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GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_020988 Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (GNAO1), transcript variant 1, mRNA. Full Length $1166.20
ORF Sequence $308.85
NM_138736 Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (GNAO1), transcript variant 2, mRNA. Full Length $2803.05
ORF Sequence $308.85


Gene Symbol GNAO1
Entrez Gene ID 2775
Full Name guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Synonyms DKFZp686O0962, G-ALPHA-o, GNAO
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16q13
Summary
Disorder

MIM: 139311
mRNA NM_020988, 162461666
Protein NP_066268, 10567816
Product guanine nucleotide-binding protein G(o) subunit alpha isoform a
RefSeq Status VALIDATED
mRNA NM_138736, 162461737
Protein NP_620073, 162461738
Product guanine nucleotide-binding protein G(o) subunit alpha isoform b
RefSeq Status VALIDATED
KEGG
hsa04916Melanogenesis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa04730Long-term depression
WikiPathways
WP536Calcium Regulation in the Cardiac Cell
WP35G Protein Signaling Pathways
Pathway Interaction Database
s1p_s1p5_pathwayS1P5 pathway
s1p_s1p4_pathwayS1P4 pathway
s1p_s1p2_pathwayS1P2 pathway
s1p_meta_pathwaySphingosine 1-phosphate (S1P) pathway
s1p_s1p3_pathwayS1P3 pathway
lysophospholipid_pathwayLPA receptor mediated events
s1p_s1p1_pathwayS1P1 pathway
Reactome
REACT_15457G-protein activation
REACT_15426PLC beta mediated events
REACT_15380Diabetes pathways
REACT_18325Regulation of Insulin Secretion
REACT_15526G-protein mediated events
REACT_15295Opioid Signalling
REACT_18339Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
REACT_1505Integration of energy metabolism
Homo sapiens (human)GNAO1NP_066268.1
Pan troglodytes (chimpanzee)GNAO1XP_510976.2
Canis lupus familiaris (dog)GNAO1XP_863244.1
Bos taurus (cattle)GNAO1NP_776750.1
Mus musculus (house mouse)Gnao1NP_034438.1
Rattus norvegicus (Norway rat)Gnao1NP_059023.1
Gallus gallus (chicken)GNAO1XP_001232687.1
Danio rerio (zebrafish)gnao1aNP_957081.1
Drosophila melanogaster (fruit fly)G-oalpha47ANP_788305.1
Caenorhabditis elegansgoa-1NP_492108.1
Process
IDNameEvidence
GO:0006184GTP catabolic processISS
GO:0006184GTP catabolic processTAS
GO:0006936muscle contractionTAS
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerISS
GO:0007212dopamine receptor signaling pathwayISS
GO:0007568agingIEA
GO:0007626locomotory behaviorIEA
GO:0008016regulation of heart contractionIEA
GO:0009987cellular processIEA
GO:0010243response to organic nitrogenIEA
GO:0014070response to organic cyclic compoundIEA
GO:0030900forebrain developmentIEA
GO:0031175neuron projection developmentIEA
GO:0034097response to cytokine stimulusIEA
GO:0042493response to drugIEA
GO:0042542response to hydrogen peroxideIEA
GO:0043278response to morphineIEA
GO:0043547positive regulation of GTPase activityIEA
GO:0051926negative regulation of calcium ion transportIEA
Component
IDNameEvidence
GO:0005622intracellularIEA
GO:0005834heterotrimeric G-protein complexISS
GO:0005886plasma membraneEXP
GO:0005886plasma membraneTAS
GO:0019717synaptosomeIEA
GO:0031234extrinsic to internal side of plasma membraneISS
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003924GTPase activityISS
GO:0003924GTPase activityTAS
GO:0004871signal transducer activityISS
GO:0005525GTP bindingEXP
GO:0019001guanyl nucleotide bindingIEA
GO:0031683G-protein beta/gamma-subunit complex bindingISS
GO:0031821metabotropic serotonin receptor bindingISS
GO:0031852mu-type opioid receptor bindingIEA
GeneCards GNAO1
UniProt Q8N6I9, B3KP89, P09471, Q6AWC5
MIM 139311
Ensembl ENSG00000087258
HGNC 4389
HPRD 00757

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