GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [Homo sapiens (human)]

Gene Symbol	GNAI3
Entrez Gene ID	2773
Full Name	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Synonyms	87U6, FLJ26559
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:1 Map Location:1p13
Summary
Disorder	MIM: 139370

mRNA	NM_006496, 169646784
Protein	NP_006487, 5729850
Product	guanine nucleotide-binding protein G(k) subunit alpha
RefSeq Status	VALIDATED

KEGG

hsa04914	Progesterone-mediated oocyte maturation
hsa05142	Chagas disease (American trypanosomiasis)
hsa04971	Gastric acid secretion
hsa04730	Long-term depression
hsa04062	Chemokine signaling pathway
hsa04670	Leukocyte transendothelial migration
hsa04530	Tight junction
hsa05145	Toxoplasmosis
hsa04916	Melanogenesis
hsa04540	Gap junction
hsa04360	Axon guidance

Pathway Interaction Database

cxcr3pathway	CXCR3-mediated signaling events
s1p_s1p3_pathway	S1P3 pathway
erbb1_receptor_proximal_pathway	EGF receptor (ErbB1) signaling pathway
lysophospholipid_pathway	LPA receptor mediated events
s1p_s1p1_pathway	S1P1 pathway
s1p_s1p5_pathway	S1P5 pathway
s1p_s1p4_pathway	S1P4 pathway
s1p_meta_pathway	Sphingosine 1-phosphate (S1P) pathway
s1p_s1p2_pathway	S1P2 pathway

WikiPathways

WP26	Signal Transduction of S1P Receptor
WP35	G Protein Signaling Pathways
WP536	Calcium Regulation in the Cardiac Cell

Reactome

REACT_13477	Transmission across Chemical Synapses
REACT_20	Formation of Platelet plug
REACT_798	Platelet Activation
REACT_19231	G alpha (i) signalling events
REACT_13685	Synaptic Transmission
REACT_25199	GABA receptor activation
REACT_15426	PLC beta mediated events
REACT_20524	Signal amplification
REACT_25330	Activation of GABAB receptors
REACT_15370	Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_14797	Signaling by GPCR
REACT_25031	GABA B receptor activation
REACT_622	Platelet activation triggers
REACT_20653	ADP signalling through P2Y purinoceptor 12
REACT_15457	G-protein activation
REACT_19184	GPCR downstream signaling
REACT_25282	Inhibition of adenylate cyclase pathway
REACT_604	Hemostasis
REACT_15333	Adenylate cyclase inhibitory pathway
REACT_19327	G alpha (s) signalling events
REACT_15295	Opioid Signalling
REACT_19333	G alpha (z) signalling events
REACT_15526	G-protein mediated events

Homo sapiens (human)	GNAI3	NP_006487.1
Pan troglodytes (chimpanzee)	GNAI3	XP_513624.1
Canis lupus familiaris (dog)	GNAI3	XP_854614.1
Bos taurus (cattle)	GNAI3	NP_001029849.1
Mus musculus (house mouse)	Gnai3	NP_034436.1
Rattus norvegicus (Norway rat)	Gnai3	NP_037238.1
Gallus gallus (chicken)	GNAI3	NP_989580.1
Danio rerio (zebrafish)	gnai3	NP_001104720.1

Process

ID	Name	Evidence
GO:0006184	GTP catabolic process	ISS
GO:0006184	GTP catabolic process	TAS
GO:0006810	transport	NAS
GO:0006906	vesicle fusion	IEA
GO:0007165	signal transduction	ISS
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA
GO:0007193	inhibition of adenylate cyclase activity by G-protein signaling pathway	EXP
GO:0007194	negative regulation of adenylate cyclase activity	TAS
GO:0007268	synaptic transmission	TAS
GO:0007596	blood coagulation	TAS
GO:0030168	platelet activation	TAS
GO:0050805	negative regulation of synaptic transmission	IEA
GO:0051301	cell division	IDA

Component

ID	Name	Evidence
GO:0005624	membrane fraction	IEA
GO:0005737	cytoplasm	IDA
GO:0005813	centrosome	IDA
GO:0005834	heterotrimeric G-protein complex	ISS
GO:0005886	plasma membrane	EXP
GO:0005886	plasma membrane	IDA
GO:0005886	plasma membrane	TAS
GO:0030496	midbody	IDA
GO:0031234	extrinsic to internal side of plasma membrane	ISS
GO:0042588	zymogen granule	IEA
GO:0045121	membrane raft	IEA

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0003924	GTPase activity	ISS
GO:0003924	GTPase activity	TAS
GO:0004871	signal transducer activity	ISS
GO:0005525	GTP binding	EXP
GO:0019001	guanyl nucleotide binding	IEA
GO:0031683	G-protein beta/gamma-subunit complex binding	ISS
GO:0031821	metabotropic serotonin receptor binding	ISS

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

RefSeq Accession	Definition	Sequence	Price	Select
NM_006496	Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 (GNAI3), mRNA.	Full Length	$1655.50
NM_006496		ORF Sequence	$308.85