DISC1 disrupted in schizophrenia 1 [Homo sapiens (human)]
| Gene Symbol | DISC1 |
| Entrez Gene ID | 27185 |
| Full Name | disrupted in schizophrenia 1 |
| Synonyms | C1orf136, FLJ13381, FLJ21640, FLJ25311, FLJ41105, KIAA0457, SCZD9 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1q42.1 |
| Summary | This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]. |
| Disorder | MIM: 605210 {Schizophrenia, susceptibility to}, 604906 (3); {Schizoaffective |
| mRNA | NM_001164550, 257153292 |
| Protein | NP_001158022, 257153293 |
| Product | disrupted in schizophrenia 1 protein isoform m |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164551, 257153294 |
| Protein | NP_001158023, 257153295 |
| Product | disrupted in schizophrenia 1 protein isoform n |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164552, 257153296 |
| Protein | NP_001158024, 257153297 |
| Product | disrupted in schizophrenia 1 protein isoform o |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164553, 257153298 |
| Protein | NP_001158025, 257153299 |
| Product | disrupted in schizophrenia 1 protein isoform p |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164554, 257153300 |
| Protein | NP_001158026, 257153301 |
| Product | disrupted in schizophrenia 1 protein isoform q |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164555, 257153302 |
| Protein | NP_001158027, 257153303 |
| Product | disrupted in schizophrenia 1 protein isoform r |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164556, 257153304 |
| Protein | NP_001158028, 257153305 |
| Product | disrupted in schizophrenia 1 protein isoform t |
| RefSeq Status | REVIEWED |
| mRNA | NM_018662, 61742822 |
| Protein | NP_061132, 61742823 |
| Product | disrupted in schizophrenia 1 protein isoform L |
| RefSeq Status | REVIEWED |
| mRNA | NM_001012957, 61742824 |
| Protein | NP_001012975, 61742825 |
| Product | disrupted in schizophrenia 1 protein isoform Lv |
| RefSeq Status | REVIEWED |
| mRNA | NM_001012958, 61742826 |
| Protein | NP_001012976, 61742827 |
| Product | disrupted in schizophrenia 1 protein isoform Es |
| RefSeq Status | REVIEWED |
| mRNA | NM_001012959, 61742828 |
| Protein | NP_001012977, 61742829 |
| Product | disrupted in schizophrenia 1 protein isoform S |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164537, 257153458 |
| Protein | NP_001158009, 257153459 |
| Product | disrupted in schizophrenia 1 protein isoform a |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164538, 257153460 |
| Protein | NP_001158010, 257153461 |
| Product | disrupted in schizophrenia 1 protein isoform b |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164540, 257153464 |
| Protein | NP_001158012, 257153465 |
| Product | disrupted in schizophrenia 1 protein isoform d |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164542, 257153468 |
| Protein | NP_001158014, 257153469 |
| Product | disrupted in schizophrenia 1 protein isoform f |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164544, 257153471 |
| Protein | NP_001158016, 257153472 |
| Product | disrupted in schizophrenia 1 protein isoform g |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164548, 257153479 |
| Protein | NP_001158020, 257153480 |
| Product | disrupted in schizophrenia 1 protein isoform k |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164549, 257153481 |
| Protein | NP_001158021, 257153482 |
| Product | disrupted in schizophrenia 1 protein isoform l |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164539, 257153462 |
| Protein | NP_001158011, 257153463 |
| Product | disrupted in schizophrenia 1 protein isoform c |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164541, 257153466 |
| Protein | NP_001158013, 257153467 |
| Product | disrupted in schizophrenia 1 protein isoform e |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164545, 257153473 |
| Protein | NP_001158017, 257153474 |
| Product | disrupted in schizophrenia 1 protein isoform h |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164546, 257153475 |
| Protein | NP_001158018, 257153476 |
| Product | disrupted in schizophrenia 1 protein isoform i |
| RefSeq Status | REVIEWED |
| mRNA | NM_001164547, 257153477 |
| Protein | NP_001158019, 257153478 |
| Product | disrupted in schizophrenia 1 protein isoform j |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | DISC1 | NP_001012975.1 |
| Pan troglodytes (chimpanzee) | DISC1 | XP_001151459.1 |
| Canis lupus familiaris (dog) | DISC1 | XP_546088.2 |
| Bos taurus (cattle) | DISC1 | XP_001252165.2 |
| Mus musculus (house mouse) | Disc1 | NP_777279.2 |
| Rattus norvegicus (Norway rat) | Disc1 | NP_783186.2 |
| ID | Name | Evidence |
| GO:0000226 | microtubule cytoskeleton organization | IMP |
| GO:0001764 | neuron migration | IMP |
| GO:0002052 | positive regulation of neuroblast proliferation | IGI |
| GO:0007275 | multicellular organismal development | IEA |
| GO:0007399 | nervous system development | IEA |
| GO:0030177 | positive regulation of Wnt receptor signaling pathway | IGI |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
| GO:0005813 | centrosome | IDA |
| GO:0005856 | cytoskeleton | IEA |
| GO:0005874 | microtubule | IEA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |