463

mRNA Protein Product Sequence Price Select
NM_012138, 76159274 NP_036270, 7657013 protein AATF Full Length $629.88
ORF Sequence $488.07
Pathway Interaction Database
rb_1pathwayRegulation of retinoblastoma protein
Reactome
REACT_111102Signal Transduction
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_13638NRAGE signals death through JNK
REACT_11061Signalling by NGF
REACT_13776p75 NTR receptor-mediated signalling
Homo sapiens (human)AATFNP_036270.1
Pan troglodytes (chimpanzee)AATFXP_511427.2
Macaca mulatta (Rhesus monkey)AATFXP_001109240.2
Canis lupus familiaris (dog)LOC100856664XP_003639348.1
Bos taurus (cattle)AATFXP_002695664.2
Mus musculus (house mouse)AatfNP_062790.1
Rattus norvegicus (Norway rat)AatfNP_446172.1
Gallus gallus (chicken)AATFNP_001025895.1
Danio rerio (zebrafish)aatfNP_001077297.2
Drosophila melanogaster (fruit fly)CG11188NP_609066.1
Caenorhabditis elegansY73E7A.2NP_490870.2
Arabidopsis thaliana (thale cress)AT5G61330NP_200941.2
GeneCards AATF
UniProt Q9NY61
MIM 608463
Ensembl ENSG00000108270
HGNC 19235
HPRD 12236

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
protein AATF
Names
protein AATF
rb-binding protein Che-1
apoptosis-antagonizing transcription factor

Interactant

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