ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 [Homo sapiens (human)]
| Gene Symbol | ABL2 |
| Entrez Gene ID | 27 |
| Full Name | v-abl Abelson murine leukemia viral oncogene homolog 2 |
| Synonyms | ABLL, ARG, FLJ22224, FLJ31718, FLJ41441 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1q25.2 |
| Summary | This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: 164690 Leukemia, acute myeloid, with eosinophilia (1) |
| mRNA | NM_001136001, 209862777 |
| Protein | NP_001129473, 209862778 |
| Product | tyrosine-protein kinase ABL2 isoform e |
| RefSeq Status | REVIEWED |
| mRNA | NM_007314, 209862798 |
| Protein | NP_009298, 6382062 |
| Product | tyrosine-protein kinase ABL2 isoform b |
| RefSeq Status | REVIEWED |
| mRNA | NM_005158, 269847767 |
| Protein | NP_005149, 269847768 |
| Product | tyrosine-protein kinase ABL2 isoform c |
| RefSeq Status | REVIEWED |
| mRNA | NM_001136000, 269847772 |
| Protein | NP_001129472, 209862772 |
| Product | tyrosine-protein kinase ABL2 isoform d |
| RefSeq Status | REVIEWED |
| mRNA | NM_001168236, 269847775 |
| Protein | NP_001161708, 269847776 |
| Product | tyrosine-protein kinase ABL2 isoform f |
| RefSeq Status | REVIEWED |
| mRNA | NM_001168237, 269847780 |
| Protein | NP_001161709, 269847781 |
| Product | tyrosine-protein kinase ABL2 isoform g |
| RefSeq Status | REVIEWED |
| mRNA | NM_001168238, 269847785 |
| Protein | NP_001161710, 269847786 |
| Product | tyrosine-protein kinase ABL2 isoform h |
| RefSeq Status | REVIEWED |
| mRNA | NM_001168239, 269847792 |
| Protein | NP_001161711, 269847793 |
| Product | tyrosine-protein kinase ABL2 isoform i |
| RefSeq Status | REVIEWED |
| hsa05416 | Viral myocarditis |
| hsa04012 | ErbB signaling pathway |
Reactome
| REACT_18266 | Axon guidance |
| REACT_19230 | Role of Abl in Robo-Slit signaling |
| REACT_19351 | Signaling by Robo receptor |
| Homo sapiens (human) | ABL2 | NP_001161709.1 |
| Pan troglodytes (chimpanzee) | ABL2 | XP_001156169.1 |
| Canis lupus familiaris (dog) | ABL2 | XP_860695.1 |
| Bos taurus (cattle) | ABL2 | XP_001253285.1 |
| Mus musculus (house mouse) | Abl2 | NP_033725.2 |
| Rattus norvegicus (Norway rat) | Abl2 | XP_222768.4 |
| Gallus gallus (chicken) | ABL2 | XP_422269.2 |
| Danio rerio (zebrafish) | abl2 | NP_001116177.1 |
| ID | Name | Evidence |
| GO:0006464 | protein modification process | TAS |
| GO:0007155 | cell adhesion | IEA |
| GO:0007165 | signal transduction | TAS |
| GO:0007411 | axon guidance | TAS |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IDA |
| GO:0051353 | positive regulation of oxidoreductase activity | IDA |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
| GO:0005829 | cytosol | EXP |
| GO:0005856 | cytoskeleton | IEA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0000287 | magnesium ion binding | IDA |
| GO:0004672 | protein kinase activity | TAS |
| GO:0004713 | protein tyrosine kinase activity | IDA |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0030145 | manganese ion binding | IDA |
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