AATF apoptosis antagonizing transcription factor [Homo sapiens (human)]

Gene Symbol	AATF
Entrez Gene ID	26574
Full Name	apoptosis antagonizing transcription factor
Synonyms	CHE-1, CHE1, DED
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:17 Map Location:17q12
Summary	The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq].
Disorder	MIM: 608463

Pathway Interaction Database

rb_1pathway

Regulation of retinoblastoma protein

Reactome

REACT_13638	NRAGE signals death through JNK
REACT_11061	Signalling by NGF
REACT_13776	p75 NTR receptor-mediated signalling
REACT_13720	Cell death signalling via NRAGE, NRIF and NADE

Homo sapiens (human)	AATF	NP_036270.1
Pan troglodytes (chimpanzee)	AATF	XP_511427.2
Canis lupus familiaris (dog)	AATF	XP_537715.2
Bos taurus (cattle)	AATF	XP_001252958.2
Mus musculus (house mouse)	Aatf	NP_062790.1
Rattus norvegicus (Norway rat)	Aatf	NP_446172.1
Gallus gallus (chicken)	AATF	NP_001025895.1
Danio rerio (zebrafish)	aatf	NP_001077297.2
Drosophila melanogaster (fruit fly)	CG11188	NP_609066.1
Caenorhabditis elegans	Y73E7A.2	NP_490870.2
Arabidopsis thaliana (thale cress)	AT5G61330	NP_200941.2

Process

ID	Name	Evidence
GO:0006351	transcription, DNA-dependent	IDA
GO:0006915	apoptosis	EXP
GO:0006916	anti-apoptosis	IMP
GO:0006974	response to DNA damage stimulus	IEP
GO:0007155	cell adhesion	IEA
GO:0007346	regulation of mitotic cell cycle	IEA
GO:0008624	induction of apoptosis by extracellular signals	EXP
GO:0032929	negative regulation of superoxide anion generation	IDA
GO:0040016	embryonic cleavage	IEA
GO:0042254	ribosome biogenesis	IEA
GO:0042985	negative regulation of amyloid precursor protein biosynthetic process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA
GO:0048011	nerve growth factor receptor signaling pathway	TAS
GO:2000378	negative regulation of reactive oxygen species metabolic process	IDA

Component

Function

ID	Name	Evidence
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA
GO:0005515	protein binding	IPI
GO:0019904	protein domain specific binding	IEA
GO:0043522	leucine zipper domain binding	IPI
GO:0048156	tau protein binding	IEA

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RefSeq Accession	Definition	Sequence	Price	Select
NM_012138	Homo sapiens apoptosis antagonizing transcription factor (AATF), mRNA.	Full Length	$629.88
NM_012138		ORF Sequence	$488.07