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GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_006496 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 (GNAI3), mRNA. ORF Sequence $308.85
Peptide Services
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Gene Symbol GNAI3
Entrez Gene ID 2773
Full Name guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Synonyms 87U6, FLJ26559
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p13

Summary Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012].
Disorder

MIM: 139370

mRNA Protein Product Sequence Price Select
NM_006496, 391224482 NP_006487, 5729850 guanine nucleotide-binding protein G(k) subunit alpha Full Length $1661.80
ORF Sequence $308.85
KEGG
hsa04724Glutamatergic synapse
hsa04916Melanogenesis
hsa05145Toxoplasmosis
hsa04713Circadian entrainment
hsa04728Dopaminergic synapse
hsa04540Gap junction
hsa05032Morphine addiction
hsa04360Axon guidance
hsa04062Chemokine signaling pathway
hsa04727GABAergic synapse
hsa05133Pertussis
hsa04723Retrograde endocannabinoid signaling
hsa04726Serotonergic synapse
hsa04670Leukocyte transendothelial migration
hsa04914Progesterone-mediated oocyte maturation
hsa04971Gastric acid secretion
hsa05142Chagas disease (American trypanosomiasis)
hsa04730Long-term depression
hsa05030Cocaine addiction
hsa04725Cholinergic synapse
hsa05034Alcoholism
hsa04530Tight junction
WikiPathways
WP26Signal Transduction of S1P Receptor
WP536Calcium Regulation in the Cardiac Cell
WP35G Protein Signaling Pathways
WP2032TSH signaling pathway
Pathway Interaction Database
s1p_s1p2_pathwayS1P2 pathway
cxcr3pathwayCXCR3-mediated signaling events
s1p_meta_pathwaySphingosine 1-phosphate (S1P) pathway
s1p_s1p4_pathwayS1P4 pathway
s1p_s1p3_pathwayS1P3 pathway
erbb1_receptor_proximal_pathwayEGF receptor (ErbB1) signaling pathway
lysophospholipid_pathwayLPA receptor mediated events
s1p_s1p1_pathwayS1P1 pathway
s1p_s1p5_pathwayS1P5 pathway
Reactome
REACT_15333Adenylate cyclase inhibitory pathway
REACT_13477Transmission across Chemical Synapses
REACT_19333G alpha (z) signalling events
REACT_15295Opioid Signalling
REACT_25199GABA receptor activation
REACT_19327G alpha (s) signalling events
REACT_19231G alpha (i) signalling events
REACT_13685Neuronal System
REACT_15526G-protein mediated events
REACT_15426PLC beta mediated events
REACT_111102Signal Transduction
REACT_798Platelet activation, signaling and aggregation
REACT_14797Signaling by GPCR
REACT_25330Activation of GABAB receptors
REACT_20524Signal amplification
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_25031GABA B receptor activation
REACT_20653ADP signalling through P2Y purinoceptor 12
REACT_15457G-protein activation
REACT_19184GPCR downstream signaling
REACT_25282Inhibition of adenylate cyclase pathway
REACT_604Hemostasis
Homo sapiens (human)GNAI3NP_006487.1
Pan troglodytes (chimpanzee)GNAI3XP_513624.1
Macaca mulatta (Rhesus monkey)GNAI3XP_001091470.1
Canis lupus familiaris (dog)GNAI3XP_854614.3
Bos taurus (cattle)GNAI3NP_001029849.1
Mus musculus (house mouse)Gnai3NP_034436.1
Rattus norvegicus (Norway rat)Gnai3NP_037238.1
Gallus gallus (chicken)GNAI3NP_989580.1
Danio rerio (zebrafish)gnai3NP_001104720.1
GeneCards GNAI3
PDB 4G5R, 4G5O, 4G5S, 2IHB, 2V4Z, 2ODE
UniProt P08754, Q5TZX1
MIM 139370
Ensembl ENSG00000065135
HGNC 4387
HPRD 00765

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
guanine nucleotide-binding protein G(k) subunit alpha
Names
guanine nucleotide-binding protein G(k) subunit alpha
g(i) alpha-3

Interactant

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