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Sequence in raw or FASTA format:


Blast Method:


H19 H19, imprinted maternally expressed transcript (non-protein coding) [Homo sapiens (human)]

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Gene Symbol H19
Entrez Gene ID 283120
Full Name H19, imprinted maternally expressed transcript (non-protein coding)
Synonyms ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, PRO2605, WT2
General protein information
Gene Type ncRNA
Organism Homo sapiens (human)




MIM: 103280

Beckwith-Wiedemann syndrome, 130650 (3); Silver-Russell syndrome,

mRNA Protein Product Sequence Price Select
GeneCards H19
MIM 103280
Ensembl ENSG00000130600
HGNC 4713

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the H19 gene?

The H19 gene provides instructions for making a molecule called a noncoding RNA. (RNA is a chemical cousin of DNA.) Unlike many genes, the H19 gene does not contain instructions for making a protein. The function of the gene is unknown, but researchers believe that it may act as a tumor suppressor, keeping cells from growing and dividing too fast or in an uncontrolled way. This gene is highly active before birth and may play an important role in early development.

People inherit one copy of most genes from their mother and one copy from their father. Both copies are typically active, or "turned on," in cells. The H19 gene, however, is active only when it is inherited from a person's mother. This sort of parent-specific difference in gene activation is caused by a phenomenon called genomic imprinting.

H19 is part of a cluster of genes on the short (p) arm of chromosome 11 that undergo genomic imprinting. Another gene in this cluster, IGF2, is also involved in growth and development. A nearby region of DNA known as imprinting center 1 (ICR1) or the H19 differentially methylated region (H19 DMR) controls the parent-specific genomic imprinting of both the H19 and IGF2 genes.


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