Sequence in raw or FASTA format:
GOLGA4 golgin A4 [
Homo sapiens (human)]
Gene Symbol GOLGA4
Entrez Gene ID
Full Name golgin A4
Synonyms GCP2, GOLG, MU-RMS-40.18, p230
General protein information
Golgin subfamily A member 4
Golgin subfamily A member 4
256 kDa golgin
golgi autoantigen, golgin subfamily a, 4
Gene Type protein-coding
Homo sapiens (human)
Chromosome:3 Map Location:3p22-p21.3
Summary The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010].
ID Name Evidence
GO:0000042 protein targeting to Golgi IEA
GO:0016192 vesicle-mediated transport TAS
GO:0043001 Golgi to plasma membrane protein transport IDA
Related articles in PubMed Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983. Analysis of the human immunodeficiency virus type 1 M group Vpu domains involved in antagonizing tetherin. Petit SJ, et al. J Gen Virol, 2011 Dec. PMID 21900423. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048. Identification of DeltaNp63alpha protein interactions by mass spectrometry. Amoresano A, et al. J Proteome Res, 2010 Apr 5. PMID 20085233. See all (30) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
CD99 also binds p230/golgin-245, a coiled-coil protein that recycles between the cytosol and buds/vesicles of the TGN and which plays a fundamental role in trafficking transport vesicles.
Title: Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction.
The protein CrpF46 has an apparent molecular mass of ~60 kDa, is highly homologous to a 527 amino acid sequence of the C-terminal portion of the protein Golgin-245, and appears to be a splice variant of Golgin-245.
Title: Identification of a novel centrosomal protein CrpF46 involved in cell cycle progression and mitosis.
golgin-245 is a key regulator of TNF secretion; LPS activation of macrophages results in increased Golgi carriers for export, up-regulating the transport pathway for TNF export.
Title: A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo.
The ability of the four mammalian GRIP domain proteins, p230, golgin-97, GCC88, and GCC185 to interact is reported.
Title: The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.
tGolgin-1 functions in Golgi positioning indirectly, probably by regulating retrograde movement of cargo required for recruitment or activation of dynein-dynactin complexes on newly formed Golgi elements.
Title: tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre.
crystal structure of Arl1-GTP in complex with the GRIP domain of golgin-245 shows that Arl1-GTP interacts with the GRIP domain predominantly in a hydrophobic manner, with the switch II region conferring the main recognition surface
Title: Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1.
P230, through its interaction with MACF1, provides the molecular link for transport of GPI-anchored proteins along the microtubule and actin cytoskeleton from the TGN to the cell periphery.
Title: Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery.
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