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Sequence in raw or FASTA format:


Blast Method:


COL1A1 collagen, type I, alpha 1 [Bos taurus (cattle)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001034039 Bos taurus collagen, type I, alpha 1 (COL1A1), mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005220486 PREDICTED: Bos taurus collagen, type I, alpha 1 (COL1A1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Related Services

Gene Symbol COL1A1
Entrez Gene ID 282187
Full Name collagen, type I, alpha 1
General protein information
Preferred Names
collagen alpha-1(I) chain
collagen alpha-1(I) chain
alpha-1 type I collagen
Gene Type protein-coding
Organism Bos taurus (cattle)




mRNA Protein Product Sequence Price Select
NM_001034039, 402744897 NP_001029211, 77404252 collagen alpha-1(I) chain precursor ORF Sequence $1500.00
XM_005220486, 528995542 XP_005220543, 528995543 collagen alpha-1(I) chain isoform X1 ORF Sequence $1500.00
bta04510Focal adhesion
bta04512ECM-receptor interaction
bta04974Protein digestion and absorption
bta04151PI3K-Akt signaling pathway
bta04611Platelet activation
WP1040Inflammatory Response Pathway
5493857Extracellular matrix organization
5494646Assembly of collagen fibrils and other multimeric structures
5494647Collagen formation
5494674Collagen biosynthesis and modifying enzymes
Homo sapiens (human)COL1A1NP_000079.2
Pan troglodytes (chimpanzee)COL1A1XP_001169409.1
Macaca mulatta (Rhesus monkey)COL1A1XP_001096194.2
Canis lupus familiaris (dog)COL1A1NP_001003090.1
Bos taurus (cattle)COL1A1NP_001029211.1
Mus musculus (house mouse)Col1a1NP_031768.2
Rattus norvegicus (Norway rat)Col1a1NP_445756.1
Danio rerio (zebrafish)col1a1aNP_954684.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC496414NP_001011005.1
GO:0001568blood vessel developmentIEA
GO:0001649osteoblast differentiationIEA
GO:0001957intramembranous ossificationIEA
GO:0001958endochondral ossificationIEA
GO:0007601visual perceptionIEA
GO:0007605sensory perception of soundIEA
GO:0010718positive regulation of epithelial to mesenchymal transitionIEA
GO:0010812negative regulation of cell-substrate adhesionIEA
GO:0015031protein transportIEA
GO:0030199collagen fibril organizationIEA
GO:0030335positive regulation of cell migrationIEA
GO:0032964collagen biosynthetic processIEA
GO:0034504protein localization to nucleusIEA
GO:0034505tooth mineralizationIEA
GO:0043589skin morphogenesisIEA
GO:0045893positive regulation of transcription, DNA-templatedIEA
GO:0048706embryonic skeletal system developmentIEA
GO:0060325face morphogenesisIEA
GO:0060346bone trabecula formationIEA
GO:0060351cartilage development involved in endochondral bone morphogenesisIEA
GO:0070208protein heterotrimerizationIEA
GO:0071230cellular response to amino acid stimulusIEA
GO:0071260cellular response to mechanical stimulusIEA
GO:0090263positive regulation of canonical Wnt signaling pathwayIEA
GO:0005584collagen type I trimerIEA
GO:0005615extracellular spaceIEA
GO:0005201extracellular matrix structural constituentIEA
GO:0042802identical protein bindingIEA
GO:0046872metal ion bindingIEA
GO:0048407platelet-derived growth factor bindingIEA
GeneCards COL1A1
UniProt P02453
BGD BT10494
Ensembl ENSBTAG00000013103

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the COL1A1 gene?

The COL1A1 gene provides instructions for making part of a large molecule called type I collagen. Collagens are a family of proteins that strengthen and support many tissues in the body, including cartilage, bone, tendon, skin, and the white part of the eye (the sclera). Type I collagen is the most abundant form of collagen in the human body.

The COL1A1 gene produces a component of type I collagen called the pro-α1(I) chain. Collagens begin as procollagen molecules, which must be processed by enzymes outside the cell to remove extra protein segments from their ends. Each rope-like procollagen molecule is made up of three chains: two pro-α1(I) chains, which are produced from the COL1A1 gene, and one pro-α2(I) chain, which is produced from the COL1A2 gene.

After procollagens are processed, the resulting mature collagen molecules arrange themselves into long, thin fibrils. Individual collagen molecules are cross-linked to one another within these fibrils. The formation of cross-links results in very strong type I collagen fibrils, which are found in the spaces around cells.


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