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ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28550 NM_001168237 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant g, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu28556 NM_001168238 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant h, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu28564 NM_001168239 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant i, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu28569 NM_007314 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant b, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu28576 NM_001168236 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant f, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu28588 NM_001136001 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant e, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu28589 NM_005158 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant c, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu28593 NM_001136000 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant d, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu34313 XM_005245088 PREDICTED: Homo sapiens c-abl oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu28550C NM_001168237 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant g, mRNA. Customized vector On-demand 25 $1699.00
OHu28556C NM_001168238 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant h, mRNA. Customized vector On-demand 25 $1699.00
OHu28564C NM_001168239 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant i, mRNA. Customized vector On-demand 25 $1699.00
OHu28569C NM_007314 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant b, mRNA. Customized vector On-demand 25 $1699.00
OHu28576C NM_001168236 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant f, mRNA. Customized vector On-demand 25 $1699.00
OHu28588C NM_001136001 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant e, mRNA. Customized vector On-demand 7-9 $269.00
OHu28589C NM_005158 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant c, mRNA. Customized vector On-demand 25 $1699.00
OHu28593C NM_001136000 Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant d, mRNA. Customized vector On-demand 25 $1699.00
OHu34313C XM_005245088 PREDICTED: Homo sapiens c-abl oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant X1, mRNA. Customized vector On-demand 25 $1699.00

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Gene Symbol ABL2
Entrez Gene ID 27
Full Name ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms ABLL, ARG
General protein information
Preferred Names
Abelson tyrosine-protein kinase 2
Names
Abelson tyrosine-protein kinase 2
tyrosine-protein kinase ARG
abelson-related gene protein
v-abl Abelson murine leukemia viral oncogene homolog 2
NP_001129472.1
NP_001129473.1
NP_001161708.1
NP_001161709.1
NP_001161710.1
NP_001161711.1
NP_005149.4
NP_009298.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q25.2

Summary This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009].
Disorder

MIM: 164690

Leukemia, acute myeloid, with eosinophilia (1)

mRNA Protein Product Sequence Price Select
NM_001136000, 269847772 NP_001129472, 209862772 Abelson tyrosine-protein kinase 2 isoform d ORF Sequence $1500.00
NM_001136001, 209862777 NP_001129473, 209862778 Abelson tyrosine-protein kinase 2 isoform e ORF Sequence $550.00
NM_001168236, 269847775 NP_001161708, 269847776 Abelson tyrosine-protein kinase 2 isoform f ORF Sequence $1500.00
NM_001168237, 269847780 NP_001161709, 269847781 Abelson tyrosine-protein kinase 2 isoform g ORF Sequence $1500.00
NM_001168238, 269847785 NP_001161710, 269847786 Abelson tyrosine-protein kinase 2 isoform h ORF Sequence $1500.00
NM_001168239, 269847792 NP_001161711, 269847793 Abelson tyrosine-protein kinase 2 isoform i ORF Sequence $1500.00
NM_005158, 269847767 NP_005149, 269847768 Abelson tyrosine-protein kinase 2 isoform c ORF Sequence $1500.00
NM_007314, 209862798 NP_009298, 6382062 Abelson tyrosine-protein kinase 2 isoform b ORF Sequence $1500.00
XM_005245088, 530364561 XP_005245145, 530364562 Abelson tyrosine-protein kinase 2 isoform X1 ORF Sequence $1500.00
KEGG
hsa04012ErbB signaling pathway
hsa05416Viral myocarditis
hsa04014Ras signaling pathway
Reactome
REACT_18266Axon guidance
REACT_19351Signaling by Robo receptor
REACT_19230Role of Abl in Robo-Slit signaling
REACT_111045Developmental Biology
Homo sapiens (human)ABL2NP_009298.1
Pan troglodytes (chimpanzee)ABL2XP_003308662.1
Macaca mulatta (Rhesus monkey)ABL2XP_001115453.2
Canis lupus familiaris (dog)ABL2XP_537174.2
Bos taurus (cattle)ABL2NP_001137327.1
Mus musculus (house mouse)Abl2NP_033725.2
Rattus norvegicus (Norway rat)Abl2NP_001100656.1
Gallus gallus (chicken)ABL2XP_422269.4
Danio rerio (zebrafish)abl2NP_001116177.1
Xenopus (Silurana) tropicalis (western clawed frog)abl2XP_002937405.1
Process
IDNameEvidence
GO:0006464cellular protein modification processTAS
GO:0007155cell adhesionIEA
GO:0007165signal transductionTAS
GO:0007411axon guidanceTAS
GO:0010506regulation of autophagyTAS
GO:0010976positive regulation of neuron projection developmentIMP
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0030100regulation of endocytosisTAS
GO:0030155regulation of cell adhesionTAS
GO:0051017actin filament bundle assemblyIEA
GO:0051353positive regulation of oxidoreductase activityIDA
GO:0071300cellular response to retinoic acidIMP
GO:2000145regulation of cell motilityTAS
GO:2000249regulation of actin cytoskeleton reorganizationTAS
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:0015629actin cytoskeletonTAS
Function
IDNameEvidence
GO:0000287magnesium ion bindingIDA
GO:0003785actin monomer bindingTAS
GO:0004672protein kinase activityTAS
GO:0004713protein tyrosine kinase activityIDA
GO:0004715non-membrane spanning protein tyrosine kinase activityTAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0030145manganese ion bindingIDA
GO:0051015actin filament bindingTAS
GeneCards ABL2
UniProt P42684
Vega OTTHUMG00000035199
MIM 164690
Ensembl ENSG00000143322
HGNC 77
HPRD 01259

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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