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COL1A1 collagen, type I, alpha 1 [Bos taurus (cattle)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001034039 Bos taurus collagen, type I, alpha 1 (COL1A1), mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005220486 PREDICTED: Bos taurus collagen, type I, alpha 1 (COL1A1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

*Business Day

Related Services

Gene Symbol COL1A1
Entrez Gene ID 282187
Full Name collagen, type I, alpha 1
Synonyms
General protein information
Preferred Names
collagen alpha-1(I) chain
Names
collagen alpha-1(I) chain
alpha-1 type I collagen
Gene Type protein-coding
Organism Bos taurus (cattle)
Genome

19

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_001034039, 402744897 NP_001029211, 77404252 collagen alpha-1(I) chain precursor ORF Sequence $1500.00
XM_005220486, 528995542 XP_005220543, 528995543 collagen alpha-1(I) chain isoform X1 ORF Sequence $1500.00
KEGG
bta04510Focal adhesion
bta04512ECM-receptor interaction
bta05146Amoebiasis
bta04974Protein digestion and absorption
bta04151PI3K-Akt signaling pathway
bta04611Platelet activation
WikiPathways
WP1040Inflammatory Response Pathway
WP1074Osteoblast
Reactome
5493857Extracellular matrix organization
5494646Assembly of collagen fibrils and other multimeric structures
5494647Collagen formation
5494674Collagen biosynthesis and modifying enzymes
Homo sapiens (human)COL1A1NP_000079.2
Pan troglodytes (chimpanzee)COL1A1XP_001169409.1
Macaca mulatta (Rhesus monkey)COL1A1XP_001096194.2
Canis lupus familiaris (dog)COL1A1NP_001003090.1
Bos taurus (cattle)COL1A1NP_001029211.1
Mus musculus (house mouse)Col1a1NP_031768.2
Rattus norvegicus (Norway rat)Col1a1NP_445756.1
Danio rerio (zebrafish)col1a1aNP_954684.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC496414NP_001011005.1
Process
IDNameEvidence
GO:0001568blood vessel developmentIEA
GO:0001649osteoblast differentiationIEA
GO:0001957intramembranous ossificationIEA
GO:0001958endochondral ossificationIEA
GO:0007601visual perceptionIEA
GO:0007605sensory perception of soundIEA
GO:0010718positive regulation of epithelial to mesenchymal transitionIEA
GO:0010812negative regulation of cell-substrate adhesionIEA
GO:0015031protein transportIEA
GO:0030199collagen fibril organizationIEA
GO:0030335positive regulation of cell migrationIEA
GO:0032964collagen biosynthetic processIEA
GO:0034504protein localization to nucleusIEA
GO:0034505tooth mineralizationIEA
GO:0043589skin morphogenesisIEA
GO:0045893positive regulation of transcription, DNA-templatedIEA
GO:0048706embryonic skeletal system developmentIEA
GO:0060325face morphogenesisIEA
GO:0060346bone trabecula formationIEA
GO:0060351cartilage development involved in endochondral bone morphogenesisIEA
GO:0070208protein heterotrimerizationIEA
GO:0071230cellular response to amino acid stimulusIEA
GO:0071260cellular response to mechanical stimulusIEA
GO:0090263positive regulation of canonical Wnt signaling pathwayIEA
Component
IDNameEvidence
GO:0005584collagen type I trimerIEA
GO:0005615extracellular spaceIEA
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0005201extracellular matrix structural constituentIEA
GO:0042802identical protein bindingIEA
GO:0046872metal ion bindingIEA
GO:0048407platelet-derived growth factor bindingIEA
GeneCards COL1A1
UniProt P02453
BGD BT10494
Ensembl ENSBTAG00000013103

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the COL1A1 gene?

The COL1A1 gene provides instructions for making part of a large molecule called type I collagen. Collagens are a family of proteins that strengthen and support many tissues in the body, including cartilage, bone, tendon, skin, and the white part of the eye (the sclera). Type I collagen is the most abundant form of collagen in the human body.

The COL1A1 gene produces a component of type I collagen called the pro-α1(I) chain. Collagens begin as procollagen molecules, which must be processed by enzymes outside the cell to remove extra protein segments from their ends. Each rope-like procollagen molecule is made up of three chains: two pro-α1(I) chains, which are produced from the COL1A1 gene, and one pro-α2(I) chain, which is produced from the COL1A2 gene.

After procollagens are processed, the resulting mature collagen molecules arrange themselves into long, thin fibrils. Individual collagen molecules are cross-linked to one another within these fibrils. The formation of cross-links results in very strong type I collagen fibrils, which are found in the spaces around cells.

Interactant

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