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GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19778 NM_006496 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 (GNAI3), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu19778C NM_006496 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 (GNAI3), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol GNAI3
Entrez Gene ID 2773
Full Name guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Synonyms 87U6, ARCND1
General protein information
Preferred Names
guanine nucleotide-binding protein G(k) subunit alpha
Names
guanine nucleotide-binding protein G(k) subunit alpha
g(i) alpha-3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p13

Summary Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012].
Disorder

MIM: 139370

mRNA Protein Product Sequence Price Select
NM_006496, 391224482 NP_006487, 5729850 guanine nucleotide-binding protein G(k) subunit alpha ORF Sequence $269.00
KEGG
hsa04360Axon guidance
hsa04530Tight junction
hsa04730Long-term depression
hsa04670Leukocyte transendothelial migration
hsa04916Melanogenesis
hsa05012Parkinson's disease
hsa04540Gap junction
hsa04062Chemokine signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa04971Gastric acid secretion
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa05133Pertussis
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04726Serotonergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa04713Circadian entrainment
hsa05030Cocaine addiction
hsa04915Estrogen signaling pathway
hsa05034Alcoholism
hsa05032Morphine addiction
hsa04261Adrenergic signaling in cardiomyocytes
hsa04921Oxytocin signaling pathway
hsa04611Platelet activation
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP35G Protein Signaling Pathways
WP26Signal Transduction of S1P Receptor
WP536Calcium Regulation in the Cardiac Cell
WP2032TSH signaling pathway
Pathway Interaction Database
lysophospholipid_pathwayLPA receptor mediated events
s1p_meta_pathwaySphingosine 1-phosphate (S1P) pathway
s1p_s1p1_pathwayS1P1 pathway
erbb1_receptor_proximal_pathwayEGF receptor (ErbB1) signaling pathway
s1p_s1p5_pathwayS1P5 pathway
cxcr3pathwayCXCR3-mediated signaling events
s1p_s1p3_pathwayS1P3 pathway
s1p_s1p2_pathwayS1P2 pathway
s1p_s1p4_pathwayS1P4 pathway
Reactome
REACT_19184GPCR downstream signaling
REACT_19327G alpha (s) signalling events
REACT_19231G alpha (i) signalling events
REACT_19333G alpha (z) signalling events
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_14797Signaling by GPCR
REACT_15295Opioid Signalling
REACT_15526G-protein mediated events
REACT_15426PLC beta mediated events
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_15457G-protein activation
REACT_13477Transmission across Chemical Synapses
REACT_15333Adenylate cyclase inhibitory pathway
REACT_13685Neuronal System
REACT_20524Signal amplification
REACT_20653ADP signalling through P2Y purinoceptor 12
REACT_25031GABA B receptor activation
REACT_25330Activation of GABAB receptors
REACT_25199GABA receptor activation
REACT_25282Inhibition of adenylate cyclase pathway
REACT_111102Signal Transduction
Homo sapiens (human)GNAI3NP_006487.1
Pan troglodytes (chimpanzee)GNAI3XP_513624.1
Macaca mulatta (Rhesus monkey)GNAI3XP_001091470.1
Canis lupus familiaris (dog)GNAI3XP_854614.3
Bos taurus (cattle)GNAI3NP_001029849.1
Mus musculus (house mouse)Gnai3NP_034436.1
Rattus norvegicus (Norway rat)Gnai3NP_037238.1
Gallus gallus (chicken)GNAI3NP_989580.1
Danio rerio (zebrafish)gnai3NP_001104720.1
Xenopus (Silurana) tropicalis (western clawed frog)gnai3NP_001011471.1
Process
IDNameEvidence
GO:0006184GTP catabolic processIEA
GO:0006810transportNAS
GO:0006906vesicle fusionIEA
GO:0007049cell cycleIEA
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIBA
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayTAS
GO:0007194negative regulation of adenylate cyclase activityTAS
GO:0007268synaptic transmissionTAS
GO:0007596blood coagulationTAS
GO:0030168platelet activationTAS
GO:0051301cell divisionIDA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005765lysosomal membraneIDA
GO:0005794Golgi apparatusIEA
GO:0005813centrosomeIDA
GO:0005834heterotrimeric G-protein complexIBA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0016020membraneIDA
GO:0030496midbodyIDA
GO:0042588zymogen granuleIEA
GO:0045121membrane raftIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0003924GTPase activityIBA
GO:0004871signal transducer activityIBA
GO:0005525GTP bindingIEA
GO:0019904protein domain specific bindingIEA
GO:0031683G-protein beta/gamma-subunit complex bindingIBA
GO:0031821G-protein coupled serotonin receptor bindingIBA
GO:0032794GTPase activating protein bindingIEA
GO:0046872metal ion bindingIEA
GeneCards GNAI3
PDB 4G5R, 4G5O, 4G5S, 2IHB, 2V4Z, 2ODE
UniProt P08754
MIM 139370
HGNC 4387
HPRD 00765

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